Ian C. Nova, Ph.D.
Division of Genome Sciences
B.S. Santa Clara University, 2012
Ph.D. University of Washington, 2020
Dr. Ian Nova joined the National Human Genome Research Institute’s Extramural Research Program as a program director in 2023. He manages a portfolio of grants in genomic technology development, focusing on novel tools for nucleic acid sequencing. He is also the program manager for the NHGRI Small Business Program, which awards grants to early-stage small businesses that fit NHGRI’s mission and vision.
Prior to joining NHGRI, Dr. Nova was a postdoctoral researcher in the Department of Bionanoscience at Delft University of Technology, where he developed new technologies for protein sequencing. He also worked as an academic researcher at the University of Washington, designing nanopore-based technologies for nucleic acid sequencing and single-molecule enzymology.
Dr. Nova received a B.S. in bioengineering from Santa Clara University and a Ph.D. in molecular engineering and sciences from the University of Washington. He completed a postdoctoral research fellowship at the Kavli Institute of Nanoscience Delft at Delft University of Technology.
Laszlo AH, Craig JM, Gavrilov M, Tippana R, Nova IC, Huang JR, Kim HC, Abell SJ, deCampos-Stairiker M, Mount JW, Bowman JL, Baker KS, Higinbotham H, Bobrovnikov D, Ha T, Gundlach JH. Sequence-dependent mechanochemical coupling of helicase translocation and unwinding at single-nucleotide resolution. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2202489119. doi: 10.1073/pnas.2202489119. Epub 2022 Aug 29.
Craig JM, Laszlo AH, Nova IC, Gundlach JH. Modelling single-molecule kinetics of helicase translocation using high-resolution nanopore tweezers (SPRNT). Essays Biochem. 2021 Apr 16;65(1):109-127. doi: 10.1042/EBC20200027.
Craig JM, Laszlo AH, Nova IC, Brinkerhoff H, Noakes MT, Baker KS, Bowman JL, Higinbotham HR, Mount JW, Gundlach JH. Determining the effects of DNA sequence on Hel308 helicase translocation along single-stranded DNA using nanopore tweezers. Nucleic Acids Res. 2019 Mar 18;47(5):2506-2513. doi: 10.1093/nar/gkz004.
Craig JM, Laszlo AH, Brinkerhoff H, Derrington IM, Noakes MT, Nova IC, Tickman BI, Doering K, de Leeuw NF, Gundlach JH. Revealing dynamics of helicase translocation on single-stranded DNA using high-resolution nanopore tweezers. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11932-11937. doi: 10.1073/pnas.1711282114. Epub 2017 Oct 16.
Nova IC, Derrington IM, Craig JM, Noakes MT, Tickman BI, Doering K, Higinbotham H, Laszlo AH, Gundlach JH. Investigating asymmetric salt profiles for nanopore DNA sequencing with biological porin MspA. PLoS One. 2017 Jul 27;12(7):e0181599. doi: 10.1371/journal.pone.0181599.
Derrington IM, Craig JM, Stava E, Laszlo AH, Ross BC, Brinkerhoff H, Nova IC, Doering K, Tickman BI, Ronaghi M, Mandell JG, Gunderson KL, Gundlach JH. Subangstrom single-molecule measurements of motor proteins using a nanopore. Nat Biotechnol. 2015 Oct;33(10):1073-5. doi: 10.1038/nbt.3357. Epub 2015 Sep 28.
Morton D, Mortezaei S, Yemenicioglu S, Isaacman MJ, Nova IC, Gundlach JH, Theogarajan L. Tailored Polymeric Membranes for Mycobacterium Smegmatis Porin A (MspA) Based Biosensors. J Mater Chem B. 2015 Jul 7;3(25):5080-5086. doi: 10.1039/C5TB00383K.
Craig JM, Laszlo AH, Derrington IM, Ross BC, Brinkerhoff H, Nova IC, Doering K, Tickman BI, Svet MT, Gundlach JH. Direct Detection of Unnatural DNA Nucleotides dNaM and d5SICS using the MspA Nanopore. PLoS One. 2015 Nov 20;10(11):e0143253. doi: 10.1371/journal.pone.0143253.
Laszlo AH, Derrington IM, Ross BC, Brinkerhoff H, Adey A, Nova IC, Craig JM, Langford KW, Samson JM, Daza R, Doering K, Shendure J, Gundlach JH. Decoding long nanopore sequencing reads of natural DNA. Nat Biotechnol. 2014 Aug;32(8):829-33. doi: 10.1038/nbt.2950. Epub 2014 Jun 25.
Laszlo AH, Derrington IM, Brinkerhoff H, Langford KW, Nova IC, Samson JM, Bartlett JJ, Pavlenok M, Gundlach JH. Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18904-9. doi: 10.1073/pnas.1310240110. Epub 2013 Oct 28.
Last updated: June 27, 2023