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SGFS Resources and Documents

SGFS Guidance MemoPDF file

  • Start here, describes SGFS processes in detail

SGFS ApplicationMicrosoft Word file

  • Complete the attached application and send to SGFS staff

SGFS WorkflowPDF file

Suggested Language for Protocols and ConsentPDF file

  • Suggested language to incorporate into your protocol and/or consent form describing the process of annotation and return of secondary findings through the SGFS service.  SGFS staff are available if your IRB has questions - contact Julie Sapp at sappj@mail.nih.gov for more information

Genes Currently Annotated by SGFS for Secondary FindingsPDF file

NIH Intramural Working Group on Secondary FindingsPDF file

  • Background information on the rationale behind the development and implementation of the SGFS

Darnell et al., 2016 PDF file

  • Publication outlining a proposal for a centralized service to facilitate annotation and return of secondary genomic findings as part of the research enterprise

Kalia et al., 2017PDF file

  • Recommendations from the American College of Medical Genetics for the annotation and return of actionable secondary findings in clinical sequencing; contains the "ACMG 59 gene list"


Last Updated: December 4, 2017