Polygenic Risk Score (PRS) Diversity Consortium

Members of the PRS Diversity Consortium will work together to develop and implement approaches to integrating extant genotype and phenotype data for the purpose of conducting and disseminating Consortium-wide PRS analyses.

Purpose

NHGRI intends to fund a Polygenic Risk Score (PRS) Diversity Consortium in 2021. The Consortium will comprise Study Sites and a Coordinating Center with the primary objectives of: 1) leveraging genetic diversity to develop methods and improve the applicability of PRS to predict health and disease risk across diverse populations, and for a broad range of health and disease measures; and 2) optimizing the integration of large-scale, harmonized genomic and phenotype data to facilitate collaborative analysis, dissemination of PRS-related data, and development of related methods and resources. Study Sites will convene one or more cohorts and provide scientific expertise to accomplish the Consortium research objectives. The Coordinating Center will implement overall logistical coordination, lead the data science component of the Consortium, and recruit affiliate members to the Consortium. Consortium members will work together to develop and implement approaches to integrating extant genotype and phenotype data for the purpose of conducting and disseminating Consortium-wide PRS analyses.

Purpose

NHGRI intends to fund a Polygenic Risk Score (PRS) Diversity Consortium in 2021. The Consortium will comprise Study Sites and a Coordinating Center with the primary objectives of: 1) leveraging genetic diversity to develop methods and improve the applicability of PRS to predict health and disease risk across diverse populations, and for a broad range of health and disease measures; and 2) optimizing the integration of large-scale, harmonized genomic and phenotype data to facilitate collaborative analysis, dissemination of PRS-related data, and development of related methods and resources. Study Sites will convene one or more cohorts and provide scientific expertise to accomplish the Consortium research objectives. The Coordinating Center will implement overall logistical coordination, lead the data science component of the Consortium, and recruit affiliate members to the Consortium. Consortium members will work together to develop and implement approaches to integrating extant genotype and phenotype data for the purpose of conducting and disseminating Consortium-wide PRS analyses.