New NIH grants will fund developing computational approaches to finding the differences in DNA that make people susceptible to disease. The awards, totaling around $11.1 million, support research in identifying these differences - or genetic variants - in the less-studied regions of the genome. Understanding these variants should provide clues to understanding how disease develops.
The National Human Genome Research Institute, a component of the National Institutes of Health (NIH) and the Department of Health and Human Services (DHHS), is seeking exceptional candidates for the position of Director, Division of Genome Sciences. The ideal candidate will have the knowledge and expertise to lead NHGRI's funding for extramural research and training that is aimed at advancing the understanding of the structure and function of genomes and their implications for biology and disease etiology.
The practice of medicine is expensive and doesn't fit in a one-hour time frame. Tests can only eliminate one diagnosis at a time. Questioning and family history can help a doctor arrive at the correct diagnosis. But even with the information gathered upfront, there are a huge number of tests to consider, and many tests may still be needed. Training doctors to use genomic sequencing is a powerful solution to the challenges today's medical practice.
A new mouse model of Zika virus infection in pregnancy is offering clues about how the virus works. Researchers at Washington University School of Medicine in St. Louis showed that the virus migrated from the pregnant mouse's bloodstream into the placenta, eventually infecting, and causing cell death, in the brains of the unborn pups. Using this mouse model, researchers hope to learn about the virus' biology and develop new vaccines and treatments. The research, co-funded by NHGRI, appears in Cell.
An international team of scientists from the 1000 Genomes Project Consortium has created the world's largest catalog of genomic differences among humans, providing researchers powerful clues to why some people are susceptible to various diseases. Understanding how these differences - called genomic variants - contribute to disease may help clinicians develop improved diagnostics, treatments and prevention methods. The two studies are published online in Nature.