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Implementing Genomics in Practice (IGNITE)



Findings from the genomics field have slowly started to find applications in clinical care. The field of "genomic medicine" could potentially improve patient health and treatment strategies or better predict the likelihood of disease.

The Implementing Genomics in Practice (IGNITE) consortium (RFA-HG-12-006, RFA-HG-12-007 and RFA-HG-13-004) was created to enhance the use of genomic medicine by supporting the development of methods for incorporating genomic information into clinical care and exploration of the methods for effective implementation, diffusion and sustainability in diverse clinical settings. 

These demonstration projects will incorporate genomic information into the electronic medical record (EMR) and provide clinical decision support (CDS) for implementation of appropriate interventions or clinical advice. The sites will work together to develop new methods and projects and disseminate their findings to the public. Dissemination of these methods and developing best practices for implementation is a key goal so that the information generated from the program will contribute to the growing knowledge base of using genomic information in patient care.

IGNITE Investigators

Study Investigators
  • Genomic Diagnosis and Personalized Therapy for Highly Penetrant Genetic Diabetes
    Principal Investigator: Toni Pollin, Ph.D., University of Maryland 
  • Genomic Medicine Implementation: The Personalized Medicine Program (PMP)
    Principal Investigator: Julie Johnson, Pharm.D., University of Florida

  • Indiana GENomics Implementation, an Opportunity for the UnderServed (INGENIOUS)
    Principal Investigator: Todd Skaar, Ph.D., Indiana University
    Co-PI: Paul Dexter, M.D., Indiana University
  • Genetic testing to Understand and Address Renal Disease Disparities (The GUARDD Study)
    Principal Investigator: Carol Horowitz, M.P.H., M.D., Mount Sinai School of Medicine

  • Implementation, Adoption, and Utility of Family History in Diverse Care Settings
    Principal Investigator: Geoffrey Ginsburg, M.D., Ph.D., Duke University
    Co-PI: Lori Orlando, M.H.S., M.D., Duke University

  • Integrated, Individuals, Intelligent Prescribing (I3P)
    Principal Investigator: Joshua Denny, M.D., Vanderbilt University
    Co-PI: Mia Levy, M.D., Ph.D., Vanderbilt University

Administrative Coordinating Center
  • Principal Investigator: Geoffrey Ginsburg, MD, PhD, Duke University School of Medicine
    Co-PI: Lori Orlando, M.H.S., M.D., Duke University

IGNITE Network Site Locations


IGNITE Sites on U.S. Map

Affiliate Members
  • Cincinnati Children's Hospital Medical Center
  • H. Lee Moffitt Cancer Center & Research Institute - DeBartolo Family Personalized Medicine Institute
  • Kaiser Permanente Research Bank
  • MD Labs - Rxight Pharmacogenetics
  • Mission Health System - Personalized Medicine Program
  • Nemours Children's Health System - Nemours Children's Hospital
  • Nicklaus Children's Hospital - Nicklaus Children's Hospital Personalized Medicine Initiative
  • OneOme
  • St. Lukes' Mountain States - Tumor Institute
  • The Jackson Laboratory
  • The University of Alabama Birmingham
  • University of California, San Francisco - Center for Translational and Policy Research on Personalized Medicine (TRANSPERS)
  • University of Colorado - Anschutz Medical Campus
  • University of Illinois at Chicago - College of Pharmacy Personalized Medicine Program
  • University of Minnesota
  • University of North Carolina at Chapel Hill - Center for Pharmacogenomics and Individualized Therapy
  • University of Pittsburgh - School of Pharmacy Institute of Personalized Medicine

IGNITE Affiliates on U.S. Map

Project Website at the University of Florida

Meetings and Workshops

Program Contacts

NHGRI Program Directors

Ebony B. Madden, Ph.D., M.G.C.
Division of Genomic Medicine

Nicole Lockhart, Ph.D.
Division of Genomics and Society

Jeff Struewing, M.D., M.S.
Division of Genomic Medicine

Simona Volpi, Pharm.D., Ph.D.
Division of Genomic Medicine

NHGRI Program Analyst

Michelle Cohen
Division of Genome Sciences

NHGRI Program Specialist

Sylvia M. Garvey, M.P.H., CPH
Division of Genomic Medicine

Last Updated: September 22, 2018