Division of Genomic Medicine

The division plans, directs and facilitates multi-disciplinary research to identify genetic contributions to human health and to advance approaches for the use of genomic data to improve diagnosis, treatment and prevention of disease; through research grants, research training grants, and contracts. The division also:

• Determines program priorities in genomic medicine and related areas and recommends funding levels.  
• Assesses needs for research and research training in genomic medicine and related areas.  
• Prepares reports and analyses to assist Institute staff and advisory groups in carrying out their responsibilities.  
• Collaborates with the other NHGRI extramural research divisions to establish a balance of resources, personnel, and research and training budgets to achieve NHGRI goals.  
• Provides expert advice to the director of NHGRI on various aspects of genomic medicine.  
• Collaborates with the other NHGRI divisions, other National Institutes of Health Institutes and Centers (ICs), and other agencies and entities, national and internationally and maintains an awareness of research efforts in relevant program areas.

• Revisiting the Missing Heritability of Complex Diseases, Ten Years On
  May 1-2, 2018, Silver Spring, Md.
   
• Genomic Medicine for Reproductive, Prenatal and Neonatal Health
  April 16-17, 2018, Bethesda, Md.
   
• eMERGE & Beyond: The Convergence of Genomics and Medicine
  February 2, 2017, Bethesda, Md.
   
• IGNITE and Beyond: The Future of Genomic Medicine Implementaiton
  August 30, 2016, Bethesda, Md.
   
• NHGRI International Genomics Education Meeting
  August 4-5, 2016, Bethesda, Md.
   
• Research Directions in Genetically-Mediated Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
  March 3-4, 2015, Bethesda, Md.
   
• Implicating Sequence Variants in Human Disease
  September 12-13, 2012, Bethesda, Md.
   
• Sequencing in Cohort Studies and Large Sample Collections
  June 28-29, 2012, Bethesda, Md.
   
• Characterizing and Displaying Genetic Variants for Clinical Action Workshop
  Dec. 1-2, 2011, Gaithersburg, Md.
   
• Gene-Environment Interplay in Common Complex Diseases: Forging an Integrative Model 
  January 25, 2010, Bethesda, Md.
   
• New Models for Large Prospective Studies Symposium
  January 22, 2010, Bethesda, Md.
   
• The Dark Matter of Genomic Associations with Complex Diseases: Explaining the Unexplained Heritability from Genome-Wide Association Studies
  February 2-3, 2009, Bethesda, Md.
   
• Epidemiology for Researchers Performing Genetic/Genomic Studies
  July 18, 2008, Bethesda, Md.
   
• Genetics for Epidemiologists: Application of Human Genomics to Population Sciences
  May 13-14, 2008, Chicago, Ill.
   
• Frontiers in Population Genomics Research Meeting
  December 18-19, 2007 in Bethesda, Md.
   
• Designing Geneticists: Study Design Issues in Population-Based Genetics and Genomics Research
  October 23-27, 2007, San Diego, California
   
• Genome-Wide Association Studies for the Rest of Us: Adding Genome-Wide Association to Population Studies
  June 22, 2007, Boston, Mass.
   
• Multi-IC Symposia on the Application of Genomic Technologies to Population-Based Studies: Facilitating Collaboration in Genome-Wide Association Studies
  May 22-23, 2007, Bethesda, Md.
  June 5-6, 2006, Bethesda, Md.

2017

• RFA-RM-17-015 Metabolomics Core for the Undiagnosed Diseases Network (UDN) Phase II (U01)
  Release Date: August 15, 2017

• RFA-RM-17-016 Sequencing Core(s) for the Undiagnosed Diseases Network (UDN) Phase II (U01)
  Release Date: August 15, 2017

• RFA-RM-17-017 Model Organisms Screening Center for the Undiagnosed Diseases Network (UDN) Phase II (U54)
  Release Date: August 15, 2017

  • Notice of Correction to the Award Budget for the RFA-RM-17-017 Model Organism Screening Center for the Undiagnosed Diseases Network (UDN) Phase II (U54)
    Release Date: August 15, 2017
     
• RFA-RM-17-018 Coordinating Center for the Undiagnosed Diseases Network (UDN) Phase II (U01)
   
• RFA-RM-17-019 Clinical Sites for the Undiagnosed Diseases Network (UDN) Phase II (U01)
  Release Date: August 15, 2017
   
• RFA-HG-17-011 The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) (U24)
  Application Due Date(s): November 9, 2017
  Expiration Date: November 10, 2017
  • For additional information, please visit the NHGRI Genomic Data Science AnVIL webpage.
     
