Search Results
Research Funding
The Genomic Variation Program supports large-scale studies of human genetic variation.
… About 99.5 percent of a person's DNA is the same as any unrelated person's DNA. … the sequence of DNA among individuals are called genetic variation. Genomic variation explains some of the differences among …
Event
NHGRI workshop seeking scientific perspectives for relating genomic variation to human phenotype.
… and Introduction Eric Green 8:40 - 9:00 a.m. Statement of Meeting Goals Elise Feingold Adam Felsenfeld Part I: … 2 ( Madison Room ) How and why to approach structural variation and other "hard to measure" variation? Co-Chairs : … strategy to advance our ability to find and characterize genomic variants, the genomic elements in which they reside …
Fact Sheet
Genomic variation accounts for some of the differences among people, including important aspects of their health and susceptibility to diseases.
… The Big Picture  Genomic variation reflects the differences in a person’s DNA … compared to other peoples’ DNA.  There are multiple types of variants in human genomes, ranging from small differences … person’s genome, but a small subset of variants do have an impact. For example, some genomic variants influence physical …
Research at NHGRI
The Translational and Functional Genomics Branch explores the genetic, epigenetic and metagenomic basis of human disorders.
… Genomics Branch (TFGB) studies how genome structure and function contribute to health by exploring the genetic, epigenetic and metagenomic basis of human disorders. … TFGB researchers have developed a wide … aspects of the genomes of humans, microorganisms that live on humans and animal models of genetic disease. TFGB …
News Release
A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… Steven Benowitz … A relatively new method of targeting specific DNA sequences in zebrafish could … National Institutes of Health. … In a study posted online on June 5, 2015, and to be published in the July 2015 issue … in an animal model could be particularly useful for human genomic research. Only 10 to 20 percent of recognized human …
Educational Resources
A copy number variation (CNV) is when the number of copies of a particular gene varies from one individual to the next.
… Copy Number Variation (CNV) … A copy number variation (CNV) is when the number of copies of a particular gene varies from one individual to the next. …
News Release
Researchers identified regions of the genome associated with skin color variation in some African populations, furthering skin disease and cancer research.
… Jeannine Mjoseth … In the first study of its kind, an international team of genomics researchers … of the human genome that are associated with skin color variation in some African populations, opening new avenues … pigmentation, researchers could learn about the underlying genomic alterations that were responsible for difference in …
Jobs at NHGRI
Funded postdoctoral positions are available in the laboratory of Dr. Shawn Burgess, within NHGRI's Translational and Functional Genomics Branch.
… postdoctoral positions are available in the laboratory of Shawn Burgess, Ph.D., within the Translational and … of Health (NIH). … The focus of the Burgess lab is on the genetics and functional genomics of tissue … mutagenesis approaches, computational analysis of genomic data at multiple levels of genome organization, and …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… and heart disease usually stem from a complicated mix of genetics and lifestyle. While changes in many genes … gene activity. … To paint a clearer picture of how such variation affects gene activity, Fernando Pardo Manuel de … Jeffrey Struewing, M.D., program director, Division of Genomic Medicine, NHGRI; Andrea Beckel-Mitchener, Ph.D., …
Research Funding
Frequently Asked Questions for IGVF RFAs: RFA-HG-20-043, RFA-HG-20-044, RFA-HG-20-045, RFA-HG-20-046, RFA-HG-20-047
… from initial ideas to detailed specific aims. A summary of ideas or preferably a draft of specific aims would be a … but must be justified by potential to learn about the impact of genomic variation on networks substantially beyond what could …