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News Release
NIH has awarded grants of more than $28 million aimed at deciphering the language of how and when genes are turned on and off.
… than $28 million aimed at deciphering the language of how and when genes are turned on and off. These awards emanate from the … of NIH. … "There is a growing realization that the ways genes are regulated to work together can be important for …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… of the Journal of Clinical Investigation . … "Effective and safe gene therapies have the potential to dramatically … But one prior study did find an association between AAV and the occurrence of liver cancer. The present research … not insert where it would elevate the expression of nearby genes and it did not cause liver cancer. The researchers …
News Release
An expert panel from the Clinical Genome Resource (ClinGen) has critically reevaluated the scientific evidence for all 17 reported genes, disputing nine of the genes and revealing only three of the genes to be definitively associated with the most common form of the disease.
… Ph.D. … NIH-funded ClinGen panel also validates three genes believed to be associated with long QT syndrome … Geneticists and heart specialists around the world had previously reported 17 genes to cause long QT syndrome, a little-known inherited …
News Release
NIH researchers have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), found that individuals diagnosed with ADHD had differences in genes that code for known chemicals that brain cells use to communicate.
… that individuals diagnosed with ADHD had differences in genes that code for known chemicals that brain cells use to … brain, which allows researchers to examine the structure and activation of brain areas. However, these studies lack … reflect differences in how the brain functions, such as in autism.” Importantly, the researchers found that these …
Fact Sheet
Understanding gene therapy for sickle cell disease
… sickle cell disease. Now, researchers are developing new and emerging gene therapies to treat sickle cell disease. To … therapies, more than 50 scientists, physicians, patients and other experts worked together to develop content for the … is led by NHGRI in partnership with other organizations and individuals. This group met over the course of four …
News Release
Researchers funded by NIH have completed a detailed atlas documenting stretches of human DNA that influence gene expression.
… variation leads to biological differences, like healthy and diseased states, across human tissues and cell types. … … to catalog how genomic variation influences how genes are turned off and on. "GTEx was unique because its … explored how genomic variation affects the expression of genes in individual tissues, across many individuals, and …
News Release
Scientists are using an exciting gene editing tool called CRISPR/Cas9 to protect plants from harmful DNA viruses, strengthening the plant's protections.
… has previously been adapted for use in many organisms, and this latest iteration develops gene-editing for use in … plant genomics is valuable for human nutrition and health. In addition to playing an essential role in our ecosystem, plants sustain our bodies and economies. Crop losses, particularly due to DNA plant …
Community Outreach
NHGRI is proud to help support the PBS documentary, “Ken Burns presents The Gene: An Intimate History,” based on the book by Siddhartha Mukherjee, M.D.
… book by Siddhartha Mukherjee, M.D. The Gene aired April 7 and 14 at 8:00 p.m. ET. The series, based on Mukherjee’s … free, print-on-demand exhibit consists of graphic panels and interactive media. It can be adapted to a variety of … the stunning breakthroughs in understanding the impact genes play on heredity, disease and behavior. … The Gene: An …
News Release
As researchers uncover millions of DNA differences in genes, doctors struggle to know which of these inherited differences, called variants, really matter.
… Steven Benowitz … As a growing number of medical centers and laboratories are sequencing patients' DNA, they continue to uncover millions of DNA differences in genes and the regions between the genes. But doctors have struggled to know which of these …
Educational Resources
Gene therapy is an experimental technique for treating disease by altering the patient's genetic material.
… gene. Both inherited genetic diseases (e.g., hemophilia and sickle cell disease) and acquired disorders (e.g., leukemia) have been treated …