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Genome Technology Program

The Genome Technology Program is refining current technologies to increase efficiency and decrease cost while maintaining or improving data quality, and developing completely novel approaches to achieve orders-of-magnitude improvement.

Overview

The Genome Technology program at NHGRI supports research to develop new methods, technologies and instruments that enable rapid, low-cost determination of nucleic acid sequence and genotyping along with epigenetic, functional and synthetic genomics experiments. The development of completely novel approaches and achieving orders-of-magnitude improvements in genomic technologies are foundational efforts of the program. The refinement of current technologies to increase efficiency and decrease cost while maintaining or improving data quality and the integration of process steps is key to achieving these goals.

The program also supports and coordinates technology transfer from developers to users, and promotes collaborative, multidisciplinary programs that closely integrate research projects in academic and industrial laboratories.

  • Overview

    The Genome Technology program at NHGRI supports research to develop new methods, technologies and instruments that enable rapid, low-cost determination of nucleic acid sequence and genotyping along with epigenetic, functional and synthetic genomics experiments. The development of completely novel approaches and achieving orders-of-magnitude improvements in genomic technologies are foundational efforts of the program. The refinement of current technologies to increase efficiency and decrease cost while maintaining or improving data quality and the integration of process steps is key to achieving these goals.

    The program also supports and coordinates technology transfer from developers to users, and promotes collaborative, multidisciplinary programs that closely integrate research projects in academic and industrial laboratories.

Resources

Genome Technology Program Bibliography: Publications and Patents

NHGRI launched an ambitious program in 2004 to reduce the cost of full mammalian genome sequencing initially by 100-fold and subsequently by an additional 100-fold, aiming ultimately at about $1,000. Below, listed by Principal Investigator, are citations and links to many of the articles and patents resulting from this program and closely related research.

Genome Technology Program Publications and Patents

Genome Technology Program Related Information

Genome Technology Program Reports

Genome Technology Program Policies

Advanced Sequencing Technology Awards

In 2004, NHGRI initiated a coordinated effort to support the development of technologies to dramatically reduce the cost of DNA sequencing, a move aimed at broadening the applications of genomic information in medical research and health care.

News

Genome Technology News

Events

Active Funding Opportunities

Nucleic Acid Sequencing

  • RFA-HG-20-014 Novel Synthetic Nucleic Acid Technology Development (R01 Clinical Trial not allowed)
    Expiration Date: Jun 25, 2022

  • RFA-HG-20-015 Novel Synthetic Nucleic Acid Technology Development (R21 Clinical Trial not allowed)
    Expiration Date: Jun 25, 2022

  • RFA-HG-20-016 Novel Synthetic Nucleic Acid Technology Development (R43/R44)( Clinical Trial not allowed)
    Expiration Date: Jun 25, 2022

  • RFA-HG-18-001 Novel Nucleic Acid Sequencing Technology Development (R01 Clinical Trial Not Allowed)
    Expiration Date: Sep 11, 2020

    • NOT-HG-19-011 Notice of Change: Emphasizing Opportunity for Developing Comprehensive Human Genome Sequencing Methodologies in Response to NHGRI Novel Nucleic Acid Sequencing Technology Development FOAs

  • RFA-HG-18-002 Novel Nucleic Acid Sequencing Technology Development (R21 Clinical Trial Not Allowed)
    Expiration Date: Sep 11, 2020

    • NOT-HG-19-011 Notice of Change: Emphasizing Opportunity for Developing Comprehensive Human Genome Sequencing Methodologies in Response to NHGRI Novel Nucleic Acid Sequencing Technology Development FOAs

  • RFA-HG-18-003 Novel Nucleic Acid Sequencing Technology Development (R43/R44 Clinical Trial Not Allowed)
    Expiration Date: Sep 11, 2020

    • NOT-HG-19-006 Reinstatement of NIH SBIR Direct-to-Phase II Authority and Associated Updates to NHGRI Associated SBIR FOAs

    • NOT-HG-19-011 Notice of Change: Emphasizing Opportunity for Developing Comprehensive Human Genome Sequencing Methodologies in Response to NHGRI Novel Nucleic Acid Sequencing Technology Development FOAs

Genomic Technology Development

  • RFA-HG-20-019 NHGRI Technology Development Coordinating Center (U24 Clinical Trial Not Allowed)
    Expiration Date: Jun 25, 2020

  • PAR-18-777 Novel Genomic Technology Development (R01 Clinical Trial Not Allowed)
    Expiration Date: Jan 08, 2021

  • PAR-18-778 Novel Genomic Technology Development (R21 Clinical Trial Not Allowed)
    Expiration Date: Jan 08, 2021

  • PAR-18-779 Novel Genomic Technology Development (R43/R44 Clinical Trial Not Allowed)
    Expiration Date: Jan 08, 2021

    • NOT-HG-19-006 Reinstatement of NIH SBIR Direct-to-Phase II Authority and Associated Updates to NHGRI Associated SBIR FOAs

Expired Funding Opportunities

Genomic Technology Development

Program Staff

Mike Smith
Mike Smith, Ph.D.
  • Program Director Genome Technology Program
  • Division of Genome Sciences
Stephanie Morris
Stephanie A. Morris, Ph.D.
  • Program Director
  • Division of Genome Sciences

Last updated: April 1, 2020