Research Fellow

Center for Research on Genomics and Global Health

Education

B.S. University Claude Bernard, 1997

Ph.D. Howard University, 2008

Biography

Dr. Ayo Doumatey is currently a Research Fellow and Laboratory Manager at the Center for Research on Genomics and Global Health (CRGGH), National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH). She joined Dr. Rotimi's team at NIH to continue serving the scientific community and to further her training in Genetic Epidemiology of complex diseases, in particular obesity and related traits.

Her primary research focuses on understanding the involvement of inflammatory markers and adipocytokines in the development of obesity related co-morbidities especially in populations of the African Diaspora. She has been using different strategies to study the complex molecular basis of obesity and obesity-related traits mainly adipokine profiling, whole genome gene expression profiling, genome-wide association studies, proteomics, and whole exome sequencing (WES).

Dr. Doumatey also supports the research activities of her peers within the Center by designing and performing experiments pertinent to their research goals. She also manages all laboratory projects through their life cycles as well as maintaining all laboratory equipment.

Dr. Doumatey received a doctorate in Medical Microbiology from Howard University in Washington D.C. while serving as Research Laboratory Manager for the Genetic Epidemiology Unit of the National Human Genome Center at Howard University (2000-2008). As Laboratory Manager, she supported and coordinated the center’s research efforts both locally and internationally. Using her multidisciplinary skills, she set up a laboratory within the newly created genome center to efficiently handle the increasing biochemical, molecular, and bio- repository activities. She trained and mentored a number of high school, post-baccalaureate, and graduate students. Her expertise in molecular biology, laboratory science, and biorepository management has allowed her to serve as Laboratory Director for the Black Women Health Study (BWHS), a large national follow-up study of 59,000 women. She also assisted the General Clinical Research Center’s investigators at the Howard University Hospital in their laboratory needs. This tenure has given her the opportunity to work on a range of health conditions that disproportionally affect populations of the African Diaspora, including type 2 diabetes, hypertension, and obesity.

After earning a Bachelor's degree in biochemistry with a minor in microbiology from Université Claude Bernard in Lyon, France, Dr. Doumatey pursued her Master's degree in biochemistry with focus on cellular and molecular endocrinology at the same school. Thereafter, she attended the School of Pharmacy at Université Claude Bernard (medical campus) for one year to specialize in quality assurance (QA) and quality control (QC). While completing her specialization, she worked as QA/QC consultant for a medical and clinical laboratory group in Lyon, France. Before moving to the United States, she also served as a quality assurance/quality control analyst for vaccine production at the Institute Pasteur Merieux Connaught in Marcy-l'Etoile, France.

Curriculum Vitae

Publications

Bentley AR, Chen G, Shriner D, Doumatey AP, et al. Gene-based sequencing identifies lipid-influencing variants with ethnicity-specific effects in African Americans. PLoS Genet. 2014 Mar 6; 10(3):e1004190. Doi: 10.1371/journal.pgen.1004190. ECollection 2014.

Doumatey AP, Zhou J, Adeyemo A, Rotimi C. High sensitivity C-reactive protein (Hs-CRP) remains highly stable in long-term archived human serum. Clin Biochem. 2014 Mar; 47(4-5):315-8. Doi: 10.1016/j.clinbiochem.2013.12.014. Epub 2013 Dec 27.

Ramos E, Doumatey A, et al. Pharmacogenomics, ancestry and clinical decision making for global populations. Pharmacogenomics J. 2013 Jul 9. doi: 10.1038/tpj.2013.24

Famooto A, ---- Doumatey A et al. RPS19 and TYMS SNPs and Prevalent High Risk Human Papilloma Virus Infection in Nigerian Women. PLoS One. 2013 Jun 27; 8(6):e66930

Doumatey, AP et al. Paradoxical Hyperadiponectinemia is Associated with the Metabolically Healthy Obese (MHO) Phenotype in African Americans. J Endocrinol Metab. 2012 April; 2(2):51-65

Doumatey, AP et al. Circulating Adiponectin is associated with Renal Function Independent of Age and Serum Lipids in West Africans. Int J Nephrol. 2012; 2012:730920. Epub 2012 Aug 22

Doumatey AP, et al. C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. Hum Mol Genet. 2012 Apr 18.

Tekola Ayele F, Doumatey A et al. Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans. Immunogenetics. 2012 May; 64 (5):351-9. Epub 2011 Dec 29.

Charles BA, Doumatey A et al. The roles of IL-6, IL-10, and IL-1RA in obesity and insulin resistance in African-Americans. J Clin Endocrinol Metab. 2011 Dec; 96 (12):E2018-22. Epub 2011 Sep 28.

