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CRGGH Staff

The Center for Research on Genomics and Global Health (CRGGH) aims to develop a comprehensive staff and training program that uses genomic approaches to study human health and to reduce/eliminate health disparities, with particular attention given to the inclusion of scholars from underrepresented populations.

Meet the Director

Charles Rotimi

Dr. Charles N. Rotimi is the Director of the Center for Research on Genomics and Global Health (CRGGH) and Chief and Senior Investigator in the Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch of the National Human Genome Research Institute, National Institutes of Health (NIH). His research activities have focused on identifying the genetic, social, and lifestyle determinants of diseases of major public health importance. He believes that studying diverse human populations is critically important in the global effort to use genomic tools to better understand human evolutionary history, and how this history may inform individual and group susceptibility/resistance to disease and variable response to drugs. To achieve these goals, Dr. Rotimi's lab has established major genetic epidemiology research projects in multiple ethnic groups in the United States, Africa (Nigeria, Ghana, Kenya, and Ethiopia) and China. The CRGGH was established to support and expand these global efforts.

Overall, Dr. Rotimi believes that scientific activities operate within the larger context of society and that the junction of society and science has to be managed so as not to trample upon the independence required for good scholarly investigation or to alienate members of societies from the scientific process. In this regard, the CRGGH is interested in how scientists document and describe the nonrandom pattern of human genetic variation and its link to disease risks in different populations. For example, how does human genetic variation inform our understanding of self and group identity and differential distribution of diseases? Investigators at the CRGGH are directly involved in these debates and hope to inform the interpretation of human genetic variation within the context of health disparities and group identity.

Dr. Rotimi received his undergraduate education in biochemistry from the University of Benin in Nigeria before immigrating to the United States for further studies. Dr. Rotimi started his education in the United States at the University of Mississippi where he obtained a Master's degree in Health Care Administration. He obtained a second Master's degree and a Doctorate in Epidemiology from the University of Alabama at Birmingham School of Public Health. Prior to coming to the NIH, Dr. Rotimi was the Director of the National Human Genome Center at Howard University. In his continued efforts to include the African community (both public and scientific), Dr. Rotimi provided leadership for the establishment of the African Society of Human Genetics and served as its president for 10 years.

Read excerpts from an interview in The Lancet, October 2010 Vol. 376, #9750):

Inequality is "one of the most outrageous aspects of society", says Charles Rotimi. That is why, earlier this year, he fulfilled "a lifetime achievement", with the launch of the Human Heredity and Health in Africa project (H3Africa), an international partnership to support population-based genetic studies on that continent. For Rotimi, understanding human genetic variation through genomics is important in global efforts to reduce health disparities, and these endeavours must "ensure all human populations are engaged in the use of genomics to solve societal problems from hunger to health".

Rotimi "has demonstrated unequivocally that 'because it had not been done before' was no excuse for not including Africa and the African diaspora in the human genome revolution", comments Georgia Dunston, founding and acting Director of the National Human Genome Center (NHGC) at Howard University, Washington, DC. Rotimi is concerned to involve Africans in genetic epidemiology, both as participants and researchers. "There is only one human race", Rotimi says. "One common characteristic of humans is that we like to travel and to share our genetic inheritance and with each such interaction we change the genetic attributes of human populations." Thus, a comprehensive understanding of population and ethnic differences requires a robust appreciation of human history: "At a fundamental level", he says, "we are all Africans beneath our skin."

What Rotimi does not study is race. "If we look at pharmacogenomics and social groups — Africans, black, white, Hispanic, and so on — it's pretty clear that at the level of drug metabolising enzymes, genes don't align themselves in a consistent manner with social labels". Members of the same family or ethnic group, for example, may carry different copies of important drug metabolising enzymes, and similar observations are true for genes important for human diseases. So, Rotimi explains, the classification of research populations "should be driven by the questions we want to answer". Continental origin is important, for example, when variations have been driven by historical environmental differences, such as climate, farming practices, and diet. Consideration of ethnic groups "gives us flexibility to account for the dynamic nature of both inherited and cultural characteristics", says Rotimi. Thus, he advocates ethnic labelling of study populations because "it captures the dynamic nature of human relationships that 'race' does not allow — 'race' connotes fixed boundaries — one pure group", he says.

