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Talking Glossary of Genetic Terms

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Elliott Margulies, Ph.D. defines Exon

Exon

EK son

An exon is the portion of a gene that codes for amino acids. In the cells of plants and animals, most gene sequences are broken up by one or more DNA sequences called introns. The parts of the gene sequence that are expressed in the protein are called exons, because they are expressed, while the parts of the gene sequence that are not expressed in the protein are called introns, because they come in between--or interfere with--the exons.

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Exon

An exon is the portion of a gene that codes for amino acids. In the cells of plants and animals, most gene sequences are broken up by one or more DNA sequences called introns. The parts of the gene sequence that are expressed in the protein are called exons, because they are expressed, while the parts of the gene sequence that are not expressed in the protein are called introns, because they come in between--or interfere with--the exons.

Narration Transcription

Exons are that part of the RNA that code for proteins. Now, RNA, when it first gets transcribed, is a very, very long piece of RNA molecule. And really, the important parts of that RNA are the exons. There are large, large chunks of RNA that get excised out. Now, it's important to remember that because I use the term excised doesn't mean that exons go away. The exons are what stay in the mature mRNA and eventually code for amino acids. Many times, including medical students like my wife, will forget whether it's the exons that code for the amino acids or the introns that code for the amino acids. Let me set the record straight that it's the exons that code for the amino acids, because sometimes people try to remember that exons get excised, but that's not true. It's that introns interfere. So you always have to remember that introns interfere, and the introns get excised out of the RNA to leave a string of exons together that will eventually code for the amino acids.


Doctor Profile

Elliott Margulies, Ph.D.

Elliott Margulies, Ph.D.

Occupation
Investigator, Genome Technology Branch; Head, Genome Informatics Section

Biography
Dr. Margulies develops bioinformatical approaches to identifying and characterizing regions of the human genome that are evolutionarily conserved across multiple species. The conservation of these sequences over millions of years of evolution is strong evidence that they play important roles in biology, such as coding for genes or functioning as regulatory elements. He has played an important role in advancing the goals of the NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program. Dr. Margulies's group utilizes both high-performance computational analyses and laboratory-based high-throughput genomic methods to decipher the genetic information that confers biological function.

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