Meilleur KG, Doumatey A et al. Circulating adiponectin is associated with obesity and serum lipids in West Africans. J Clin Endocrinol Metab. 2010 Jul; 95(7):3517-21. Epub 2010 Apr 9.

Doumatey AP et al. Relationships among obesity, inflammation, and insulin resistance in African Americans and West Africans. Obesity (Silver Spring). 2010 Mar; 18(3):598-603. Epub 2009 Oct

Other Publications:

Gurdasani D, Carstensen T, Tekola-Ayele F---- Doumatey AP et al. The African Genome Variation Project shapes medical genetics in Africa. Nature. 2014 Dec 3. doi: 10.1038/nature13997. [Epub ahead of print]

Ng MC,...., Doumatey A, et al. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet. 2014 Aug 7; 10(8):e1004517.eCollection 2014 Aug. (Collaborative study with several consortia including one of CRGGH, Howard University Family Study, HUFS )

Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J. Evolution of the primate trypanolytic factor APOL1. Proc Natl Acad Sci U S A. 2014 May 20; 111(20).Epub 2014 May 7

Shriner D, Herbert A, Doumatey AP, Zhou J, Huang H, Erdos MR, Chen G, Gerry NP, Christman MF, Adeyemo A, Rotimi CN. Multiple loci associated with renal function in African Americans. PLoS One. 2012; 7(9): Epub 2012 Sep 13.

Adeyemo A, Bentley AR, Meilleur KG, Doumatey AP, Chen G, Zhou J, Shriner D, Huang H, Herbert A, Gerry NP, Christman MF, Rotimi CN. Transferability and Fine Mapping of genome-wide associated loci for lipids in African Americans. BMC Med Genet. 2012 Sep 21; 13(1):88. [Epub ahead of print]

Bentley AR, Doumatey AP, Chen G, Huang H, Zhou J, Shriner D, Jiang C, Zhang Z, Liu G, Fasanmade O, Johnson T, Oli J, Okafor G, Eghan BA Jr, Agyenim-Boateng K, Adeleye J, Balogun W, Adebamowo C, Amoah A, Acheampong J, Adeyemo A, Rotimi CN. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association.Int J Nephrol. 2012; 2012: 748984. Epub 2012 Sep 2.

Chen G, Ramos E, Adeyemo A, Shriner D, Zhou J, Doumatey AP, Huang H, Erdos MR, Gerry NP, Herbert A, Bentley AR, Xu H, Charles BA, Christman MF, Rotimi CN. UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur J Hum Genet. 2012 Apr; 20(4):463-8. Epub 2011 Nov 16.

Chambers JC,..., Doumatey A et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 2011 Oct 16;43(11):1131-8 (Collaborative study with several consortia including one of CRGGH’s cohort, HUFS)

Faruque MU, Chen G, Doumatey A, Huang H, Zhou J, Dunston GM, Rotimi CN, Adeyemo AA.Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans. J Hypertens. 2011 Oct; 29(10):1906-12.

Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR,Doumatey AP et al. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.Hum Mol Genet. 2011 Jun 1; 20(11):2273-84. Epub 2011 Mar 4.

Charles BA, Shriner D, Doumatey A, Chen G, Zhou J, Huang H, Herbert A, Gerry NP, Christman MF, Adeyemo A, Rotimi CN. A genome-wide association study of serum uric acid in African Americans. BMC Med Genomics. 2011 Feb 4; 4:17.

Ramos E, Chen G, Shriner D, Doumatey A, Gerry NP, Herbert A, Huang H, Zhou J, Christman MF, Adeyemo A, Rotimi C. Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans. Diabetologia. 2011 Apr; 54(4):783-8. Epub 2010 Dec 25.

Sumner AE, Zhou J, Doumatey A, Imoisili OE, Amoah A, Acheampong J, Oli J, Johnson T, Adebamowo C, Rotimi CN. Low HDL-Cholesterol with Normal Triglyceride Levels is the Most Common Lipid Pattern in West Africans and African Americans with Metabolic Syndrome: Implications for Cardiovascular Disease Prevention. CVD Prev Control. 2010 Sep 1;5(3):75-80.

Chen G, Shriner D, Zhou J, Doumatey A, Huang H, Gerry NP, Herbert A, Christman MF, Chen Y, Dunston GM, Faruque MU, Rotimi CN, Adeyemo A. Development of admixture mapping panels for African Americans from commercial high-density SNP arrays. BMC Genomics. 2010 Jul 5; 11:417

Adeyemo A, Chen G, Zhou J, Shriner D, Doumatey A, Huang H, Rotimi C. FTO genetic variation and association with obesity in West Africans and African Americans. Diabetes. 2010 Jun; 59(6):1549-54. Epub 2010 Mar 18

Last updated: April 17, 2017