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… Slides_Variation in Blood Pressure Across Populations.pdf …
News Release
NIH researchers have created a data resource show how differences in an individual's genome can affect gene activity and contribute to disease.
… a resource that scientists studying areas ranging from blood pressure to neurodegenerative disease would find invaluable." … collaboration and supports a series of exceptionally high-impact, trans-NIH programs. Common Fund programs are …
News Release
NIH researchers have identified a gene that makes yeast resistant to a lethal toxin.
News Release
NHGRI researchers seek help from people with Sickle Cell Disease to find the factors - environmental, social and genetic - that impact the severity of symptoms.
… ulcers. These and other symptoms result when mutated red blood cells take a sickle shape, blocking blood flow and decreasing oxygen delivery. Little is known … aim to improve our understanding of the disease." Normal blood cells (left) and the blood cells in Sickle cell …
Genetic Disorders
Marfan syndrome an inherited disorder of connective tissue occurring once in every 10,000 to 20,000 individuals.
… enlargement of the proximal pulmonary artery, and a high risk for aortic tear and rupture (aortic dissection). … … Recent work on Angiotensin II receptor blockers, another blood pressure medication like beta blockers, has shown additional …
Profile
In a conversation, Dr. Elise Feingold reflects on her path to NHGRI, describes her experience leading the ENCODE program and shares advice for those considering different scientific careers.
… become interested in science and genetics? Feingold: In high school, I took a biology class, and I just really … to be postdoctoral fellow at National Heart, Lung, and Blood Institute. While I really loved the science, I didn't … to identify genomic targets for developing treatments for blood disorders that Dr. Feingold had studied decades …
Genetic Disorders
Dercum disease is a rare condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of middle age.
… cyanosis (bluish discoloration of the skin), hypertension (high blood pressure), headaches, and epistaxis (nosebleeds). … The …
Staff
Dr. Rongling Li is an epidemiologist and program director in the Division of Genomic Medicine at the National Human Genome Research Institute.
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… JC, Kenny EE, Bottinger EP. Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans. J Am Coll Cardiol . … CA McCarty, R Li, TA Manolio, DC Crawford, RL Chisholm. High density GWAS for LDL cholesterol in African Americans …
The Genomics Landscape
In the July 2019 edition of The Genomics Landscape, NHGRI Director Eric Green reflects on the milestones of the Newborn Sequencing in Genomic Medicine and Public Health (NSIGHT) Program as it reaches completion.
… of the genome that reflects protein-coding regions), used blood spots and saliva as the source of DNA, enrolled healthy … conditions. Since these conditions have disproportionately high morbidity and mortality in non-European populations, … NIH Scientists Link Genetics to Risk of High Blood Pressure Among Blacks Notable Accomplishments in Genomic …
News Release
NIH-funded research highlights need for diversity in study populations, creates a comprehensive genomic toolkit for scientists
… 27 new genomic variants associated with conditions such as blood pressure, type II diabetes, cigarette use and chronic kidney … American populations.  Credit: Ernesto del Aguila III. High-resolution image on Flickr.  Their findings show that …