• NOT-HG-17-014 Notice of Applicant Information Webinar and Frequently Asked Questions (FAQ) for NHGRI IGNITE II RFAs: RFA-HG-17-008, RFA-HG-17-009 and RFA-HG-17-010
   
  • Frequently Asked Questions about IGNITE II
     
• RFA-HG-17-008 Implementing Genomics in Practice (IGNITE) II: Pragmatic Clinical Trials - Clinical Groups (U01) 
  Application Due Date(s): November 3, 2017
  Expiration Date: November 4, 2017
   
• RFA-HG-17-009 Implementing Genomics in Practice (IGNITE) II: Pragmatic Clinical Trials -Enhanced Diversity Clinical Groups (U01)
  Application Due Date(s): November 3, 2017
  Expiration Date: November 4, 2017
   
• RFA-HG-17-010 Implementing Genomics in Practice (IGNITE) II: Pragmatic Clinical Trials -Coordinating Center (U01)
  Application Due Date(s): November 3, 2017
  Expiration Date: November 4, 2017

2016

• RFA-HG-16-010 Clinical Sequencing Evidence-Generating Research (CSER2) - Clinical Sites (U01)

  • NOT-HG-16-021 Notice Announcing Pre-application Information Webinar for Clinical Sequencing Evidence-generating Research (CSER2) Requests For Applications (RFAs) and Frequently Asked Questions (FAQ) regarding Clinical Sequencing Funding Opportunities
    Release Date: May 6, 2016
     
• RFA-HG-16-011 Clinical Sequencing Evidence-Generating Research (CSER2) - Clinical Sites with Enhanced Diversity (U01)
  Release Date: May 6, 2016
   
• RFA-HG-16-012 Clinical Sequencing Evidence-Generating Research (CSER2) - Coordinating Center (U24)
  Release Date: May 6, 2016
   
• PAR-16-209 Investigator-Initiated Clinical Sequencing Research (R01) 
  Release Date: April 19, 2016

• PAR-16-274 Serious Adverse Drug Reaction Research (R21) 
  Release Date: May 19, 2016

• PAR-16-275 Serious Adverse Drug Reaction Research (R01) 
  Release Date: May 19, 2016

• PAR-16-435 Genomics of HIV/AIDS Drug Response and Co-Morbidities (R01) 
  Release Date: September 16, 2016

2015

• NOT-HG-15-014 Notice of Pre-Application Webinar for PA-14-015 "Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (Parent T32)" Related to the Creation of New NHGRI Postdoctoral Training Programs in Genomic Medicine Research
  Release Date: February 5, 2015

2014

• NOT-HG-14-017 Notice of NHGRI Participation in PA-14-015 "Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (Parent T32)" and Creation of New NHGRI Postdoctoral Training Programs in Genomic Medicine Research 
  Release Date: January 10, 2014
   
• RFA-HG-14-025 The Electronic Medical Records and Genomics (eMERGE) Network, Phase III - Study Investigators (U01)
  Release Date: July 9, 2014
   
• RFA-HG-14-026 The Electronic Medical Records and Genomics (eMERGE) Network, Phase III - Coordinating Center (U01)
  Release Date: July 17, 2014
   
• RFA-HG-14-027 The Electronic Medical Records and Genomics (eMERGE) Network, Phase III - Central Genome Sequencing and Genotyping Facility (U01)
  Release Date: July 17, 2014
   
  • Frequently Asked Questions for the Electronic Medical Records and Genomics (eMERGE) Network, Phase III RFAs

2013

• RFA-HD-13-010 Genomic Sequencing and Newborn Screening Disorders (U19)
  Release Date: August 9, 2012

2012

• RFA-HG-12-016 Clinically Relevant Genetic Variants Resource: A Unified Approach for Identifying Genetic Variants for Clinical Use (U01)
  Release Date: July 10, 2012
   
  • Frequently Asked Questions about RFA-HG-12-016
     
• RFA-HG-12-015 Population Architecture Using Genomics and Epidemiology (PAGE), Phase II Coordinating Center (U01)
  Release Date: June 20, 2012
   
