The National Human Genome Research Institute's Division of Intramural Research presented the 14th Jeffrey M. Trent Lecture in Cancer Research on March 15, 2018, 12:00 - 1:00 p.m., at the Lipsett Amphitheater, Building 10 (Clinical Center), on the National Institutes of Health (NIH) Bethesda campus. Joan Brugge, Ph.D., co-director, Ludwig Center at Harvard Medical School, delivered the lecture Role of the TRPA1 Ca2+-permeable Channel in Oxidative Stress Defenses in Cancer. Video is now available.
NHGRI researchers used whole genome sequence data to pinpoint the single origin of the sickle cell mutation to the "wet" period of the Sahara 7,300 years ago. The mutation causes blood hemoglobin to be crescent shaped, reducing its ability to carry oxygen. Charles N. Rotimi, Ph.D., study co-author and NHGRI senior investigator, said the finding overturns previous theories that the cell mutation arose in multiple locations. This will help clinicians redefine sickle cell subgroups and treat patients more effectively, said lead author Daniel Shriner, Ph.D. Read more in the March 8 American Journal of Human Genetics.
Virtual Reality (VR) is a rapidly expanding area in tech and gaming. Now it's also playing an important role in medicine and health, expanding opportunities for researchers, clinicians and patients. Simulated experience can reduce stress, help doctors practice surgical techniques or allow medical students a way to practice their bedside manner in virtual scenarios. On February 23, NHGRI hosted a Reddit "Ask Me Anything" (AMA) with NIH researchers who use VR to study a host of research questions. Read our recap here.
The National Institutes of Health and Inova have launched a new match-making service between genes and gene variants and the researchers who study them. The Genomic Ascertainment Cohort (TGAC) project will be based in the Washington, D.C., area so that researchers can recall genotyped participants to examine the genes and gene variants that influence their phenotype.