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Research at NHGRI

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An Overview

Division of Intramural Research mission, vision and values
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Descriptions for the nine research branches of the Division of Intramural Research
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Research Investigators

Profiles of NHGRI scientists, their research and current publications
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Clinical Research

NHGRI's clinical research program, the Undiagnosed Diseases Program and current clinical studies

NHGRI Affiliated Centers

Collaborations with other NIH centers involved in genomic research
Letters A-C-T-G

Online Research Resources

Databases, software and research tools developed by NHGRI researchers
Paper Calendar

Intramural Calendar

Intramural research workshops, conferences, seminar series and courses
Books (Hard Copies)

Publications, Books, and Resources

Current publications for intramural research scientists
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Organizational Chart

Organization and personnel for the Division of Intramural Research


NIH study reveals how melanoma spreads

MelanomaNewly identified genes and genetic pathways in primary melanoma - a type of skin cancer - could give researchers new targets for developing new personalized treatments for melanoma, and potentially other cancers. Learning how the genes are expressed - turned on or off - could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow. Read the study in the February 6, 2017, online issue of Pigment Cell and Melanoma Research

Findings: Induced pluripotent stem cells don't increase genetic mutations 

Pluripotent stem cellsDespite immense promise, adoption of induced pluripotent stem cells (iPSCs) in biomedical research and medicine has been slowed by concerns that these cells are prone to increased numbers of genetic mutations. A new study by NHGRI scientists suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning. Read the study in the early edition of The Proeedings of the National Academy of Sciences for February 6, 2017. 

Research provides more insight into genetic basis of Behçet's disease

Health Disparities and the MicrobiomeBehçet's disease is a disease that destroys blood vessels through systemic inflammation, manifesting as painful oral and genital ulcers, as well as vision destroying inflammation of the eyes. Research suggests the disease develops due to pathogen exposure, along with a mix of genetic and environmental risk factors, but their interaction is poorly understood. The study appears in the February 6, 2017 online version of Nature Genetics.

Health disparities research focused on the microbiome requires the collaboration of many disciplines

Health Disparities and the MicrobiomeNHGRI researchers and their colleagues are calling for health disparities research that focuses on the microbiome. Health disparities -- the negative health outcomes that impact certain groups of people - and the microbiome - the microorganisms that live in and on us -- are both influenced by people's environments and social interactions. As a result, the microbiome and health differences experienced by diverse people may be a two-way street, with the biological and environmental factors influencing each other, according to the perspective published in the journal Trends in Microbiology.