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Program Director Human Heredity and Health in Africa

Division of Genome Sciences

Education

B.A. Earlham College, 1990

Ph.D. University of Connecticut, 2000

Biography

Dr. Jennifer L. Troyer joined the National Human Genome Research Institute as a program director in 2013. Her main responsibility is as part of the team administering Human Health and Heredity in Africa (H3Africa), a Common Fund (trans-NIH) initiative that facilitates applying contemporary research approaches to the study of genomics and environmental determinants of common diseases with the goal of improving the health of African populations.

Dr. Troyer earned a B.A. in Biology from Earlham College, a Ph.D. in Genetics from the University of Connecticut, and was a postdoctoral fellow at the National Cancer Institute and Colorado State University. She started her career in classical and molecular genetics using Drosophila as a model organism to study the phenomenon of concerted evolution. She then moved on to lentiviruses and became interested in viral and host interactions. Her research has ranged from cats to lions to humans, but primarily focused on genetic variations in the virus and host that alter the outcome of infection. She has experience in leading Genome Wide Association Studies and has participated in international consortium efforts to identify host restriction factors for HIV/AIDS.

More recently, Dr. Troyer was in charge of technology development and genomics research in a core service lab at the National Cancer Institute, where she gained experience in next generation and single-molecule sequencing and cancer genomics.

Publications

Tang M, Lautenberger JA, Gao X, Sezgin E, Hendrickson SL, Troyer JL, David VA, Guan L, McIntosh CE, Guo X, Zheng Y, Liao J, Deng H, Malasky M, Kessing B, Winkler CA, Carrington M, Dé The G, Zeng Y, O'Brien. The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition groove. SJ.PLoS Genet. 2012;8(11):e1003103. doi: 10.1371/journal.pgen.1003103. Epub 2012 Nov 29. [PubMed]

An P, Li R, Wang JM, Yoshimura T, Takahashi M, Samudralal R, O'Brien SJ, Phair J, Goedert JJ, Kirk GD, Troyer JL, Sezgin E, Buchbinder SP, Donfield S, Nelson GW, Winkler CA. Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia. PLoS Genet, Oct;7(10). 2011. [PubMed]

Troyer JL, Nelson GW, Lautenberger JA, Chinn L, McIntosh C, Johnson RC, Sezgin E, Kessing B, Malasky M, Hendrickson SL, Li G, Pontius J, Tang M, An P, Winkler CA, Limou S, Le Clerc S, Delaneau O, Zagury JF, Schuitemaker H, van Manen D, Bream JH, Gomperts ED, Buchbinder S, Goedert JJ, Kirk GD, O'Brien SJ. Genome-wide association study implicates PARD3B-based AIDS restriction. J Infect Dis. May 15;203(10):1491-502. 2011. [PubMed]

Sezgin E, Jabs DA, Hendrickson SL, Van Natta M, Zdanov A, Lewis RA, Smith MW, Troyer JL, O'Brien SJ; SOCA Research Group. Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS. J Infect Dis, 202(4):606-13. [PubMed]

Sezgin E, Drosdak A, McIntosh C, Kessing B, Lautenberger JA, Goedert JJ, Phair JP, Troyer JL, Smith MW, O'Brien SJ. Examination of disease-based selection, demographic history and population structure in European Y-chromosome haplogroup I. J Hum Genet. 55(9):613-20. 2010. [PubMed

Brown MA, Troyer JL, Pecon-Slattery J, Roelke ME, O'Brien SJ. Genetics and pathogenesis of feline infectious peritonitis virus. Emerg Infect Dis, 15(9):1445-52. 2009. [PubMed]

Antunes A, Troyer JL, Roelke ME, Pecon-Slattery J, Packer C, Winterbach C, Winterbach H, Hemson G, Frank L, Stander P, Siefert L, Driciru M, Funston PJ, Alexander KA, Prager KC, Mills G, Wildt D, Bush M, O'Brien SJ, Johnson WE. The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics. PLoS Gen, 4(11):e1000251. 2008. [PubMed]

Terwee JA, Carlson JK, Sprague WS, Sondgeroth KS, Shropshire SB, Troyer JL, VandeWoude S. Prevention of immunodeficiency virus induced CD4+ T-cell depletion by prior infection with a non-pathogenic virus. Virology, 20;377(1):63-70. 2008. [PubMed]

Troyer JL, Vandewoude S, Pecon-Slattery J, McIntosh C, Franklin S, Antunes A, Johnson W, O'Brien SJ. FIV cross-species transmission: an evolutionary prospective. Vet Immunol Immunopathol, 123(1-2):159-66. 2008. [PubMed]

Brown MA, Cunningham MW, Roca AL, Troyer JL, Johnson WE, O'Brien SJ. Genetic characterization of feline leukemia virus from Florida panthers. Emerg Infect Dis, 14(2):252-9. 2008. [PubMed]

Franklin SP, Troyer JL, Terwee JA, Lyren LM, Boyce WM, Riley SP, Roelke ME, Crooks KR, Vandewoude S. Frequent transmission of immunodeficiency viruses among bobcats and pumas. J Virol, 81(20):10961-9. 2007. [PubMed]

Smirnova N, Troyer JL, Schissler J, Terwee J, Poss M, VandeWoude S. Feline lentiviruses demonstrate differences in receptor repertoire and envelope structural elements. Virology, 342(1):60-76. 2005. [PubMed]

Troyer JL, Pecon-Slattery J, Roelke ME, Johnson W, VandeWoude S, Vazquez-Salat N, Brown M, Frank L, Woodroffe R, Winterbach C, Winterbach H, Hemson G, Bush M, Alexander KA, Revilla E, O'Brien SJ. Seroprevalence and genomic divergence of circulating strains of feline immunodeficiency virus among Felidae and Hyaenidae species. J Virol, 79(13):8282-94. 2005. [PubMed]

Pearks Wilkerson AJ, Teeling EC, Troyer JL, Bar-Gal GK, Roelke M, Marker L, Pecon-Slattery J, O'Brien SJ. Coronavirus outbreak in cheetahs: lessons for SARS. Curr Biol, 23;14(6):R227-8. 2004. [PubMed]

Troyer JL, Pecon-Slattery J, Roelke ME, Black L, Packer C, O'Brien SJ. Patterns of feline immunodeficiency virus multiple infection and genome divergence in a free-ranging population of African lions. J Virol. 78(7):3777-91. 2004. {PubMed]

Last updated: March 27, 2014