Search Results
Summit
This Summit is a 5-year initiative (2016-2020) designed to help developing nations build and expand their knowledge base, infrastructure, systems, research efforts and technologies in human genetics and genomics.
… healthcare system in developing nations for the provision, delivery and management of safe genetic services (CLIA-like …
Fact Sheets
Cloning describes a number of different processes that can be used to produce genetically identical copies of a biological entity.
… The great advantage of using cloned animals for drug testing is that they are all genetically identical, … scientists and experts in cloning, the U.S. Food and Drug Administration (FDA) decided in January 2008 that meat …
Clinical Research
The Institutional Review Board (IRB)Â is responsible for protecting the rights and welfare of the human subjects of research protocols that are conducted by intramural investigators in NHGRI and a number of other institutes.
… Sponsors  FDA Investigator-Initiated Investigational New Drug (IND) Applications  Other Organizations Public …
Genetic Disorders
Familial Mediterranean Fever is an inherited disease, characterized by recurrent attacks of fever, inflammation, painful, swollen joints, and ankle rash.
… the disease. A common therapy for FMF is daily use of the drug colchicine, a medicine that reduces inflammation. This … attacks of fever in 75 percent of patients who take the drug regularly, and over 90 percent of patients demonstrate a … every day is very important. If a patient stops taking the drug, an attack can occur within a couple of days. Since the …
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
… to survive childhood. But today, due to preventive drug treatment, improved medical care and aggressive … antibiotics, pain management and blood transfusions. A new drug treatment, hydroxyurea, which is an anti-tumor drug, appears to stimulate the production of fetal …
Profile
Carlos Ferreira, M.D., staff clinician in NHGRI's Metabolic Medicine Branch, knows the catalogue of rare skeletal disorders well. With hundreds of known rare bone disorders and more to be discovered, Dr. Ferreira breaks down the challenges of skeletal genomics.
… are in the process of running a clinical trial to test a drug that acts on the receptor. … Soo: What are you looking …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… this hypothesis by adding 5-Azacytidine, a chemotherapy drug that disrupts formation of methyl tags, to glioma cells. …
Fact Sheets
Genomics is the study of all of a person's genes (the genome), including interactions of those genes with each other and with the person's environment.
… studies needed to receive approval from the Food and Drug Administration. Screening and diagnostic tests, however, … about a patient's genetic make-up to better tailor drug therapy to their individual needs. Clearly, genetics …
Genetic Disorders
The porphyrias are a group of different diseases, each caused by a specific abnormality in the heme production process.
The Genomics Landscape
In the May 2024 issue of The Genomics Landscape, NHGRI Director Eric Green talks about the NHGRI Research Training and Career Development Annual Meeting, which provides a venue to foster support and a sense of community for NHGRI-funded trainees, equipping them with tools for success and more clarity about career possibilities.
… anniversary of the fellows program. … Genomics Research Drug shows promise for slowing progression of rare, painful …