Genome Technology Program

The Genome Technology program at NHGRI supports research to develop new methods, technologies and instruments that enable rapid, low-cost determination of nucleic acid sequence and genotyping along with epigenetic, functional and synthetic genomics experiments. The development of completely novel approaches and achieving orders-of-magnitude improvements in genomic technologies are foundational efforts of the program. The refinement of current technologies to increase efficiency and decrease cost while maintaining or improving data quality and the integration of process steps is key to achieving these goals.

The program also supports and coordinates technology transfer from developers to users, and promotes collaborative, multidisciplinary programs that closely integrate research projects in academic and industrial laboratories.

Genome Technology Program Bibliography: Publications and Patents

NHGRI launched an ambitious program in 2004 to reduce the cost of full mammalian genome sequencing initially by 100-fold and subsequently by an additional 100-fold, aiming ultimately at about $1,000. Below, listed by Principal Investigator, are citations and links to many of the articles and patents resulting from this program and closely related research.

Genome Technology Program Publications and Patents

Genome Technology Program Related Information

• Concept Clearance: Technology Development (RFAs)
  September 16, 2019 Council
   
• Concept Clearance: Technology Development (RFAs)
  September 16, 2019 Council
   
• Concept Clearance: Novel Nucleic Acid Sequencing Technology Development
  February 12, 2018 Council
   
• Workshop Report, "Genomic Technology Development"
  May 18, 2015 Council: Concept Clearance
   
• Concept Presentation, "Genomic Technology Development"
  May 18, 2015 Council: Concept Clearance
   
• Concept Papers for Two DNA Sequencing Technology Development Programs
  May 19, 2003 Council

Genome Technology Program Reports

• Sequencing and Re-Sequencing the Biome! July 2002
• Sequencing Technology Workshop May 13, 1998
• Sequencing Variation Workshop March 31-April 1, 1997
• Functional Analysis Workshop December 2-3, 1997

Genome Technology Program Policies

• Principles and Guidelines for Recipients of NIH Research Grants and Contracts on Obtaining and Disseminating Biomedical Research Resources: Final Notice [grants.nih.gov]

RFAs

• RFA-HG-20-014: Novel Synthetic Nucleic Acid Technology Development (R01 Clinical Trial not allowed)
• RFA-HG-20-015: Novel Synthetic Nucleic Acid Technology Development (R21) (Clinical Trial not allowed)
• RFA-HG-20-016: Novel Synthetic Nucleic Acid Technology Development (R43/R44) (Clinical Trial Not Allowed)
• RFA-HG-21-001: Technology Development for Single-Molecule Protein Sequencing and Single-Cell Proteome Analysis (R01 Clinical Trial not allowed)
• RFA-HG-21-002: Technology Development for Single-Molecule Protein Sequencing (R21 Clinical Trial not allowed)
• RFA-HG-21-006: Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R01 Clinical Trial not Allowed)
• RFA-HG-21-007: Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R21 Clinical Trial not Allowed)
• RFA-HG-21-008: Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R43/R44 Clinical Trial not Allowed)
   

PAR

• PAR-21-247: Technology Development for Single-Molecule Protein Sequencing (R43/R44 Clinical Trial Not Allowed)
   

Notice of Special Interest (NOSI)

• NOT-HG-21-018: Advancing Genomic Technology Development for Research and Clinical Application

RFAs

• RFA-HG-20-019: NHGRI Technology Development Coordinating Center (U24 Clinical Trial Not Allowed)
• RFA-HG-18-001: Novel Nucleic Acid Sequencing Technology Development (R01 Clinical Trial Not Allowed)
• RFA-HG-18-002: Novel Nucleic Acid Sequencing Technology Development (R21 Clinical Trial Not Allowed)
• RFA-HG-18-003: Novel Nucleic Acid Sequencing Technology Development (R43/R44 Clinical Trial Not Allowed)
   

PARs

• PAR-18-777: Novel Genomic Technology Development (R01 Clinical Trial Not Allowed)
• PAR-18-778: Novel Genomic Technology Development (R21 Clinical Trial Not Allowed)
• PAR-18-779: Novel Genomic Technology Development (R43/R44 Clinical Trial Not Allowed)

In 2004, NHGRI initiated a coordinated effort to support the development of technologies to dramatically reduce the cost of DNA sequencing, a move aimed at broadening the applications of genomic information in medical research and health care.

• Advanced Sequencing Technology Awards 2014
  August 1, 2014 News Release: NIH awards $14.5 million to research groups studying newest DNA sequencing techniques
   
• Advanced Sequencing Technology Awards 2013
  September 6, 2013 News Release: New NIH awards focus on nanopore technology for DNA sequencing
   
• Advanced Sequencing Technology Awards 2012
  September 14, 2012 News Release: New NIH/NHGRI grants to harness nanoscale technologies to cut DNA sequencing costs
   
• Advanced Sequencing Technology Awards 2011
  August 22, 2011 News Release: NHGRI funds development of revolutionary DNA sequencing technologies
   
• Advanced Sequencing Technology Awards 2010
  September 13, 2010 News Release: NHGRI funds development of third generation DNA sequencing technologies
   
• Advanced Sequencing Technology Awards 2009
  October 8, 2009 Online News Feature: NHGRI Uses Recovery Act Funds to Accelerate Genome Research to Improve Human Health
   
• Advanced Sequencing Technology Awards 2008
  August 20, 2008 News Release: NHGRI Seeks DNA Sequencing Technologies Fit for Routine Laboratory and Medical Use
   
• Advanced Sequencing Technology Awards 2007
  August 1, 2007 News Release: New Grants Bolster Efforts to Generate Faster and Cheaper Tools for DNA Sequencing
   
• October 4, 2006 News Release: NHGRI Aims to Make DNA Sequencing Faster, More Cost Effective
   
• Advanced Sequencing Technology Awards 2005
  August 8, 2005 Release: NHGRI Expands Effort to Revolutionize Sequencing Technologies
   
• Advanced Sequencing Technology Awards 2004
  October 14, 2004 Release: NHGRI Seeks Next Generation of Sequencing Technologies

Genome Technology News

• Nanopore DNA sequencing: New approaches to an old challenge (December 2013)
• Genome Advance of the Month - Proteus: Discovering the tiniest disease-causing flaws - and improving sequencing technologies (July 2011)
• The Road to the $1000 Genome Via Nanopores - A Roundup of Sequencing Technology Developments (February 7, 2011)
• The Road to the $1000 Genome - A Roundup of Sequencing Technology Developments (August 2, 2010)

• 2021 Advanced Genomic Technology Development Meeting
  May 25-27, 2021
   
• 2020 Advanced Genomic Technology Development Meeting
  May 27-29, 2020
   
• NHGRI at the AGBT 2020 Meeting
  February 23-26, 2020
   
  • Resources for New and Early Stage Genomics Investigators
     
• 2019 Advanced Genomic Technology Development Meeting
  May 29-31, 2019
   
• 2018 Advanced Genomic Technology Development Meeting
  May 30 - June 1, 2018
   
• 2017 Advanced Genomic Technology Development Meeting
  May 22-25, 2017