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NIH

Research at NHGRI

The Division of Intramural Research conducts a broad program of laboratory and clinical research

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An Overview

Division of Intramural Research mission, vision and values
Buildings on NIH Main Campus

Branches

Descriptions for the nine research branches of the Division of Intramural Research
Dan Kastner

Research Investigators

Profiles of NHGRI scientists, their research and current publications
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Clinical Research

NHGRI's clinical research program, the Undiagnosed Diseases Program and current clinical studies

NHGRI Affiliated Centers

Collaborations with other NIH centers involved in genomic research
Letters A-C-T-G

Online Research Resources

Databases, software and research tools developed by NHGRI researchers
Paper Calendar

Intramural Calendar

Intramural research workshops, conferences, seminar series and courses
Books (Hard Copies)

Publications, Books, and Resources

Current publications for intramural research scientists
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Organizational Chart

Organization and personnel for the Division of Intramural Research

Highlights

NHGRI joins international team to sequence Mongolian genomes

Mongolian GenomesNorth Asians, including Mongolians and other Siberian ethnic groups, may be more closely related to Eastern and Northern Europeans - including the people of Finland -- than previously thought, according to a new genomics study inĀ Nature Genetics. The international team of researchers, including those from the National Human Genome Research Institute (NHGRI), made the connection by comparing the whole-genome sequences of 175 ethnic Mongolians to existing genetic variation data.

Systematic review study supports that sickle cell trait increases risk for some health conditions

Sickle cellIn the United States, an estimated 2.5 to 3 million people have a gene variant associated sickle cell trait (SCT) and most never have related health complications. Researchers have now identified three health conditions for which people with SCT are at increased risk. They include pulmonary embolism, proteinuria and chronic kidney disease. Findings from this first comprehensive review of clinical outcomes associated with SCT were published in the October 30, 2018, issue of the Annals of Internal Medicine.

New technique promising for a more accurate genome sequence

CowsResearchers at the National Institutes of Health (NIH) and the United States Department of Agriculture (USDA) have developed a new technique that will aid in a more accurate reconstruction of genomes, specifically in determining the sections of the genome that come from each parent. This new technique, published in the journal Nature Biotechnology, will allow researchers to identify further complexity within any type of genome - from plants to humans - and provide more precise reference genomes in researcher databases than are currently available.