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Talking Glossary of Genetic Terms

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Elliott Margulies, Ph.D. defines Non-Coding DNA

Non-Coding DNA

Non-coding DNA sequences do not code for amino acids. Most non-coding DNA lies between genes on the chromosome and has no known function. Other non-coding DNA, called introns, is found within genes. Some non-coding DNA plays a role in the regulation of gene expression.

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Non-Coding DNA

Non-coding DNA sequences do not code for amino acids. Most non-coding DNA lies between genes on the chromosome and has no known function. Other non-coding DNA, called introns, is found within genes. Some non-coding DNA plays a role in the regulation of gene expression.

Narration Transcription

Non-coding DNA is just what it says; it's non-coding DNA. You can think of the genome as being split up into two parts. There's the stuff that codes for proteins. We call it coding DNA, and for a lack of a better term, the rest of genome is referred to as non-coding DNA. Some people will like to try and refer to this as junk DNA. But I would suggest otherwise, because this represents 98 percent of our genome sequence and it does all sorts of things, like regulate those genes to figure out where they should turn on, where they should turn off, how much we should turn on certain genes, how are we going to pack up the DNA into chromosomes, and so forth. And there are probably a whole host of functions that non-coding DNA does that we still don't know what it does yet.


Doctor Profile

Elliott Margulies, Ph.D.

Elliott Margulies, Ph.D.

Occupation
Investigator, Genome Technology Branch; Head, Genome Informatics Section

Biography
Dr. Margulies develops bioinformatical approaches to identifying and characterizing regions of the human genome that are evolutionarily conserved across multiple species. The conservation of these sequences over millions of years of evolution is strong evidence that they play important roles in biology, such as coding for genes or functioning as regulatory elements. He has played an important role in advancing the goals of the NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program. Dr. Margulies's group utilizes both high-performance computational analyses and laboratory-based high-throughput genomic methods to decipher the genetic information that confers biological function.

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