Search Results
The Genomics Landscape
In May 4, 2023 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., details a report released by the National Academies of Science, Engineering, and Medicine, that provided a series of recommendations for using population descriptors in future genetics and genomics studies.
… scientific progress, the terms used to describe human populations have remained stuck in the past. Genetics and … reproducibility of research studies and ensure that all populations benefit from genomic advances. The scientific and …
News Release
NIH-backed African scientists are engaged in a global research endeavor to understand the genetic basis of disease in all populations.
… endeavor to understand the genetic basis of disease in all populations. But this can only be done by including populations that are the most genetically diverse. … A Global Research Endeavor Studies have shown that African populations contain the oldest and most diverse set of human …
News Release
NIH will fund grants totaling $38 million over five years to develop methods that will improve the way that polygenic risk scores can be used to predict disease in diverse communities.
… were developed using data from mostly European ancestry populations, are not effective when used in diverse populations. The new consortium, called PRIMED , will pool … that the scores accurately predict disease across diverse populations. Researchers have used available large-scale …
News Release
NIH-funded research highlights need for diversity in study populations, creates a comprehensive genomic toolkit for scientists
… NIH-funded research highlights need for diversity in study populations, creates a comprehensive genomic toolkit for … cigarette use and chronic kidney disease in diverse populations. The team collected data from 49,839 … variants and specific diseases in European ancestry populations could be detected in African-American, …
Research at NHGRI
CRGGH facilitates understanding of the relationship between genetic variation and population differences in disease distribution to inform health disparities.
… patterns and determinants of common complex diseases in populations in the United States and around the world. … … dyslipidemia, and kidney diseases, in different human populations with particular attention to African Americans … the analysis of data generated in Africans and other populations.  Investigate how knowledge and understanding of …
News Release
NHGRI researchers and their collaborators, have successfully used facial analysis software to diagnose Noonan syndrome in Africans, Asians and Latin Americans.
… in NHGRI's Medical Genetics Branch . Although from diverse populations, the participants in the study had some common … Indian subcontinent, the Middle East, South America and sub-Saharan Africa. In addition to the photos, the atlas will …
News
To prevent an emerging genomic technology from contributing to health disparities, a scientific team funded by the National Institutes of Health has devised new ways to improve a genetic testing method called a polygenic risk score.
… polygenic risk scores have not been effective for all populations, the researchers recalibrated these genetic tests … a more accurate assessment of disease risk across diverse populations. Genetic tests look at the small differences … many individuals with ancestry spanning two or more global populations. Strong representation of these individuals is …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… cause common periodic fever have spread in Mediterranean populations over centuries, potentially protecting people … plague. … Researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory … have been positively selected for in Mediterranean populations over centuries. The findings were published in …
Media Availability
Type 2 diabetes is a disease that affects ten percent of the world's population, but the genetics underlying the disease remain poorly understood.
… genetic changes, known as variants, are distributed among populations and how they lead to increased risk. Functional …
Research Funding
The Multi-Omics for Health and Disease Consortium aims to advance the application of multi-omic technologies to study health and disease in ancestrally diverse populations.
… to study health and disease in ancestrally diverse populations. … While single ‘omic analyses have produced … and standards that can be generalized across diseases and populations. It will also generate a standardized and … to study health and disease in ancestrally diverse populations. By leveraging disease contexts where multi-omic …