• RFA-HG-12-010 Population Architecture Using Genomics and Epidemiology (PAGE), Phase II Study Investigators (U01)
  Release Date: June 20, 2012 
   
• NOT-HG-11-023 Notice of Intent to Publish a Request for Applications for The Electronic Medical Records and Genomics (eMERGE) Network - Pediatric Study Investigators
  Release Date: June 14, 2011 
   
• RFA-HG-12-007 Genomic Medicine Pilot Demonstration Projects Coordinating Center (U01)
  Release Date: April 3, 2012
   
• RFA-HG-12-006 Genomic Medicine Pilot Demonstration Projects (U01)
  Release Date: April 3, 2012
  • Frequently Asked Questions about the Genomic Medicine Pilot Demonstration Projects (U01)

2011

• NOT-HG-11-021 Notice of the National Human Genome Research Institute's Interest in Receiving Applications to Analyze and Develop Methods for X Chromosome Genome-wide Association (GWA) Data
  Release Date: June 1, 2011
   
• NOT-HG-11-009 Notice of Amendment and Re-issuance of Administrative Supplements for the Addition of Standard Measures to Population-based Genomic Research: The PhenX Toolkit
  Release Date: January 21, 2011
   
• RFA-HG-11-022 The Electronic Medical Records and Genomics (eMERGE) Network, Phase II - Pediatric Study Investigators (U01)
  Release Date: July 6, 2011

2010

• PAR-11-032 Methods and Approaches for Detection of Gene-Environment Interactions in Human Disease (R21)
  Release Date: November 12, 2010
   
• NOT-HG-11-001 Notice of Availability of Administrative Supplements for the Addition of Standard Measures to Population-Based Genomic Research: The PhenX Toolkit
  Release Date: October 8, 2010
   
• RFA HG-10-009 The Electronic Medical Records and Genomics (eMERGE) Network, Phase II - Study Investigators (U01)
  Release Date: July 16, 2010
   
• RFA HG-10-010 The Electronic Medical Records and Genomics (eMERGE) Network, Phase II - Coordinating Center (U01)
  Release Date: July 16, 2010

2009

• NOT-HG-08-013 Notice of Publication of FAQs Related to RFA-HG-08-004: Genome-wide Association Studies of Treatment Response in Randomized Clinical Trials - Study Investigators (U01) 
  Release Date: September 12, 2008
   
• NOT-HG-08-012 Correction for RFA-HG-08-005: Genome-wide Association Studies of Treatment Response in Randomized Clinical Trials - Coordinating Center (U01)
  Release Date: September 12, 2008
   
• NOT-OD-07-088 Policy for Sharing of Data Obtained in NIH Supported or Conducted Genome-Wide Association Studies (GWAS)
  Release Date: August 28, 2007
   
  • Developed following a public consultation process with interested stakeholders, the GWAS data-sharing policy will facilitate the research community's access to genotype-phenotype datasets from GWAS in a broad array of disease areas.
     
  • GWAS Oversight Structure
    A chart of the governance of data-release policy for GWAS

• NOT-OD-08-013 Implementation Guidance and Instructions for Applicants: Policy for Sharing of Data Obtained in NIH-Supported or Conducted Genome-Wide Association Studies (GWAS)
  Release Date: November 16, 2007
   
• RFA-HG-09-014 Comparing Design Approaches for Sequencing Disease-Associated Regions Found in Genome-Wide Association Studies (U01)
  Letters of Intent Receipt Date(s): November 12, 2009; Application Receipt Date: December 11, 2009
   
• RFA-HG-09-004 Follow-up Public Consultation to Inform the Design of a Possible Longitudinal Cohort Study of the Role of Genes and Environment in Health and Disease: Limited Competition (U01) 
  Letters of Intent Receipt Date(s): January 3, 2009; Application Receipt Date: February 3, 2009
   
• RFA-MH-09-120 Informing Systems Biology through Genetic Variation: The Genes, Environment and Health Initiative (R21)
  Letters of Intent Receipt Date(s): December 14, 2008; Application Receipt Date: January 14, 2009

2008

• NOT-CA-08-011 Administrative Supplements for Gene Identification Efforts: Replication and Fine-Mapping Studies for The Genes, Environment, and Health Initiative (GEI)
  Release Date: March 5, 2008
   
