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Educational Resources
Translation is the process of translating the sequence of a messenger RNA (mRNA) molecule to a sequence of amino acids during protein synthesis.
… place on ribosomes in the cell cytoplasm, where mRNA is read and translated into the string of amino acid chains that …
Infographic
An infographic that explains why it was so difficult to fully complete the human genome sequence.
… by a letter (G, A, T or C). A genome's sequence cannot be read out end-to-end. Rather, researchers must first determine … two decades, researchers developed new technologies to read longer stretches of DNA - from only about 500 to now … repeats. The lady on the left is holding a short read sequence of a chromosome (Chromosome 1) and asks "Where …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… but also structural variants. That’s thanks to the long-read DNA sequencing technologies that we have now. The …
For Teachers
Tools and resources for teaching the concepts of transcription and translation, two key steps in gene expression
… case" was designed to develop students' ability to read and interpret information stored in DNA. Making use of … exported from the nucleus, and finally how the RNA code is read to build proteins. Animation: The Central Dogma A Prezi …
Statement
NHGRI Director, Eric Green, M.D, Ph.D., provides remarks for the March 31, 2022 media briefing about the series of publications reporting the first complete, gapless sequence of a human genome.
… repetitive stretches of letters that are difficult to read and difficult to put in the right place in the overall … have emerged, among then methods that allow researchers to read much longer stretches of DNA at a time — from only about … And so missing piece by missing piece, the T2T team read and assembled these really rugged, repetitive bits …
The Genomics Landscape
In the December 2018 edition of The Genomics Landscape, NHGRI Director Eric Green recaps progress from NHGRI strategic planning process events in 2018.
… will keep us just as busy. In particular - and as you will read below - the NHGRI strategic planning process is in full …
News Release
Researchers have released a new high-quality collection of reference human genome sequences that captures substantially more diversity from different human populations than what was previously available.
… especially in areas that were repetitive and hard to read. Recent technological advances such as long-read DNA sequencing, which reads longer stretches of the DNA … variants that exist in each human genome using short-read sequencing due to the bias of using a single reference …
News Release
NIH lost a key member of its broader genomics team when Robert Blakesley, Ph.D., director of the NISC sequencing group at NIH, retired on Dec. 31, 2015.
… system. A turning point came in the fall of 1963 when he read a long Los Angeles Time article on about the 10th … discovery of the double helical structure of DNA. "Once I read that article, I wanted to know how genes worked. It …
Professional Development Programs
The JHU/NHGRI Genetic Counseling Training Program trains students to conduct research and provides clinical rotations to learn about genetic conditions.
… Neurogenetics Genetic Counseling Clinic Julie Cohen, Sc.M. Rebecca McClellan, M.G.C. Maternal Fetal Medicine Associates …
15 Ways Genomics Influences Our World
We are learning how our genomes serve as blueprints for life.
… What is the rest of it doing? And how does each cell read and interpret its genome? … Although it's appealing to … or proteins that bind to DNA that change the way genes are read. Such modifications can be passed on as cells divide, … can act like mutations by directing if the bases are read or not.. For example, in cancer cells, methyl groups are …