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Research at NHGRI

The Division of Intramural Research conducts a broad program of laboratory and clinical research

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An Overview

Division of Intramural Research mission, vision and values
Buildings on NIH Main Campus


Descriptions for the nine research branches of the Division of Intramural Research
Dan Kastner

Research Investigators

Profiles of NHGRI scientists, their research and current publications
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Clinical Research

NHGRI's clinical research program, the Undiagnosed Diseases Program and current clinical studies

NHGRI Affiliated Centers

Collaborations with other NIH centers involved in genomic research
Letters A-C-T-G

Online Research Resources

Databases, software and research tools developed by NHGRI researchers
Paper Calendar

Intramural Calendar

Intramural research workshops, conferences, seminar series and courses
Books (Hard Copies)

Publications, Books, and Resources

Current publications for intramural research scientists
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Organizational Chart

Organization and personnel for the Division of Intramural Research


The 2018 Jeffrey M. Trent Lectureship in Cancer Research

Hospital CorridorThe National Human Genome Research Institute's Division of Intramural Research presented the 14th Jeffrey M. Trent Lecture in Cancer Research on March 15, 2018, 12:00 - 1:00 p.m., at the Lipsett Amphitheater, Building 10 (Clinical Center), on the National Institutes of Health (NIH) Bethesda campus. Joan Brugge, Ph.D., co-director, Ludwig Center at Harvard Medical School, delivered the lecture Role of the TRPA1 Ca2+-permeable Channel in Oxidative Stress Defenses in Cancer. Video is now available.

Researchers pinpoint origin of sickle cell mutation

Sickle Cell NHGRI researchers used whole genome sequence data to pinpoint the single origin of the sickle cell mutation to the "wet" period of the Sahara 7,300 years ago. The mutation causes blood hemoglobin to be crescent shaped, reducing its ability to carry oxygen. Charles N. Rotimi, Ph.D., study co-author and NHGRI senior investigator, said the finding overturns previous theories that the cell mutation arose in multiple locations. This will help clinicians redefine sickle cell subgroups and treat patients more effectively, said lead author Daniel Shriner, Ph.D. Read more in the March 8 American Journal of Human Genetics.

NIH researchers highlight virtual reality research on Reddit

Susan PerskyVirtual Reality (VR) is a rapidly expanding area in tech and gaming. Now it's also playing an important role in medicine and health, expanding opportunities for researchers, clinicians and patients. Simulated experience can reduce stress, help doctors practice surgical techniques or allow medical students a way to practice their bedside manner in virtual scenarios. On February 23, NHGRI hosted a Reddit "Ask Me Anything" (AMA) with NIH researchers who use VR to study a host of research questions. Read our recap here.

NIH pilot project will match researchers to genes, gene variants of interest

TGACThe National Institutes of Health and Inova have launched a new match-making service between genes and gene variants and the researchers who study them. The Genomic Ascertainment Cohort (TGAC) project will be based in the Washington, D.C., area so that researchers can recall genotyped participants to examine the genes and gene variants that influence their phenotype.