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Talking Glossary of Genetic Terms

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Lawrence C. Brody, Ph.D. defines Protein

Protein

PROH teen

Proteins are an important class of molecules found in all living cells. A protein is composed of one or more long chains of amino acids, the sequence of which corresponds to the DNA sequence of the gene that encodes it. Proteins play a variety of roles in the cell, including structural (cytoskeleton), mechanical (muscle), biochemical (enzymes), and cell signaling (hormones). Proteins are also an essential part of diet.

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Protein

Proteins are an important class of molecules found in all living cells. A protein is composed of one or more long chains of amino acids, the sequence of which corresponds to the DNA sequence of the gene that encodes it. Proteins play a variety of roles in the cell, including structural (cytoskeleton), mechanical (muscle), biochemical (enzymes), and cell signaling (hormones). Proteins are also an essential part of diet.

Narration Transcription

Many genes in the genome code for proteins. These are molecules of amino acids linked together in a very specific sequence that produce a functional molecule that can fold up to either be an enzyme, or a formed part of the structure of the cell, or to be secreted and act as signals. In all, there are thousands and thousands of proteins that your cells and body makes every single day. In the human genome, there are approximately 20,000 genes that code for proteins.


Doctor Profile

Lawrence C. Brody, Ph.D.

Lawrence C. Brody, Ph.D.

Occupation
Chief & Senior Investigator, Genome Technology Branch; Head, Molecular Pathogenesis Section

Biography
Dr. Brody investigates the genetics of breast cancer and neural tube defects. As chief of the NHGRI Genome Technology Branch's Molecular Pathogenesis section, he is interested in studying genetic mutations that lead to perturbations in normal metabolic pathways and cause disorders such as cancer and birth defects. His laboratory investigates mutations in two breast cancer-linked genes, breast cancer gene 1 (BRCA1) and breast cancer gene 2 (BRCA2). Dr. Brody's laboratory was among the first to report that women carrying BRCA1 or BRCA2 mutations have a higher risk of developing both breast and ovarian cancer than women without such mutations.

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