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Staff
Darryl Leja is a senior graphic designer, illustrator and visual information specialist within NHGRI's Office of Communications.
… entitled "Training in Basic Biomethodology for Laboratory Mice," DNA Day, the Genome Unlocking Life’s Code Exhibit on …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
File
… Knockout Mouse Phenotyping Program Concept Clearance (May …
Staff
Dr. Paul Liu is a senior investigator in NHGRI's Translational and Functional Genomics Branch.
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… et al., Cell 1996). Using the Cbfb-MYH11 knock-in mice (in which human MYH11 was inserted into mouse Cbfb to … by microarray analysis with cells from Cbfb-MYH11 knock-in mice, and identified leukemia-initiating cells using these … Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukemia. Nat Genet, 23:144-146. …
News Release
The largest genomic study on type 2 diabetes in Africans to date has recently been published in Nature Communications and reports the most recent findings of the ongoing Africa America Diabetes Mellitus (AADM) study that has been led by Dr. Charles Rotimi for over two decades.
… functional studies of this locus in zebrafish and mice, researchers discovered that ZRANB3 plays a role in the …
Fact Sheets
Cloning describes a number of different processes that can be used to produce genetically identical copies of a biological entity.
… 1979, researchers produced the first genetically identical mice by splitting mouse embryos in the test tube and then … the resulting embryos into the wombs of adult female mice. Shortly after that, researchers produced the first … cell division. In other mammals, such as cats, rabbits and mice, the two spindle proteins are spread throughout the egg. …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… in basic research. Editing the genomes of yeast, bacteria, mice, zebrafish, and other organisms that scientists commonly … and price. … [1] Capecchi, M. R. (2005). Gene targeting in mice: functional analysis of the mammalian genome for the …
Staff
Dr. Michael Erdos is an Associate Investigator in the Molecular Genetics Section of the Center for Precision Health Research.
… successful at reducing the cardiovascular defects in young mice. In addition, it improved the cardiovascular histopathology when administered to older mice. This work supported the first clinical trial … C/T DNA base editors are capable of systemic delivery in mice and can achieve 8-30% mutation correction in critical …
Staff
Dr. Francis Collins is a senior investigator in Center for Precision Health Research.
… the disease seen in HGPS patients. Specifically, these mice exhibit progressive loss of vascular smooth muscle cells … prevented the onset of cardiovascular disease in young mice but also reduced the progression of the cardiovascular defects upon treatment of older mice. This research complemented other data in support of a …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… also the genomes of important research organisms, such as mice, C. elegans and zebrafish. Throughout the Human Genome …