Genome Technology Program

The Genome Technology Program is refining current technologies to increase efficiency and decrease cost while maintaining or improving data quality, and developing completely novel approaches to achieve orders-of-magnitude improvement.

Overview

The Genome Technology program supports research to develop new methods, technologies and instruments that enable rapid, low-cost determination of DNA sequence, SNP genotyping (with the Genetic Variation Program) and functional genomics (broadly defined) experiments (with the Functional Analysis Program).

The program also supports and coordinates transfer of technology from developers to users, and promotes collaborative, multidisciplinary programs that closely integrate research projects at academic and industrial laboratories.

The National Human Genome Research Institute (NHGRI) has participated in numerous trans-NIH efforts, including one on bioengineering research. The development of integrated concepts and tools for genomic research benefits from bioengineering research, methods and approaches. NHGRI supports bioengineering research through grants made in response to NHGRI program announcements and requests for application, and through NHGRI participation in trans-NIH bioengineering program announcements, such as the Bioengineering Research Grants (BRG) program and other Funding Opportunities that are listed below.

Advanced Sequencing Technology Awards

In 2004, NHGRI initiated a coordinated effort to support the development of technologies to dramatically reduce the cost of DNA sequencing, a move aimed at broadening the applications of genomic information in medical research and health care.

Resources

Genome Technology News

Genome Technology Program Bibliography: Publications and Patents

NHGRI launched an ambitious program in 2004 to reduce the cost of full mammalian genome sequencing initially by 100-fold and subsequently by an additional 100-fold, aiming ultimately at about $1,000. Below, listed by Principal Investigator, are citations and links to many of the articles and patents resulting from this program and closely related research.

Genome Technology Program Publications and Patents

Genome Technology Program Related Information

Genome Technology Program Reports

Genome Technology Program Policies

Funding Opportunities

Nucleic Acid Sequencing

  • PAR-18-779 Novel Genomic Technology Development (R43/R44 Clinical Trial Not Allowed)
    Expiration Date: Jan 08, 2021

    • NOT-HG-19-006 Reinstatement of NIH SBIR Direct-to-Phase II Authority and Associated Updates to NHGRI Associated SBIR FOAs

  • RFA-HG-18-003 Novel Nucleic Acid Sequencing Technology Development (R43/R44 Clinical Trial Not Allowed)
    Expiration Date: Sep 11, 2020

    • NOT-HG-19-006 Reinstatement of NIH SBIR Direct-to-Phase II Authority and Associated Updates to NHGRI Associated SBIR FOAs

    • NOT-HG-19-011 Notice of Change: Emphasizing Opportunity for Developing Comprehensive Human Genome Sequencing Methodologies in Response to NHGRI Novel Nucleic Acid Sequencing Technology Development FOAs

Genomic Technology Development

  • PAR-16-015 Novel Genomic Technology Development (R21) (Expired)
    Expiration Date: Jan 12, 2018

  • PAR-16-017 Novel Genomic Technology Development Direct to Phase II SBIR (R44) (Expired)
    Expiration Date: Jan 12, 2017

    • NOT-HG-16-009 Notice Clarifying Eligibility Criteria for PAR-16-017 "Novel Genomic Technology Development - Direct to Phase II SBIR Grant (R44)"

Program Staff

Michael W. Smith, Ph.D.
Mike Smith, Ph.D.
  • Program Director Genome Technology Program
  • Division of Genome Sciences