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News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… when two genetic neighborhoods merge in brain tumor cells. Researchers found that one gene came under the control … IDH gene was mutated, particular portions of the cancer cells' DNA became studded with chemical tags called methyl … of these genetic neighborhoods, a gene called PDGFRA makes cells grow, or increase in number, but is rarely turned on. …
Educational Resources
Bacteria are small single-celled organisms.
… and in fact is estimated to contain more bacterial cells than human cells. Most bacteria in the body are harmless, and some are …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… settings, making genomic testing as routine as complete blood counts (CBCs). Speakers: Jennifer Posey, M.D., Ph.D., … and cellular dataset to help scientists understand how cells respond to specific biological and environmental … LINCS program generated dataset to help understand how cells functio …
Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
… of DNA and other molecules that may be retained as cells divide to make more cells. … of DNA and other molecules that may be retained as cells divide to make more cells. When found in DNA, methylation can alter gene … of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of …
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
Fact Sheets
Chromosomes are thread-like structures located inside the nucleus of animal and plant cells.
… structures located inside the nucleus of animal and plant cells. … structures located inside the nucleus of animal and plant cells. Each chromosome is made of protein and a single … packaging, DNA molecules would be too long to fit inside cells. For example, if all of the DNA molecules in a single …
Educational Resources
Haploid is the quality of a cell or organism having a single set of chromosomes.
… presence of a single set of chromosomes in an organism’s cells. Sexually reproducing organisms are diploid (having two … one from each parent). In humans, only the egg and sperm cells are haploid. …
Educational Resources
The instructions in a gene that tell the cell how to make a specific protein.
News Release
Cell Press' "Best of AJHG 2017-2018" includes an article authored by CRGGH researchers Daniel Shriner and Charles Rotimi.
… of when and how the mutation that causes "sickling" of red blood cells arose ( previous blog post ). This work captured …