Research at NHGRI
The Division of Intramural Research conducts a broad program of laboratory and clinical research.

Investigating why cancer comes back

Read moreFor a patient with cancer, two of the most important words in the oncologist's lexicon begin with the letter "r": remission and relapse. Why do some patients stay in remission, while others see their cancer return? In recent research published online in July in the journal Leukemia, Paul Liu, M.D., Ph.D., a senior investigator, and Raman Sood, Ph.D., an associate investigator, for the Translational and Functional Genomics Branch at NHGRI, are trying to understand why leukemia patients relapse, and if there are any DNA-level mutations that account for the leukemia coming back. Read more

An ancient tumor in dogs might teach new tricks about cancer in people

Read more An ancient, sexually transmitted dog cancer has baffled researchers until now. Canine transmissible venereal tumor, CTVT, spreads when cancer cells move from one dog to another during sexual contact. By comparing the genomes of 186 healthy dogs to two of the dog tumor genomes, NHGRI researchers discovered genetic mutations that prevented the dogs' immune systems from detecting and fending off invading cancer cells. Findings were reported in the July 31, 2015 journal, Genome Research. Read more

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Charting a course for genomic sequencing in patient care

Read moreIn the nearly four years since its launch, the Clinical Sequencing Exploratory Research (CSER) program has made significant strides in defining the role of genomics in medicine. CSER is nearing the end of its first round of research awards. To help identify the direction of a potential follow-up program, CSER investigators and colleagues recently met in Bethesda, Maryland, for a one-day conference, Integrating Genomic Sequencing into Clinical Care: CSER and Beyond. Read more.

Undiagnosed Diseases Network launches online application portal

Read moreThe Undiagnosed Diseases Network (UDN), a clinical research initiative of the National Institutes of Health (NIH), has opened an online patient application portal called the UDN Gateway. Introduction of this application system sets the stage for the network to advance its core mission: to diagnose patients who suffer from conditions that even skilled physicians have been unable to diagnose despite extensive clinical investigation. Read more

Last Updated: November 25, 2015