The National Human Genome Research Institute is the driving force for advancing genomics research at the National Institutes of Health, the largest biomedical research agency in the world. Our institute's history is inextricably intertwined with the Human Genome Project and the history of the field of genomics.
The National Human Genome Research Institute began as the National Center for Human Genome Research (NCHGR), which was established in 1989 to carry out the role of the National Institutes of Health (NIH) in the International Human Genome Project (HGP). The HGP was developed in collaboration with the United States Department of Energy and begun in 1990 to map the human genome.
In 1993, NCHGR expanded its role on the NIH campus by establishing the Division of Intramural Research to apply genome technologies to the study of specific diseases. In 1996, the Center for Inherited Disease Research (CIDR) was also established (co-funded by eight NIH institutes and centers) to study the genetic components of complex disorders.
In 1997 the United States Department of Health and Human Services renamed NCHGR the National Human Genome Research Institute (NHGRI), officially elevating it to the status of research institute - one of 27 institutes and centers that make up the NIH. Now, with the human genome sequence complete since April 2003, scientists around the world have access to a database that greatly facilitates and accelerates the pace of biomedical research.
February 29-March 1, 1988: National Institutes of Health Director James Wyngaarden assembles scientists, administrators and science policy experts in Reston, Va., to lay out a plan for the Human Genome Project.
August 15, 1988: A program advisory committee on the human genome is established to advise the National Institutes of Health on all aspects of research in the area of genomic analysis.
October 1, 1988: The Office for Human Genome Research is created within the Office of the Director, National Institutes of Health. Also, NIH and the Department of Energy sign a memorandum of understanding to "coordinate research and technical activities related to the human genome."
January 3-4, 1989: The program advisory committee on the human genome holds its first meeting in Bethesda, Md.
October 1, 1989: The National Center for Human Genome Research is established to carry out the National Institutes of Health's component of the United States Human Genome Project. The center's first director is James D. Watson**, co-discoverer with Francis Crick of the double-helical structure of DNA.
April 1990: A five-year plan with specific goals for the project is published.
May 8, 1990: The National Advisory Council for Human Genome Research is established.
July 1, 1990: The Genome Research Review Committee is created so the National Center for Human Genome Research can conduct appropriate peer review of human genome grant applications.
October 1, 1990: The Human Genome Project officially begins.
January 22, 1991: The National Advisory Council for Human Genome Research meets for the first time in Bethesda, MD.
April 10, 1992: James Watson** resigns as first director of the National Center for Human Genome Research. Michael Gottesman is appointed acting NCHGR director.
February 1993: The Division of Intramural Research within the National Center for Human Genome Research is established.
April 4, 1993: Francis S. Collins, M.D., Ph.D. is appointed director of the National Center for Human Genome Research.
October 1, 1993: The United States Human Genome Project revises its five-year goals through September 1998.
September 30, 1994: Human genetic mapping goal achieved one year ahead of schedule.
November 15, 1995: National Center for Human Genome Research celebrates its 5th anniversary. James D. Watson** Lecture is established.
April 1995: The Task Force on Genetic Testing is established as a subgroup of the National Institutes of Health (NIH)/Department of Energy Ethical, Legal and Social Implications Working Group.
April 11, 1996: Human DNA sequencing begins with pilot studies at six universities in the United States.
April 24, 1996: An international team completes the DNA sequence of the first eukaryotic genome, Saccharomyces cerevisiae, or common brewer's yeast.
September 1996: The Center for Inherited Disease Research [cidr.jhmi.edu] (CIDR), a project co-funded by eight National Institutes of Health (NIH) institutes and centers to study the genetic components of complex disorders, is established on the Johns Hopkins Bayview Medical Center campus in Baltimore.
October 1996: Scientists from government, university and commercial laboratories around the world reveal a map that pinpoints the locations of over 16,000 genes in human DNA.
November 1996: National Center for Human Genome Research and other researchers identify the location of the first gene associated with Parkinson's disease.
November 1996: National Center for Human Genome Research and other researchers identify the location of the first major gene that predisposes men to prostate cancer.
December 1996: ELSI Report is issued by the Joint National Institutes of Health/Department of Energy Committee evaluating the Ethical, Legal and Social Imlications program of the Human Genome Project.
January 1997: Department of Health and Human Services Secretary Donna E. Shalala signs documents giving National Center for Human Genome Research a new name and new "status" among other research institutes at the National Institutes of Health. The new name, the National Human Genome Research Institute, more accurately reflects its growth and accomplishments. As an institute, NHGRI can more appropriately interact with other federal agencies and share equal standing with other institutes at NIH.
March 1997: A government-citizen group suggests policies to limit genetic discrimination in the workplace.
