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Polygenic Risk Score (PRS) Diversity Consortium

Members of the PRS Diversity Consortium will work together to develop and implement approaches to integrating extant genotype and phenotype data for the purpose of conducting and disseminating Consortium-wide PRS analyses.

Purpose

NHGRI intends to fund a Polygenic Risk Score (PRS) Diversity Consortium in 2021. The Consortium will comprise Study Sites and a Coordinating Center with the primary objectives of: 1) leveraging genetic diversity to develop methods and improve the applicability of PRS to predict health and disease risk across diverse populations, and for a broad range of health and disease measures; and 2) optimizing the integration of large-scale, harmonized genomic and phenotype data to facilitate collaborative analysis, dissemination of PRS-related data, and development of related methods and resources. Study Sites will convene one or more cohorts and provide scientific expertise to accomplish the Consortium research objectives. The Coordinating Center will implement overall logistical coordination, lead the data science component of the Consortium, and recruit affiliate members to the Consortium.  Consortium members will work together to develop and implement approaches to integrating extant genotype and phenotype data for the purpose of conducting and disseminating Consortium-wide PRS analyses.

  • Purpose

    NHGRI intends to fund a Polygenic Risk Score (PRS) Diversity Consortium in 2021. The Consortium will comprise Study Sites and a Coordinating Center with the primary objectives of: 1) leveraging genetic diversity to develop methods and improve the applicability of PRS to predict health and disease risk across diverse populations, and for a broad range of health and disease measures; and 2) optimizing the integration of large-scale, harmonized genomic and phenotype data to facilitate collaborative analysis, dissemination of PRS-related data, and development of related methods and resources. Study Sites will convene one or more cohorts and provide scientific expertise to accomplish the Consortium research objectives. The Coordinating Center will implement overall logistical coordination, lead the data science component of the Consortium, and recruit affiliate members to the Consortium.  Consortium members will work together to develop and implement approaches to integrating extant genotype and phenotype data for the purpose of conducting and disseminating Consortium-wide PRS analyses.

Funding Opportunities

  • RFA-HG-20-001 Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry Centers (U01 Clinical Trial Not Allowed)
    Expiration Date: Jun 24, 2020

    • NOT-HG-20-005 Notice of Intent to Publish a Funding Opportunity Announcement for Centers for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry (U01 Clinical Trial Not Allowed)

    • NOT-HG-20-006 Notice of Intent to Publish a Funding Opportunity Announcement for a Coordinating Center for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry (U01 Clinical Trial Not Allowed)

    • NOT-HG-20-010 Notice of Special Interest: Development of Statistical, Population Genetics and Computational Methods Related to Polygenic Prediction of Health and Disease in Diverse Populations

    • NOT-HG-20-038 Pre-Application Webinar for RFA-HG-20-001 and RFA-HG-20-002, Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry Study Sites and Coordinating Center (U01 Clinical Trial Not Allowed)

  • RFA-HG-20-002 Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry Coordinating Center (U01 Clinical Trial Not Allowed)
    Expiration Date: Jun 24, 2020

    • NOT-HG-20-005 Notice of Intent to Publish a Funding Opportunity Announcement for Centers for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry (U01 Clinical Trial Not Allowed)

    • NOT-HG-20-006 Notice of Intent to Publish a Funding Opportunity Announcement for a Coordinating Center for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry (U01 Clinical Trial Not Allowed)

    • NOT-HG-20-010 Notice of Special Interest: Development of Statistical, Population Genetics and Computational Methods Related to Polygenic Prediction of Health and Disease in Diverse Populations

    • NOT-HG-20-038 Pre-Application Webinar for RFA-HG-20-001 and RFA-HG-20-002, Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry Study Sites and Coordinating Center (U01 Clinical Trial Not Allowed)

Program Staff

Lucia Hindorff, Ph.D., M.P.H.
Lucia Hindorff, Ph.D., M.P.H.
  • Epidemiologist
  • Division of Genomic Medicine
Ken Wiley, Jr., Ph.D.
Ken Wiley Jr, Ph.D.
  • Program Director
  • Division of Genomic Medicine
Damali Martin
Damali N. Martin, Ph.D., M.P.H.
  • Health Science Administrator
  • National Cancer Institute
Catherine Sillari
Catherine Sillari
  • Program Analyst
  • Division of Genomic Medicine

Last updated: May 19, 2020