Search Results
Research Funding
NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.
… characterization of variants underlying heart and blood diseases with CRISPR base editing HG012010 Charles … Gersbach Gregory Crawford Tim Reddy Duke University High-throughput functional annotation of gene regulatory … to identify putative candidate regulatory elements with high likelihood of functional links to disease-relevant gene …
News Release
NHGRI researchers identified 59 genes or gene regions linked to canine athletics.
… including those with roles in endurance, heart function, blood flow and pain perception. What terriers lacked in … athletic outcomes. They include genes that regulate blood pressure, muscle size, oxygen use and fatigue …
For Patients and Families
​Genetic research is creating new ways for people to take action and prevent disease and new ways to treat disease through personalized medicine.​ ​
… anemia also run in families. For example, if a parent has high blood pressure, his or her child is more likely to have high blood …
News Release
NHGRI researchers and their international collaborators have added Williams-Beuren syndrome to the Atlas of Human Malformation Syndromes in Diverse Populations.
… associated with the syndrome are a narrowing of the large blood vessel that carries blood from the heart to the rest of the body ( supravalvular aortic stenosis ) and high blood pressure. The cover of this month's issue of the American …
Jobs at NHGRI
An NIH-funded postdoctoral position is available in the Childhood Complex Disease Genomics Section (CCDGS), a new section in the Center for Precision Health Research at NHGRI, under Dr. Neil Hanchard.
… undernutrition, sickle cell disease, and early-onset high blood pressure - in African- and African-ancestry populations. The …
Genetic Disorders
Antiphospholipid Syndrome is a disorder characterized by elevated levels of antibodies that are associated with clots in the arteries and veins.
… I (ß2GPI, a normal protein found in the blood whose function is unknown) and another molecule known … noted in association with APS. Pulmonary hypertension (high blood pressure in the arteries that supply the lungs) and …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… and faith-based institutions in the area. Given the high burden of CVD among AA, this approach will yield a … that includes: medical evaluation (e.g. anthropometrics, blood pressure), laboratory tests (e.g. lipid levels, kidney …
FAQ
On November 8-9, 2023, NHGRI sponsored its 15th Genomic Medicine meeting, Genomic Medicine XV: Genomics and Population Screening, in Bethesda MD. The following questions were answered during the meeting.
… screening come before our ability to discern clinically high-risk people? Or address the disparities on the back-end … in advance. Fortunately, many interventions to lower blood pressure, including medication and diet/lifestyle changes, …
Staff
Dr. Adebowale Adeyemo is an associate investigator and deputy director of NHGRI's Center for Research on Genomics and Global Health.
… genome-wide association study (GWAS) for hypertension and blood pressure in African Americans. Dr. Adeyemo is currently … mapping panels for African Americans from commercial high-density SNP arrays. BMC Genomics, 11:417. 2010. [ PubMed …
File
… Slides_Variation in Blood Pressure Across Populations.pdf …