May 1997: The National Human Genome Research Institute and other scientists show that three specific alterations in the breast cancer genes BRCA1 and BRCA2 are associated with an increased risk of breast, ovarian and prostate cancers.
June 1997: The National Human Genome Research Institute scientists precisely identify a gene abnormality that causes some cases of Parkinson's disease.
July 1997: A map of human chromosome 7 is completed.
December 1997: The National Human Genome Research Institute and other researchers identify an altered gene that causes Pendred Syndrome, a inherited form of deafness.
March 1998: Vice President Al Gore announces that the Clinton administration is calling for legislation to bar employers from discriminating against workers in hiring or promotion because of their genetic makeup.
September 1998: At a meeting of the main advisory body for the Human Genome Project (HGP), project planners present a new plan to produce a "finished" version of the DNA sequence of the human genome by the end of 2003, two years ahead of its original schedule. The HGP plans to generate a "working draft" in 2001 that, together with the finished sequence, will cover at least 90 percent of the genome. The working draft will be immediately valuable to researchers and will form the basis for a high-quality, finished genome sequence.
September 1998: A major international collaborative research study finds the site of a gene for susceptibility to prostate cancer on the X chromosome. This is the first time a gene for a common type of cancer is mapped to the X chromosome.
October 1998: The National Institutes of Health and the Department of Energy develop a new five-year plan for the Human Genome Project. This plan, published in the October 23 issue of the journal Science [scienceonline.org], is designed to carry the project forward for the next five years, fiscal years 1999 through 2003.
December 1998: The genome of the tiny roundworm (Caenorhabditis elegans) is sequenced by researchers from the National Human Genome Research Institute (NHGRI) and other Human Genome Project (HGP)-funded scientists.
March 1999: Large-scale sequencing of the human genome begins.
September 1999: Human Genome Project scientists confirm they are on schedule to produce the working draft of the genetic blueprint of humankind by Spring 2000.
October 1999: President Clinton and First Lady Hillary Rodham Clinton host the eighth Millennium Evening at the White House. The program is titled "Informatics Meets Genomics."
November 12, 1999: The National Human Genome Research Institute (NHGRI) hosts the first annual "Consumer Day" conference to inform patients, families and health care providers about the impact of the Human Genome Project.
November 1999: The National Human Genome Research Institute, Department of Energy and the Wellcome Trust hold a celebration of the completion and deposition into GenBank of one billion base pairs of the human genome DNA sequence.
December 1999: The National Human Genome Research Institute (NHGRI) and other Human Genome Project (HGP)-funded scientists unravel for the first time the genetic code of an entire human chromosome. The findings are reported in the December 2 issue of Nature [nature.com].
February 2000: President Clinton signs Executive Order to prevent genetic discrimination in any federal workplace.
March 2000: A public consortium of scientists and a private company release a substantially complete genome sequence of the fruitfly (Drosophila melanogaster). The findings are reported in the March 24 issue of Science.
April 3-6, 2000: The National Human Genome Research Institute (NHGRI), the National Institutes of Health (NIH) Office of Rare Disease Research, and the Don and Linda Carter Foundation sponsor the first NIH Conference on Holoprosencephaly.
May 2000: Scientists in Japan and Germany report in the May 18 issue of Nature [nature.com] that they have unraveled the genetic code of human chromosome 21, already known to be involved with Down syndrome, Alzheimer's disease, Usher syndrome and Lou Gehrig's disease.
June 2000: The Human Genome Project consortium announces a major milestone: It has assembled 85 percent of the sequence of the human genome - the genetic blueprint for a human being. See White House Announcement
August 2000: Scientists discover a genetic "signature" that may help explain how malignant melanoma - a deadly form of skin cancer - can spread to other parts of the body. Findings are reported in the August 3 issue of Nature.
October 2000: The National Institutes of Health, the Wellcome Trust, and three private companies collaborate to form the Mouse Genome Sequencing Consortium (MGSC) to accelerate the determination of the DNA sequence of the mouse genome.
October 2000: The Human Genome Project is the recipient of the American Society of Human Genetics' Allan Award to honor the hundreds of scientists involved in deciphering the human genetic code.
November 9, 2000: The National Human Genome Research Institute (NHGRI) hosts the second annual "Consumer Day.
January 16-18, 2001: The Ethical, Legal and Social Implications (ELSI) Research Programs of The National Human Genome Research Institute and the Department of Energy sponsor a conference to celebrate a decade of research and consider its impact on genetic research, health and policy.
February 2001: The International Human Genome Sequencing Consortium publishes a series of scientific papers in the February 15 issue of Nature [nature.com], providing the first analysis of the human genome sequence that describes how it is organized and how it evolved. One significant discovery reveals that there are only 30,000 to 40,000 genes, not 100,000 as previously thought.
