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Developmental Genotype-Tissue Expression (dGTEx)

The goal of the dGTEx initiative is to establish a resource database and associated tissue bank to study gene expression patterns in multiple reference tissues during human developmental stages, building upon the completed Genotype-Tissue Expression (GTEx) project.

The National Human Genome Research Institute (NHGRI), the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD), the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) are collaborating on a new initiative, developmental Genotype-Tissue Expression (dGTEx), to catalog and analyze transcriptional profiles from a wide variety of tissues from the pediatric period, including neonates through adolescents, in a post-mortem setting. 


Studying gene expression during the pediatric period will fill key gaps in our understanding of the role of gene expression in normal human development. It will provide insight into disease processes that originate before maturation is complete and potentially into how developmental gene expression patterns affect important clinical factors such as drug response in early and late childhood. It will also provide a baseline for comparing gene expression and regulatory patterns during normal development with such patterns in individuals with disease.

Please refer to the links below to find more information about the concept and discussion during NHGRI’s February 2020 Council.

Funding Opportunities


RFA-HG-23-005Data Integration and Statistical Analysis Methods (DISAM) (U01 Clinical Trial Not Allowed)
Application Due Date: November 20, 2023
Expiration Date: November 21, 2023


Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed)
Application Due Date(s): December 3, 2020
Expiration Date: December 4, 2020

Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Genotype-Tissue Expression Project (U24 Clinical Trial Not Allowed)
Application Due Date(s): November 13, 2020
Expiration Date: November 14, 2020


dGTEx Locations

dGTEx BCP and LDACC locations map




Award Number

Biospecimen Procurement Center (BPC)

Children’s Hospital of Philadelphia

Philadelphia, PA


Children’s National Medical Center

Washington, DC

Cincinnati Children’s Hospital Medical Center

Cincinnati, OH

Johns Hopkins All Children’s Hospital

St. Petersburg, FL

National Disease Research Interchange

Philadelphia, PA

University of Maryland Brain and Tissue Bank

Baltimore, MD

University of Rochester Medical Center

Rochester, NY

Dell Children’s Medical Center at University of Texas, Austin

Austin, TX

University of Mississippi Medical Center

Jackson, MS

University of Louisville School of Medicine – Norton Children’s Hospital

Louisville, KY

Nicklaus Children’s Hospital

Miami, FL

Laboratory, Data Analysis, and Coordinating Center (LDACC)

New York Genome Center

New York, NY


Massachusetts General Hospital

Boston, MA

Broad Institute

Cambridge, MA

Stanford University

Stanford, CA

Harvard Medical School

Boston, MA

Yale University

New Haven, CT


Baylor College of Medicine

Houston, TX

Multispecies Non-Human Primate Research Center

Oregon Health & Science University

Portland, OR


Massachusetts Institute of Technology

Cambridge, MA

Broad Institute

Cambridge, MA

Yale University

New Haven, CT


Program Directors

Jyoti Dayal
Jyoti G. Dayal, M.S.
  • Program Director
  • Division of Genomic Medicine
Alexander Arguello
Alexander Arguello, Ph.D.
  • Program Director
  • Division of Genome Sciences
John Ilekis
John Ilekis, Ph.D.
  • Program Director
  • Pregnancy and Perinatology Branch, NICHD

Scientific Program Analysts

Jake Baroch
Jake Baroch, B.S.
  • Scientific Program Analyst
  • Division of Genome Sciences

Last updated: April 19, 2023