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Developmental Genotype-Tissue Expression (dGTEx)

The goal of the dGTEx initiative is to establish a resource database and associated tissue bank to study gene expression patterns in multiple reference tissues during human developmental stages, building upon the completed Genotype-Tissue Expression (GTEx) project.

The National Human Genome Research Institute (NHGRI), the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD), the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) are collaborating on a new initiative, developmental Genotype-Tissue Expression (dGTEx), to catalog and analyze transcriptional profiles from a wide variety of tissues from the pediatric period, including neonates through adolescents, in a post-mortem setting. 

Overview

Studying gene expression during the pediatric period will fill key gaps in our understanding of the role of gene expression in normal human development. It will provide insight into disease processes that originate before maturation is complete and potentially into how developmental gene expression patterns affect important clinical factors such as drug response in early and late childhood. It will also provide a baseline for comparing gene expression and regulatory patterns during normal development with such patterns in individuals with disease.

Please refer to the links below to find more information about the concept and discussion during NHGRI’s February 2020 Council.

Funding Opportunities

Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed)
RFA-HD-21-008
Application Due Date(s): December 3, 2020
Expiration Date: December 4, 2020

Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Genotype-Tissue Expression Project (U24 Clinical Trial Not Allowed)
RFA-HG-20-039
Application Due Date(s): November 13, 2020
Expiration Date: November 14, 2020

Events

dGTEx Locations

 

An infographic of dGTEx locations that include biospecimen procurement centers (BPC) and laboratory, data analysis and coordinating centers (LDACC)

 

The Biospecimen Procurement Centers (BPC) are:

  • Children's Hospital of Philadelphia, Philadelphia, PA
  • Children's National Medical Center, Washington, DC
  • Cincinnati Children's Hospital Medical Center, Cincinnati, OH
  • Johns Hopkins All Children's Hospital, St. Petersburg, FL
  • National Disease Research Interchange, Philadelphia, PA
  • University of Maryland Brain and Tissue Bank, Baltimore, MD
  • University of Rochester Medical Center Rochester, NY
  • Dell Children's Medical Center at University of Texas, Austin, Austin, TX
  • University of Mississippi Medical Center, Jackson, MS
  • University of Louisville School of Medicine - Norton Children's Hospital, Louisville, KY
  • Nicklaus Children's Hospital, Miami, FL

The Laboratory, Data Analysis and Coordinating Centers (LDACC) are:

  • New York Genome Center New York, NY
  • Massachusetts General Hospital Boston, MA
  • Broad Institute, Inc. Cambridge, MA
  • Stanford University Stanford, CA
  • Harvard Medical School / Harvard University, Boston, MA
  • Yale University New Haven, CT
  • Baylor College of Medicine Houston, TX

Contacts

Program Directors

Jyoti Dayal, M.S.
Jyoti G. Dayal, M.S.
  • Program Director
  • Division of Genomic Medicine
Alexander Arguello
Alexander Arguello, Ph.D.
  • Program Director
  • Division of Genome Sciences
Generic Profile Photo
John Ilekis, Ph.D.
  • Program Director, Maternal & Fetal Molecular Biology and Genetics
  • Pregnancy and Perinatology Branch, National Institute of Child Health and Human Development

Scientific Program Analysts

Allie Osgood
Allie Osgood
  • Scientific Program Analyst
  • Division of Genome Sciences

Last updated: May 12, 2022