Developmental Genotype-Tissue Expression (dGTEx)

The goal of the dGTEx initiative is to establish a resource database and associated tissue bank to study gene expression patterns in multiple reference tissues during human developmental stages, building upon the completed Genotype-Tissue Expression (GTEx) project.

The National Human Genome Research Institute (NHGRI), the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD), the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) are collaborating on a new initiative, developmental Genotype-Tissue Expression (dGTEx), to catalog and analyze transcriptional profiles from a wide variety of tissues from the pediatric period, including neonates through adolescents, in a post-mortem setting.

Overview

Studying gene expression during the pediatric period will fill key gaps in our understanding of the role of gene expression in normal human development. It will provide insight into disease processes that originate before maturation is complete and potentially into how developmental gene expression patterns affect important clinical factors such as drug response in early and late childhood. It will also provide a baseline for comparing gene expression and regulatory patterns during normal development with such patterns in individuals with disease.

Please refer to the links below to find more information about the concept and discussion during NHGRI’s February 2020 Council.

Funding Opportunities

Active

RFA-HG-23-005: Data Integration and Statistical Analysis Methods (DISAM) (U01 Clinical Trial Not Allowed)
Application Due Date: November 20, 2023
Expiration Date: November 21, 2023

Expired

Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed)
RFA-HD-21-008
Application Due Date(s): December 3, 2020
Expiration Date: December 4, 2020

Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Genotype-Tissue Expression Project (U24 Clinical Trial Not Allowed)
RFA-HG-20-039
Application Due Date(s): November 13, 2020
Expiration Date: November 14, 2020

News

NIH will expand existing gene expression resources to include developmental tissues
October 5, 2021

Events

NHGRI and NICHD dGTEx Applicant Webinar
August 3, 2020, 1:30 - 3:00 p.m. Eastern

dGTEx Locations

dGTEx BCP and LDACC locations map

Institution	Location	Award Number
Biospecimen Procurement Center (BPC)
Children’s Hospital of Philadelphia	Philadelphia, PA	HD106537
Children’s National Medical Center	Washington, DC
Cincinnati Children’s Hospital Medical Center	Cincinnati, OH
Johns Hopkins All Children’s Hospital	St. Petersburg, FL
National Disease Research Interchange	Philadelphia, PA
University of Maryland Brain and Tissue Bank	Baltimore, MD
University of Rochester Medical Center	Rochester, NY
Dell Children’s Medical Center at University of Texas, Austin	Austin, TX
University of Mississippi Medical Center	Jackson, MS
University of Louisville School of Medicine – Norton Children’s Hospital	Louisville, KY
Nicklaus Children’s Hospital	Miami, FL
Laboratory, Data Analysis, and Coordinating Center (LDACC)
New York Genome Center	New York, NY	HG012090
Massachusetts General Hospital	Boston, MA
Broad Institute	Cambridge, MA
Stanford University	Stanford, CA
Harvard Medical School	Boston, MA
Yale University	New Haven, CT	HG012108
Baylor College of Medicine	Houston, TX	HG012108
Multispecies Non-Human Primate Research Center
Oregon Health & Science University	Portland, OR	HG012483
Massachusetts Institute of Technology	Cambridge, MA
Broad Institute	Cambridge, MA
Yale University	New Haven, CT