You can also read Dr. Rotimi's interview in Nature Genetics as he answers questions on the role genomics plays in eliminating and addressing health disparities. (Note: the CRGGH was initially referred to as the NIH Intramural Center for Genomics and Health Disparities): Rotimi C. Straight talk with... Charles Rotimi. Interview by Charlotte Schubert. Nat Med, 14:704-705. 2008. [PubMed]

  • Meet the Director

    Charles Rotimi

    Dr. Charles N. Rotimi is the Director of the Center for Research on Genomics and Global Health (CRGGH) and Chief and Senior Investigator in the Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch of the National Human Genome Research Institute, National Institutes of Health (NIH). His research activities have focused on identifying the genetic, social, and lifestyle determinants of diseases of major public health importance. He believes that studying diverse human populations is critically important in the global effort to use genomic tools to better understand human evolutionary history, and how this history may inform individual and group susceptibility/resistance to disease and variable response to drugs. To achieve these goals, Dr. Rotimi's lab has established major genetic epidemiology research projects in multiple ethnic groups in the United States, Africa (Nigeria, Ghana, Kenya, and Ethiopia) and China. The CRGGH was established to support and expand these global efforts.

    Overall, Dr. Rotimi believes that scientific activities operate within the larger context of society and that the junction of society and science has to be managed so as not to trample upon the independence required for good scholarly investigation or to alienate members of societies from the scientific process. In this regard, the CRGGH is interested in how scientists document and describe the nonrandom pattern of human genetic variation and its link to disease risks in different populations. For example, how does human genetic variation inform our understanding of self and group identity and differential distribution of diseases? Investigators at the CRGGH are directly involved in these debates and hope to inform the interpretation of human genetic variation within the context of health disparities and group identity.

    Dr. Rotimi received his undergraduate education in biochemistry from the University of Benin in Nigeria before immigrating to the United States for further studies. Dr. Rotimi started his education in the United States at the University of Mississippi where he obtained a Master's degree in Health Care Administration. He obtained a second Master's degree and a Doctorate in Epidemiology from the University of Alabama at Birmingham School of Public Health. Prior to coming to the NIH, Dr. Rotimi was the Director of the National Human Genome Center at Howard University. In his continued efforts to include the African community (both public and scientific), Dr. Rotimi provided leadership for the establishment of the African Society of Human Genetics and served as its president for 10 years.

    Read excerpts from an interview in The Lancet, October 2010 Vol. 376, #9750):

    Inequality is "one of the most outrageous aspects of society", says Charles Rotimi. That is why, earlier this year, he fulfilled "a lifetime achievement", with the launch of the Human Heredity and Health in Africa project (H3Africa), an international partnership to support population-based genetic studies on that continent. For Rotimi, understanding human genetic variation through genomics is important in global efforts to reduce health disparities, and these endeavours must "ensure all human populations are engaged in the use of genomics to solve societal problems from hunger to health".

    Rotimi "has demonstrated unequivocally that 'because it had not been done before' was no excuse for not including Africa and the African diaspora in the human genome revolution", comments Georgia Dunston, founding and acting Director of the National Human Genome Center (NHGC) at Howard University, Washington, DC. Rotimi is concerned to involve Africans in genetic epidemiology, both as participants and researchers. "There is only one human race", Rotimi says. "One common characteristic of humans is that we like to travel and to share our genetic inheritance and with each such interaction we change the genetic attributes of human populations." Thus, a comprehensive understanding of population and ethnic differences requires a robust appreciation of human history: "At a fundamental level", he says, "we are all Africans beneath our skin."

    What Rotimi does not study is race. "If we look at pharmacogenomics and social groups — Africans, black, white, Hispanic, and so on — it's pretty clear that at the level of drug metabolising enzymes, genes don't align themselves in a consistent manner with social labels". Members of the same family or ethnic group, for example, may carry different copies of important drug metabolising enzymes, and similar observations are true for genes important for human diseases. So, Rotimi explains, the classification of research populations "should be driven by the questions we want to answer". Continental origin is important, for example, when variations have been driven by historical environmental differences, such as climate, farming practices, and diet. Consideration of ethnic groups "gives us flexibility to account for the dynamic nature of both inherited and cultural characteristics", says Rotimi. Thus, he advocates ethnic labelling of study populations because "it captures the dynamic nature of human relationships that 'race' does not allow — 'race' connotes fixed boundaries — one pure group", he says.

