NIH

Edward Giniger, Ph.D.

Adjunct Investigator, Genetics and Molecular Biology Branch
Senior Investigator, National Institute of Neurological Disorders and Stroke [ninds.nih.gov]

Selected Publications

Giniger, E. How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics. Differentiation, 70: 385-396. 2002. [PubMed]

Crowner, D., Le Gall, M., Gates, M.A. and Giniger, E. Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol, 13: 967-972. 2003. [PubMed]

Goeke, S., Greene, E.A., Gates, M.A., Grant, P.K., Crowner, D., Aigaki, T. and Giniger, E. Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila. Nature Neuroscience, 6: 917-924. 2003. [PubMed]

Horiuchi, T. Giniger, E. and Aigaki, T. Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola. Genes, Dev 17: 2496-2501. 2003. [PubMed]

Connell-Crowley, L., Vo, D., Luke, L., Giniger E. Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Mech of Dev, 124(5):341-9. 2007. [PubMed]

Le Gall, M., DeMattei, C. and Giniger, E. Molecular separation of two signaling pathways for the receptor, Notch." Dev. Biol, 313:556-567. 2008. [PubMed]

J.K. Song, R. Kannan, G. Merdes, J. Singh, M. Mlodzik and E. Giniger. Disabled is a bona fide component of the Abl signaling network. Development. 137(21):3719-27. [PubMed]

Kuzina, I., Song, J.K. and Giniger, E. How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. Development,138:1839-49. 2011. [PubMed]

Trunova, S., Baek, B. and Giniger, E. Cdk5 regulates the size of an AIS-like compartment in mushroom body neurons of the Drosophila central brain. J. Neurosci. 31:10451-62. 2011. [PubMed]

Gates, M.A., Kannan, R. and Giniger, E. A genome-wide analysis reveals that the Drosophila transcription factor, Lola, promotes axon growth in part by suppressing expression of the actin nucleation factor, Spire. Neural Development, 6:37. 2011. [PubMed]

Trunova, S. and Giniger, E. Absence of the Cdk5 activator, p35, causes adult-onset neurodegeneration in the central brain of Drosophila. Dis Model Mech, 5(2):148. 2012. [PubMed]

Shivalkar, M. and Giniger, E. Control of dendritic morphogenesis by Trio in Drosophila melanogaster. PLoS ONE, 7(3): e33737. 2012. [PubMed]

Giniger, E. Notch signaling and neural connectivity. Curr Opin Genet and Devel, 22: 339-346. 2012. [PubMed]

McLinden, K.A., Trunova, S. and Giniger, E. At the fulcrum in health and disease: Cdk5 and the balancing acts of neuronal structure and physiology. Brain Disorders and Therapy, S1:001. doi 10.4172/2168-975X.S1-001. 2012. [PubMed]

Ferreira, T. Ou, Y., Li, S., Giniger, E. and van Meyel, D. Dendrite architecture organized by transcriptional control of the F-actin nucleator Spire. Development, 141(3):650-60. 2014. [PubMed]

Kannan, R., Kuzina, I., Wincovitch, S., Nowotarski, S.H., and Giniger, E. The Abl/Enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons. Mol Biol of the Cell, 25:2993-3005. 2014. [PubMed]

Smith-Trunova, S., Prithviraj, R., Spurrier, J., Kuzina, I., Gu, Q. and Giniger. E. Cdk5 regulates developmental remodeling of mushroom body neurons in Drosophila. Dev Dynamics, 244:1550-1563. 2015. [PubMed]

Top of page

Last Updated: December 9, 2015