Search Results
Staff
Elaine Ostrander is chief of NHGRI's Cancer Genetics and Comparative Genomics Branch.
… is Chief and Distinguished Senior Investigator of the Cancer Genetics and Comparative Genomics Branch at the … Cancer Research Center and University of Washington in 1993, rising to the rank of Member in the Human Biology and Clinical Research Divisions, and …
Staff
Dr. Lawrence Brody is a senior investigator in NHGRI's Social and Behavioral Research Branch and director of NHGRI's Division of Genomics and Society.
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… inherited components of human disease. He is interested in studying genetic mutations that lead to perturbations in normal metabolic pathways and cause disorders such as cancer and birth defects. His laboratory focuses on …
Educational Resources
An oncogene is a mutated gene that contributes to the development of a cancer.
… is a mutated gene that contributes to the development of a cancer. … Carcinogen, Mutagen, Cancer, Cell, Mutation, Tumor … it is called a proto-oncogene, and it plays a role in regulating normal cell division. Cancer can arise when a … Some oncogenes work like an accelerator pedal in a car, pushing a cell to divide again and again. Others …
Genetic Disorders
Gaucher disease is an autosomal recessive inherited disorder of metabolism where a type of fat (lipid) called glucocerebroside cannot be adequately degraded.
… This causes the specific lipid to build up in the liver, spleen, bone marrow and nervous system … within the three Types. Gaucher disease is caused by changes (mutations) in a single gene called GBA . Mutations … problems, enlarged liver and spleen (hepatosplenomegaly), changes in red blood cell levels, easy bleeding and bruising …
News Release
NIH researchers searched for how the body signals the lack of oxygen in melanoma skin cancer.
… Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) … Genome Research Institute, a part of NIH. "In addition, changes in how the genes are expressed (turned on or off) …
Educational Resources
BRCA1 and BRCA2 are the first two genes found to be associated with inherited forms of breast cancer.
… found to be associated with inherited forms of breast cancer. … Breast Cancer, Prostate Cancer, Genetic Mutation, … of breast cancer and ovarian cancer. People with mutations in either BRCA1 or BRCA2 have a much higher risk for … or other types of cancer than those without mutations in the genes. Both BRCA1 and BRCA2 normally act as tumor …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted … to kidney failure. MMA patients also suffer from severe metabolic instability, failure to thrive, intellectual and …
Profile
Carlos Ferreira, M.D., staff clinician in NHGRI's Metabolic Medicine Branch, knows the catalogue of rare skeletal disorders well. With hundreds of known rare bone disorders and more to be discovered, Dr. Ferreira breaks down the challenges of skeletal genomics.
… my last year of high school, I decided to pursue a career in medicine because I found it challenging and stimulating … patients with Saul-Wilson syndrome have the same genomic changes and similar clinical signs and symptoms. The disorder … Carlos Ferreira, M.D. , a staff clinician in the Metabolic Medicine Branch at the National Human Genome …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
… have created a promising new method to accurately and, in some cases, more comprehensively analyze and interpret DNA sequence information from cancer patients. They have developed an algorithm that sorts … help guide individualized patient treatment or enrollment in clinical trials that test a therapy aimed at a particular …
Educational Resources
Epigenetics is an emerging field of science that studies heritable changes caused by the activation and deactivation of genes without any change in the underlying DNA sequence of the organism.
… is an emerging field of science that studies heritable changes caused by the activation and deactivation of genes without any change in the underlying DNA sequence of the organism. … … called epigenomics) is a field of study focused on changes in DNA that do not involve alterations to the …