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NIH

Implementing Genomics in Practice (IGNITE) II: Pragmatic Clinical Trials Network

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Overview

The Implementing Genomic in Practice (IGNITE) Network was established in 2013 (RFA-HG-12-006RFA-HG-12-007 and RFA-HG-13-004) to develop methods for incorporating genomic information into clinical care and explore the methods for effective implementation, diffusion, and sustainability in diverse clinical settings. The first phase of the network, IGNITE I, was a  consortium of collaborative genomic medicine pilot Demonstration Projects designed to demonstrate the feasibility of, and develop methods for, incorporating an individual patient's genomic findings into his or her clinical care.

The next phase of IGNITE, IGNITE II (RFA-HG-17-008, RFA-HG-17-009, and RFA-HG-17-010) will support a network of multi-site Clinical Groups (CGs) involving diverse settings and populations to conduct 2-3 pragmatic clinical trials of genomic medicine interventions. The goals of these pragmatic clinical trials will be:

  1. To measure the clinical utility and cost-effectiveness of genomic medicine interventions.
  2. To assess approaches for real-world application of genomic medicine in diverse clinical settings.
  3. To produce generalizable knowledge on the types of genomic medicine interventions requiring randomized clinical trials and effective methods for conducting them

IGNITE II Investigators

Study Investigators
  • Principal Investigator: Julie Johnson, Pharm.D., University of Florida
  • Principal Investigator: Todd Skaar, Ph.D., Indiana University
    MPI: Paul Dexter, M.D., Indiana University
  • Principal Investigator: Carol Horowitz, M.P.H., M.D., Mount Sinai School of Medicine
  • Principal Investigator: Lori Orlando, M.H.S., M.D., Duke University
  • Principal Investigator: Josh Peterson, M.D., Vanderbilt University Medical Center
    MPI: Joshua Denny, M.D., Vanderbilt University Medical Center
Coordinating Center
  • Principal Investigator: Geoffrey Ginsburg, MD, PhD, Duke University School of Medicine
    MPI: Hrishikesh Chakraborty, M.S., PhD, Duke University School of Medicine

Program Contacts

NHGRI Program Directors

Simona Volpi, Pharm.D., Ph.D.
Program Lead, Division of Genomic Medicine
E-mail: simona.volpi@nih.gov

Ebony B. Madden, Ph.D., M.G.C.
Division of Genomic Medicine
E-mail: ebony.madden@nih.gov 

Nicole Lockhart, Ph.D.
Division of Genomics and Society
E-mail: lockhani@mail.nih.gov 

Jeff Struewing, M.D., M.S.
Division of Genomic Medicine
E-mail: struewij@mail.nih.gov

NHGRI Program Analyst

Michelle Cohen
Division of Genome Sciences
E-mail: michelle.cohen2@nih.gov

NHGRI Program Specialist

Sylvia M. Garvey, M.P.H., CPH
Division of Genomic Medicine
E-mail: sylvia.garvey@nih.gov

Last Updated: November 8, 2018