Mendelian Genomics Research Consortium
The Mendelian Genomics Research Consortium is aimed at significantly increasing the proportion of Mendelian disorders with an identified genetic cause through enhanced data sharing, collaboration and an increased focus on the application of new technologies, sequencing strategies and analytical approaches.
The National Human Genome Research Institute intends to fund a Mendelian Genomics Research Consortium in 2020. The program will comprise of Mendelian Genomics Research Centers (MGRC) and a Mendelian Genomics Data Coordinating Center (DCC). The MGRCs will sequence samples from patients with Mendelian conditions and develop and apply novel approaches to discover causal variants. The centers will also aim to solve “unsolved” cases for which a candidate gene was not identified by solely using whole exome sequencing. The DCC will manage data release and disseminate findings; coordinate program logistics and administrative duties; and oversee an Opportunity Fund for follow-up functional studies of discoveries made by the Mendelian centers.
Applications for the program are due on April 15th, 2020 (see below). Applicants are strongly encouraged to submit letters of intent.
NHGRI will host a pre-application webinar for the Mendelian Genomics Research Consortium funding opportunities. NHGRI staff members provide an overview of the two FOAs, the goals and objectives of the program, and the application review process. Attendees will be able to ask questions during the webinar, and are encouraged to submit questions in advance to firstname.lastname@example.org.
The webinar will take place on February 12, 2020 from 12:00-1:30 pm Eastern Standard Time.
Participation in this webinar is optional and is not required to submit an application in response to RFA-HG-20-007 or RFA-HG-20-2008. Following the webinar, a recording of the WebEx and answers to Frequently Asked Questions will be made available on the website.
Last updated: February 11, 2020