Linkage is the close association of genes or other DNA sequences on the same chromosome. The closer two genes are to each other on the chromosome, the greater the probability that they will be inherited together.
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Linkage is referring to the close co-location of genes or of DNA variations to each other on the chromosomes. And these co-localizations are close enough that one can use genetic tools to find them being transmitted within families together. And the closer genes are to each other on a chromosome, the better chance you have to detect this linkage, because they are then more likely to be transmitted from grandparents, to parents, to children together, because there's less likely to be recombinations at meiosis between these genes. And so two genes that tend to be transmitted together we say are linked to each other.
Joan E. Bailey-Wilson, Ph.D.
Co-chief and Senior Investigator, Inherited Disease Research Branch; Head, Statistical Genetics Section
Dr. Bailey-Wilson develops new statistical methods and software and performs analyses that guide other genome scientists hunting for disease-associated genes. Trained in statistical genetics, she is interested in understanding the genetics of complex diseases and developing novel methodologies that can be used to disentangle the roles that genes and environment play in causing disease. Collaborating with other researchers, Dr. Bailey-Wilson studies a range of diseases, including lung cancer, prostate cancer, breast cancer, myopia and other eye diseases, and cleft lip and palate.