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News Release
An expert panel from the Clinical Genome Resource (ClinGen) has critically reevaluated the scientific evidence for all 17 reported genes, disputing nine of the genes and revealing only three of the genes to be definitively associated with the most common form of the disease.
… ClinGen panel also validates three genes believed to be associated with long QT syndrome … Geneticists and heart … and revealing only three of the genes to be definitively associated with the most common form of the disease. The work … reporting to physicians. Published papers reporting gene-disease associations vary widely in their study design …
News Release
Researchers funded by NIH have completed a detailed atlas documenting stretches of human DNA that influence gene expression.
… documenting the stretches of human DNA that influence gene expression - a key way in which a person's genome gives … scale used by GTEx that enabled researchers to study how gene expression in the liver might be different than in the … are identified by establishing which specific variants are associated with differences in gene expression levels. The …
News Release
NIH researchers have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), found that individuals diagnosed with ADHD had differences in genes that code for known chemicals that brain cells use to communicate.
… Health (NIH) have successfully identified differences in gene activity in the brains of people with attention deficit … gene expression . They studied two connected brain regions associated with ADHD: the caudate and the frontal cortex. … advances, researchers have been able to identify genes associated with ADHD, but they had not been able to determine …
Educational Resources
Nucleic acids are large biomolecules that play essential roles in all cells and viruses.
… … Nucleotide, Genetic Code, DNA, Deoxyribonucleic Acid, Gene Expression … Nucleic acids are large biomolecules that …
Community Outreach
NHGRI is proud to help support the PBS documentary, “Ken Burns presents The Gene: An Intimate History,” based on the book by Siddhartha Mukherjee, M.D.
… help support the PBS documentary, “Ken Burns presents The Gene: An Intimate History,” based on the book by Siddhartha Mukherjee, M.D. The Gene aired April 7 and 14 at 8:00 p.m. ET. The series, based … the history of science. … In this fun animated series, the gene’s complex mechanisms are explored in simple ways. … …
News Release
As researchers uncover millions of DNA differences in genes, doctors struggle to know which of these inherited differences, called variants, really matter.
… of lab results with uncertain findings about whether a gene or variant is disease-causing," said Jonathan Berg, … basic questions: Is there a true relationship between a gene and disease? Does the genetic variant in a gene cause or contribute to disease? For a person who has one …
Fact Sheet
Viruses are bundles of genetic material wrapped in a protein coat that can infect living things.
… as being bitten by a mosquito infected with the West Nile virus. When viruses (and other pathogens) move from one … lock. When the key meets the lock, it opens a door for the virus to enter the cell. Viruses enter host cells as … being capable of infecting another cell. Once a virus successfully replicates itself, it leaves the host cell …
Educational Resources
A retrovirus is a virus that uses RNA as its genetic material.
… Retrovirus … A retrovirus is a virus that uses RNA as its genetic material. … Acquired … (DNA), Genome, Ribonucleic Acid (RNA) … A retrovirus is a virus that uses RNA as its genomic material. Upon infection … which infect other cells. Many retroviruses are associated with diseases, including AIDS and some forms of …
News Release
NIH researchers have identified a gene that makes yeast resistant to a lethal toxin.
… Newly discovered gene helps some yeast endure toxins and can help scientists … study, NHGRI researchers analyzed yeast infected with a virus that causes the yeast to secrete a lethal toxin called K28. The virus does not negatively affect the infected yeast. Instead, …
News Release
NIH is launching a program, Molecular Phenotypes of Null Alleles in Cells (MorPhiC), to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene.
… a program to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene. The Molecular Phenotypes of Null Alleles in Cells … aims to systematically investigate the function of each gene through multiple phases that will each build upon the …