    You can also read Dr. Rotimi's interview in Nature Genetics as he answers questions on the role genomics plays in eliminating and addressing health disparities. (Note: the CRGGH was initially referred to as the NIH Intramural Center for Genomics and Health Disparities): Rotimi C. Straight talk with... Charles Rotimi. Interview by Charlotte Schubert. Nat Med, 14:704-705. 2008. [PubMed]

CRGGH Staff

Adebowale Adeyemo
Adebowale A. Adeyemo, M.D.
  • Deputy Director
  • Center for Research on Genomics and Global Health
Amy Bentley
Amy R. Bentley, Ph.D.
  • Staff Scientist
  • Center for Research on Genomics and Global Health
Guanjie Chen
Guanjie Chen, M.D.
  • Senior Research Fellow
  • Center for Research on Genomics and Global Health
Ayo Doumatey
Ayo P. Doumatey, Ph.D.
  • Staff Scientist
  • Center for Research on Genomics and Global Health
Shirley Freeman
Shirley T. Freeman, B.S.
  • Program Assistant
  • Center for Research on Genomics and Global Health
Lin Lei
Lin Lei
  • Biochemist
  • Center for Research on Genomics and Global Health
Daniel Shriner
Daniel N. Shriner, Ph.D.
  • Staff Scientist
  • Center for Research on Genomics and Global Health
Jie Zhou
Jie Zhou
  • Data Manager
  • Center for Research on Genomics and Global Health
Shawneequa Callier
Shawneequa L. Callier, M.A., J.D.
  • Special Volunteer
  • Center for Genomics and Global Health

Trainees

Over the years, Dr. Rotimi has provided a wonderful environment for the training of several minority scientists and students from high school through graduate programs and beyond in biomedical research. As the Director of the CRGGH, he will continue to provide training opportunities and with support and collaboration from various NIH institutes, investigators at the center will continue to develop a more robust training program to encourage and engage U.S. minority and international students and faculty in genomics and human genetic variation research.

Current Trainees

Kenneth Ekoru, Ph.D.
Postdoctoral Fellow
Building 12A, Room 4047
12 South Dr., MSC 5635
Bethesda, MD 20892-5635
Phone: 301-435-0137
Fax: 301-451-5426
Email: kenneth.ekoru@nih.gov

Mateus Gouveia, Ph.D.
Postdoctoral Fellow
Building 12A, Room 4044
12 South Dr., MSC 5635
Bethesda, MD 20892-5635
Phone: 301-827-7198
Fax: 301-451-5426
Email: mateus.gouveia@nih.gov
 
Karlijn Meeks, Ph.D.
Postdoctoral Fellow
Building 12A, Room 4044
12 South Dr., MSC 5635
Bethesda, MD 20892-5635
Phone: 301-827-7197
Fax: 301-451-5426
Email: karlijn.meeks@nih.gov

Former Trainees
Name Years Active
Chang Liu, Ph.D. 2018-2019
Sally Adebamowo, M.D., Sc.D. 2015-2016
Jennifer Baker, Ph.D. 2015-2016
Fasil Tekola-Ayele, Ph.D. 2008-2016
Karlijn Meeks 2015
Ephrem Mekonnen Gebeyehu 2014
Debbie Barrington, Ph.D., M.P.H. 2011-2013
Rhea Wyse 2011
Huichun Xu, M.D., Ph.D. 2010-2013
Emmanuel Peprah, Ph.D. 2010-2012
Ephrem Teklemariam 2010-2011
Bashira A. Charles, Ph.D. 2009-2014
Shantelle Lucas, Ph.D. 2009-2011
Keolu Fox 2009-2010
Edward Ramos, Ph.D. 2008-2013
Katherine Meilleur, Ph.D. 2008-2010
  • Trainees

    Over the years, Dr. Rotimi has provided a wonderful environment for the training of several minority scientists and students from high school through graduate programs and beyond in biomedical research. As the Director of the CRGGH, he will continue to provide training opportunities and with support and collaboration from various NIH institutes, investigators at the center will continue to develop a more robust training program to encourage and engage U.S. minority and international students and faculty in genomics and human genetic variation research.

