$1,000 Genome Program
Driving down the cost of sequencing by developing new methods.
Overview
In 2004, NHGRI initiated a coordinated effort to support the development of technologies to dramatically reduce the cost of DNA sequencing, a move aimed at broadening the applications of genomic information in biomedical research and health care. Some of the successes of this program, which culminated in 2014, are described in Nature: “Technology: The $1,000 Genome.” The history and achievements of the $1,000 Genome Program, which was led by Dr. Jeffery Schloss, as the Sequencing Technology Development Program Director at NHGRI, are further highlighted below.
Setting the Stage
Below are program reports from workshops leading up to the start of the $1,000 Genome Program.
- Sequencing and Re-Sequencing the Biome!
July 2002
- Sequencing Technology Workshop
May 1998
- Functional Analysis Workshop
December 1997
- Sequencing Variation Workshop
March - April 1997
The concept papers linked below were discussed at the May 2003 meeting of the National Advisory Council for Human Genome Research (NACHGR). Describing future plans for NHGRI’s Sequencing Technology Development Program, the concept papers paved the way for some of the first Funding Opportunity Announcements of the $1,000 Genome Program in early 2004.
- Concept Papers for Two DNA Sequencing Technology Development Programs (May 2003 Council)
Advanced Sequencing Technology Awards
- NIH awards $14.5 million to research groups studying newest DNA sequencing techniques
August 2014
- New NIH awards focus on nanopore technology for DNA sequencing
September 2013
- New NIH/NHGRI grants to harness nanoscale technologies to cut DNA sequencing costs September 2012
- NHGRI funds development of revolutionary DNA sequencing technologies
August 2011
- NHGRI funds development of third generation DNA sequencing technologies
September 2010
- NHGRI Uses Recovery Act Funds to Accelerate Genome Research to Improve Human Health October 2009
- NHGRI Seeks DNA Sequencing Technologies Fit for Routine Laboratory and Medical Use
August 2008
- New Grants Bolster Efforts to Generate Faster and Cheaper Tools for DNA Sequencing
August 2007
- NHGRI Aims to Make DNA Sequencing Faster, More Cost Effective
October 2006
- NHGRI Expands Effort to Revolutionize Sequencing Technologies
August 2005
- NHGRI Seeks Next Generation of Sequencing Technologies
October 2004
Publications and Patents
In the document linked below, listed by Principal Investigator, are citations and links to many of the articles and patents resulting from the $1,000 Genome Program and closely related research from 2004 to 2014.
News and Events
The following resources highlight noteworthy events and developments on the road to the $1,000 genome.
- Cultivating DNA Sequencing Technology After the Human Genome Project
August 2020
- Nanopore DNA sequencing: New approaches to an old challenge
December 2013
- Genome Advance of the Month - Proteus: Discovering the tiniest disease-causing flaws - and improving sequencing technologies
July 2011
- The Road to the $1000 Genome Via Nanopores - A Roundup of Sequencing Technology Developments
February 2011
- The Road to the $1000 Genome - A Roundup of Sequencing Technology Developments
August 2010
Last updated: March 25, 2022