• RFA-CA-09-003 Replication and Fine-Mapping Studies for the Genes, Environment, and Health Initiative (GEI) (R01)
  Letters of Intent Receipt Date(s): October 24, 2008; Application Receipt Date: December 1, 2008
   
• RFA-DK-08-003 Implementation Planning Grants for Educational, Behavioral, or Social Studies for Translation of Genetic Factors in Common Diseases (U34)
  Letters of Intent Receipt Date(s): October 24, 2008; Application Receipt Date: November 25, 2008 
   
• RFA-DK-08-004 Translation of Common Disease Genetics into Clinical Applications (R21) 
  Letters of Intent Receipt Date(s): October 24, 2008; Application Receipt Date: November 25, 2008
   
• RFA-HG-08-004 Genome-wide Association Studies of Treatment Response in Randomized Clinical Trials - Study Investigators (U01) 
  Letters of Intent Receipt Date(s): October 13, 2008; Application Receipt Date: November 13, 2008
   
  • Frequently asked questions about RFA-HG-08-004
     
• RFA-HG-08-005 Genome-wide Association Studies of Treatment Response in Randomized Clinical Trials - Coordinating Center (U01) 
  Letters of Intent Receipt Date(s): October 13, 2008; Application Receipt Date: November 13, 2008
   
• RFA-DA-09-003 Functional Characterization of Genetic Variants and Interactions: The Genes, Environment and Health Initiative (R21)
  Letters of Intent Receipt Date(s): September 17, 2008; Application Due Date(s): October 17, 2008
   
• RFA-DA-09-004 Functional Characterization of Genetic Variants and Interactions: The Genes, Environment and Health Initiative (R03) 
  Letters of Intent Receipt Date(s): September 17, 2008; Application Due Date(s): October 17, 2008
   
  • Genomic Applications in Practice and Prevention (GAPP): Translation Programs in Education, Surveillance, and Policy [cdc.gov]

2007

• RFA-HG-07-005 Genome-Wide Studies in Biorepositories with Electronic Medical Record Data (U01)
   
  • Audio Recording of Pre-Application Technical Assistance Meeting for RFA-HG-07-005 [webmeeting.nih.gov]
     
• RFA-HG-07-006 High-Priority Phenotype and Exposure Measures for Cross-Study Analysis in Genome-Wide Association Studies (U01)
   
• RFA-HG-07-012 Genome-wide Association Studies in the Genes, Environment, and Health Initiative - Study Investigators (U01) (re-issue of RFA-HG-06-033)
   
• RFA-HG-07-014 Epidemiologic Investigation of Putative Causal Genetic Variants-Study Investigators (U01)
   
  • Frequently Asked Questions About RFA-HG-07-014
     
• RFA-HG-07-015 Epidemiologic Investigation of Putative Causal Genetic Variants-Coordinating Center (U01)
  
  NOT-LM-07-001 Genotype and Phenotype Data Now Available from dbGaP Database; Request Process Involves New Procedures for Principal Investigators and Signing Officials
   
• NOT-HG-08-001 Notice of Publication of FAQs Related to RFA-HG-07-014: Epidemiologic Investigation of Putative Causal Genetic Variants-Study Investigators (U01)
  Release Date: October 16, 2007
   
• NOT-HG-07-026 Notice to Allow Resubmissions to RFA-HG-07-012: Genome-wide Association Studies in the Genes, Environment, and Health Initiative - Study Investigators (U01)
   
• NOT-OD-07-066 Notice of Availability of the Data Access Request System for the Genetic Association Information Network (GAIN)

2006

• RFA-HG-06-014 Genome-wide Association Studies in the Genes and Environment Initiative - Genotyping Facilities (U01)
   
  • Frequently Asked Questions About RFA-HG-06-014
     
• RFA-HG-06-032 Genome-wide Association Studies in the Genes and Environment Initiative - Coordinating Center (U01)
   
  • Frequently Asked Questions About RFA-HG-06-32
     
• RFA-HG-06-033 Genome-wide Association Studies in the Genes and Environment Initiative - Study Investigators (U01)
   
  • Frequently Asked Questions About RFA-HG-06-33
     
• RFA-HG-06-008 Public Consultation to Inform the Design of Possible Large-Scale Studies of Genes and Environment in Common Disease (U01)