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News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… and genetic factors - that are potentially disruptive to cells. LINCS researchers then will measure the cells' tiniest molecular and biochemical responses, and use … common patterns, as well as uncommon behavior, in how cells respond to being exposed to various small molecules, …
Talking Glossary
Chromosomes are threadlike structures made of protein and a single molecule of DNA that serve to carry the genomic information from cell to cell.
… (including humans), chromosomes reside in the nucleus of cells. Humans have 22 pairs of numbered chromosomes …
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
Talking Glossary
A gamete is a reproductive cell of an animal or plant.
… or plant. In animals, female gametes are called ova or egg cells, and male gametes are called sperm. Ova and sperm are haploid cells, with each cell carrying only one copy of each …
News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… Medicine that they have succeeded in coaxing cultured cells to exhibit the signature traits of the disease. Using … that has successfully corrected the malfunctioning cells. … Gaucher disease is an inherited condition caused by … of the liver and spleen, a low number of red blood cells, easy bruising caused by a decreased blood platelets, …
Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
… of DNA and other molecules that may be retained as cells divide to make more cells. … Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. When found in DNA, …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… and cellular dataset to help scientists understand how cells respond to specific biological and environmental … LINCS program generated dataset to help understand how cells functio … NHGRI and NCI award $33 million to improve … LINCS program generated dataset to help understand how cells function … In the July 2021 issue of The Genomics …
Fact Sheets
Chromosomes are thread-like structures located inside the nucleus of animal and plant cells.
… structures located inside the nucleus of animal and plant cells. … Chromosomes are thread-like structures located inside the nucleus of animal and plant cells. Each chromosome is made of protein and a single … packaging, DNA molecules would be too long to fit inside cells. For example, if all of the DNA molecules in a single …
Educational Resources
Haploid is the quality of a cell or organism having a single set of chromosomes.
… presence of a single set of chromosomes in an organism’s cells. Sexually reproducing organisms are diploid (having two … one from each parent). In humans, only the egg and sperm cells are haploid. … Haploid is the quality of a cell or …