When it comes to Attention-Deficit/Hyperactivity Disorder (ADHD), genetics do make an impact, but it is not easily pinned down. Many common but subtle differences in our DNA come together to have a huge influence on creating one of ADHD's cardinal symptoms: hyperactivity-impulsivity. In a study published in the January 30 issue of Molecular Psychiatry, NHGRI researchers examined people with ADHD to map brain connections, called white matter tracts, tied to the disorder.
Most pregnant women want doctors' advice on the types of information to receive from prenatal whole genome sequencing. Obstetricians and other clinicians will need additional training on how to present fetal genomic information in a way that meets an individual woman's needs.
Researchers with the National Institutes of Health Undiagnosed Disease Program have developed a powerful new toolset for finding potential disease-causing gene variants in undiagnosed patients. The work is automatically accomplished by computers - with no human interpretation or bias - and takes about three hours per exome, an individual's protein-coding genes.