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Program Director Genome Sciences

Division of Genome Sciences

Education

Ph.D. Case Western Reserve University, 2005

Biography

Dr. Lisa Chadwick joined the National Human Genome Research Institute’s Extramural Research Program as a program director in 2018. Dr. Chadwick oversees a diverse portfolio of research grants, which include the development of novel approaches for mendelian gene discovery and the prioritization or evaluation of candidate variants, and the development of high-throughput genomic technologies related to gene expression or RNA regulation. She also oversees NHGRI’s GREGoR Program, which is working to develop new approaches to identify the causal variant in rare genetic disorders where strategies such as whole exome sequencing were not successful.   

Prior to joining NHGRI, Dr. Chadwick was a program director in the Division of Extramural Research and Training at the National Institute of Environmental Health Sciences (NIEHS) where she was involved in the leadership of the NIH Roadmap Epigenomics Program, and the NIH 4D Nucleosome Program

Dr. Chadwick received a B.A. in biology from Case Western Reserve University, a Ph.D. in genetics from Case Western Reserve University, and completed postdoctoral research at NIEHS.  

  • Biography

    Dr. Lisa Chadwick joined the National Human Genome Research Institute’s Extramural Research Program as a program director in 2018. Dr. Chadwick oversees a diverse portfolio of research grants, which include the development of novel approaches for mendelian gene discovery and the prioritization or evaluation of candidate variants, and the development of high-throughput genomic technologies related to gene expression or RNA regulation. She also oversees NHGRI’s GREGoR Program, which is working to develop new approaches to identify the causal variant in rare genetic disorders where strategies such as whole exome sequencing were not successful.   

    Prior to joining NHGRI, Dr. Chadwick was a program director in the Division of Extramural Research and Training at the National Institute of Environmental Health Sciences (NIEHS) where she was involved in the leadership of the NIH Roadmap Epigenomics Program, and the NIH 4D Nucleosome Program

    Dr. Chadwick received a B.A. in biology from Case Western Reserve University, a Ph.D. in genetics from Case Western Reserve University, and completed postdoctoral research at NIEHS.  

Publications

Wang T, Pehrsson EC, Purushotham D, Li D, Zhuo X, Zhang B et al. (TaRGET II Consortium) The NIEHS TaRGET II Consortium and environmental epigenomics. Nat Biotechnol, 36(3):225-27. doi: 10.1038/nbt.4099. 2018.

Roadmap Epigenomics Consortium et al. Integrative analysis of 111 reference human epigenomes. Nature, 518(7539):317-30. doi: 10.1038/nature14248. 2015.

Satterlee JS, Beckel-Mitchener A, McAllister K, Procaccini DC, Rutter JL, Tyson FL, Chadwick LH. Community resources and technologies developed through the NIH Roadmap Epigenomics Program. Methods Mol Biol, 1238:27-49. doi: 10.1007/978-1-4939-1804-1_2. 2015.

Chadwick LH. The NIH Roadmap Epigenomics Program data resource. Epigenomics, 4(3):317-24. doi: 10.2217/epi.12.18. 2012.

Chadwick LH, Chadwick BP, Jaye DL, Wade PA. The Mi-2/NuRD complex associates with pericentromeric heterochromatin in rapidly proliferating lymphoid cells. Chromosoma, 118(4):445-57. doi: 10.1007/s00412-009-0207-7. 2009.

Chadwick LH, Pertz LM, Broman KW, Bartolomei MS, Willard HF. Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval. Genetics, 173(4):2103-10. 2006.

Chadwick LH and Willard HF. Genetic and parent-of-origin influences on X chromosome choice in Xce heterozygous mice. Mamm Genome, 16(9):691-9. 2005.

Last updated: June 27, 2022