    Current Trainees

    Kenneth Ekoru, Ph.D.
    Postdoctoral Fellow
    Building 12A, Room 4047
    12 South Dr., MSC 5635
    Bethesda, MD 20892-5635
    Phone: 301-435-0137
    Fax: 301-451-5426
    Email: kenneth.ekoru@nih.gov

    Mateus Gouveia, Ph.D.
    Postdoctoral Fellow
    Building 12A, Room 4044
    12 South Dr., MSC 5635
    Bethesda, MD 20892-5635
    Phone: 301-827-7198
    Fax: 301-451-5426
    Email: mateus.gouveia@nih.gov
     
    Karlijn Meeks, Ph.D.
    Postdoctoral Fellow
    Building 12A, Room 4044
    12 South Dr., MSC 5635
    Bethesda, MD 20892-5635
    Phone: 301-827-7197
    Fax: 301-451-5426
    Email: karlijn.meeks@nih.gov

    Former Trainees
    Name Years Active
    Chang Liu, Ph.D. 2018-2019
    Sally Adebamowo, M.D., Sc.D. 2015-2016
    Jennifer Baker, Ph.D. 2015-2016
    Fasil Tekola-Ayele, Ph.D. 2008-2016
    Karlijn Meeks 2015
    Ephrem Mekonnen Gebeyehu 2014
    Debbie Barrington, Ph.D., M.P.H. 2011-2013
    Rhea Wyse 2011
    Huichun Xu, M.D., Ph.D. 2010-2013
    Emmanuel Peprah, Ph.D. 2010-2012
    Ephrem Teklemariam 2010-2011
    Bashira A. Charles, Ph.D. 2009-2014
    Shantelle Lucas, Ph.D. 2009-2011
    Keolu Fox 2009-2010
    Edward Ramos, Ph.D. 2008-2013
    Katherine Meilleur, Ph.D. 2008-2010

Working Group

Wylie Burke, M.D., Ph.D. (Chair)
Professor and Chair, Department of Bioethics and Humanities
University of Washington

Francisco E. Baralle, M.D., Ph.D.
Director-General, International Centre for Genetic Engineering and Biotechnology

Carlos D. Bustamante, Ph.D.
Professor, Genetics
Member, Bio-X

Mary-Claire King, Ph.D.
American Cancer Society Professor
Depts. of Medicine (Medical Genetics) and Genome Sciences Health Sciences

Deborah Nickerson, Ph.D.
Professor of Genome Sciences
Adjunct Professor of Bioengineering
University of Washington

Himla Soodyall, Ph.D.
Director, Human Genomic Diversity and Disease Research Unit (HGDDRU)
National Health Laboratory Service and University of the Witwatersrand

David R. Williams, M.P.H., Ph.D.
Florence & Laura Norman Professor of Public Health Professor of African and African American Studies and of Sociology
Staff Director, RWJF Commission to Build a Healthier America Department of Society, Human Development and Health Harvard School of Public Health

  • Working Group

    Wylie Burke, M.D., Ph.D. (Chair)
    Professor and Chair, Department of Bioethics and Humanities
    University of Washington

    Francisco E. Baralle, M.D., Ph.D.
    Director-General, International Centre for Genetic Engineering and Biotechnology

    Carlos D. Bustamante, Ph.D.
    Professor, Genetics
    Member, Bio-X

    Mary-Claire King, Ph.D.
    American Cancer Society Professor
    Depts. of Medicine (Medical Genetics) and Genome Sciences Health Sciences

    Deborah Nickerson, Ph.D.
    Professor of Genome Sciences
    Adjunct Professor of Bioengineering
    University of Washington

    Himla Soodyall, Ph.D.
    Director, Human Genomic Diversity and Disease Research Unit (HGDDRU)
    National Health Laboratory Service and University of the Witwatersrand

    David R. Williams, M.P.H., Ph.D.
    Florence & Laura Norman Professor of Public Health Professor of African and African American Studies and of Sociology
    Staff Director, RWJF Commission to Build a Healthier America Department of Society, Human Development and Health Harvard School of Public Health

Last updated: July 30, 2019