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NIH

Andy Baxevanis, Ph.D.

Andy Baxevanis
Head
Computational Genomics Unit

Director
Bioinformatics and Scientific Programming Core

Senior Scientist
Computational and Statistical Genomics Branch

Director of Computational Biology
NIH Office of Intramural Research


B.S. Cornell University, 1984
Ph.D. The Johns Hopkins University, 1991

T: (301) 496-8570
F: (301) 480-3767
E: andy@nhgri.nih.gov
Building 50, Room 5222
50 SOUTH DR, MSC 8002
BETHESDA, MD 20892-8002

Selected Publications

Current Topics in Genome Analysis 2016

Homeodomain Resource

Hydra 2.0 Genome Project Portal

Hydractinia Genome Project Portal

Mnemiopsis Genome Project



Dr. Baxevanis' research group uses computational techniques to understand the molecular innovations that drove the surge of diversity in early animal evolution. They have focused much of this work on early branching metazoans, which predate 99 percent of all animal species. By studying our most distant animal relatives, Dr. Baxevanis' group probes the interface of genomics and developmental biology. They have interpreted the origin and evolution of a number of gene families that play a fundamental role in animal development. These include the Hox and Wnt gene families, both of which play important roles in specifying the overall body plan of a developing organism.

Recently, Dr. Baxevanis' group sequenced the genome of a comb jelly (Mnemiopsis leidyi), a member of the last major animal lineage for which there were no sequenced genomes. They showed that comb jellies, which have complex cell types such as neurons and muscle cells, are our oldest animal relatives - even predating the sponge, a simple animal without complex cell types. The Mnemiopsis genome has not only shed new light on our view of what physical and structural features were present in the earliest animals, but has also provided a new way of thinking about early animal evolution. His studies show that a surprising number of genes implicated in human disease can be identified in the earliest animals. This finding argues strongly for looking beyond the traditional set of organisms we use as experimental models. Basic biological discoveries made in organisms such as Mnemiopsis can not only give us insights into the human genome, but could lay the groundwork for translational studies focused on specific human diseases. With this in mind, Dr. Baxevanis' group has set out to sequence two Hydractinia species, colonial invertebrates that have already shown great promise for the study of regeneration.

Biography

Dr. Baxevanis is the director of Computational Biology for the National Institutes of Health's (NIH) Intramural Research Program. He is also a senior scientist leading the Computational Genomics Unit at the National Human Genome Research Institute (NHGRI).

Dr. Baxevanis' research program uses computational approaches to understand the molecular innovations that drove the surge of diversity in early animal evolution. His research group focuses on the analysis of genomes of early branching metazoan phyla to understand the relationship between genomic and morphological complexity, as well as the evolution of novel cell types. Dr. Baxevanis' group focuses specifically on invertebrate species with the potential to serve as "emerging model organisms" that can yield insights of relevance to human health.

Dr. Baxevanis received his Bachelor of Science in biological sciences from Cornell University and his Ph.D. in the Department of Biology at The Johns Hopkins University. He was a post-doctoral fellow at the National Center for Biotechnology Information at NIH, after which he joined the NHGRI faculty.

Dr. Baxevanis is co-author of the textbook Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, now in its third edition. His involvement in educational activities have included teaching bioinformatics at The Johns Hopkins University, serving as an adjunct faculty member at Boston University, and serving as the director of NHGRI's Intramural Training Office. He has also served as the co-director of the Boston University/NIH Graduate Partnerships Program in Bioinformatics. 

Dr. Baxevanis is the recipient of the Bodossaki Foundation's 2000 Academic Prize in Medicine and Biology, Greece's highest honor for young academics and scientists of Greek heritage throughout the world. In 2007, Dr. Baxevanis was awarded the IEEE Computer Society's Outstanding Achievement Award for his outstanding contributions to the field of bioinformatics. In 2014, he was elected to membership in the Johns Hopkins Society of Scholars, which recognizes alumni who have achieved marked distinction in their field of study. Dr. Baxevanis was the recipient of the NIH's Ruth L. Kirschstein Mentoring Award in 2015, in recognition of his commitment to scientific training, education and mentoring. In 2016, Dr. Baxevanis was elected as a senior member of the International Society for Computational Biology for his sustained contributions to the field.

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Last Updated: May 24, 2018