February 2001: National Human Genome Research Institute scientists use microarray technology to develop a gene test that differentiates hereditary from sporadic types of breast cancer. Findings are reported in the February 22 issue of The New England Journal of Medicine [nejm.org].
March 2001: National Human Genome Research Institute and Human Genome Project-funded scientists find a new tumor suppressor gene involved in breast, prostate and other cancers on human chromosome 7. A single post-doc, using the "working draft" sequence data, is able to pin down the gene within weeks; before, the same work took several years and the work of many scientists. Findings are reported in the April issue of Nature Genetics [nature.com].
May 2001: The Mouse Genome Sequencing Consortium announces it has achieved three-fold coverage of the mouse DNA sequence. The data, representing 95 percent of the mouse sequence, are publicly available [ncbi.nlm.nih.gov] and will be an important tool for discovering human genes when comparing the genomes of the mouse and human.
May 2001: The National Human Genome Research Institute and scientists at Sweden's Lund University develop a method of accurately diagnosing four complex, hard-to-distinguish childhood cancers using microarray technology and artificial neural networks (ANN). Findings are published in the June issue of Nature [nature.com].
September 2001: The National Human Genome Research Institute announces the first Centers of Excellence in Genomic Science Award, a research program that supports multi-investigator, interdisciplinary teams who develop innovative genomic approaches that address important biological and biomedical research problems and seek to change the way genomics is done and used in biomedicine.
November 9-11, 2001: The National Human Genome Research Institute co-sponsors The Human Genome Project Conference: The Challenges and Impact of Human Genome Research for Minority Communities, with the Zeta Phi Beta Sorority National Education Foundation, the National Human Genome Center at Howard University, and the Family Life Center Foundation at Shiloh Baptist Church.
December 12-14, 2001: The National Human Genome Research Institute holds the planning conference, Beyond the Beginning: The Future of Genomics at the Airlie Conference Center in Warrenton, Virginia, to develop a broad vision of the future of genomics research that will lay the foundation for a bold new plan for NHGRI.
January 2002: The National Human Genome Research Institute and other scientists find a gene on chromosome 1 associated with an inherited form of prostate cancer in some families. The findings are published in the February issue of Nature Genetics [nature.com].
February 2002: The National Human Genome Research Institute and the NIH Office of Rare Diseases launch the Genetics and Rare Diseases Information Center, delivering free and accurate information to patients and their families about genetic and rare diseases.
May 2002: The Mouse Genome Sequencing Consortium announces a 96 percent complete working draft of the mouse genome freely available in public databases [ensembl.org]. The methods to sequence the mouse genome set a new standard for speed and accuracy.
September 2002: Alan Edward Guttmacher, M.D. is named as the second deputy director of the National Human Genome Research Institute (NHGRI). Vence L. Bonham, Jr., J.D., is appointed as NHGRI's Senior Consultant to the Director on Health Disparities.
September 2002: Gene discovery by an international team of researchers led by the National Human Genome Research Institute, reveals the cause for a rare form of microcephaly, a devastating brain disorder.
October 2002: The National Human Genome Research Institute launches the International HapMap Project, this new venture is aimed at speeding the discovery of genes related to common illnesses such as asthma, cancer, diabetes and heart disease.
October 2002: The National Human Genome Research Institute, in cooperation with five other institutes and centers at the National Institutes of Health, awards a three-year, $15-million grant to combine three of the world's current protein sequence databases into a single global resource.
November 2002: The National Human Genome Research Institute selects Eric D. Green, M.D., Ph.D., as the new scientific director for the NHGRI.
November 2002: The National Human Genome Research Institute names William A. Gahl, M.D., Ph.D., as its new intramural clinical director.
December 2002: The international Mouse Genome Sequencing Consortium announces the publication of a high-quality draft sequence of the mouse genome - the genetic blueprint of a mouse.
February 2003: The National Human Genome Research Institute and the Department of Energy announce April 2003 events to celebrate the 50th anniversary of the discovery of the DNA double helix, the completion of the human genome sequence and the publication of the vision plan for NHGRI.
March 2003: The National Human Genome Research Institute announces a new project - the ENCODE Project - with the long-term goal of creating a comprehensive encyclopedia of functional elements encoded in the human DNA.
April 2003: The National Human Genome Research Institute celebrates the completion of the human genome sequence, the 50th anniversary of the description of the DNA double helix and the publication of the vision document for the future of genomics research.
April 2003: National Human Genome Research Institute researchers identify the gene that causes the premature aging disorder progeria. The findings were released online in the journal Nature [nature.com].
June 2003: A detailed analysis of the just-completed sequence of the human Y chromosome - a study published in the June issue of Nature [nature.com], and funded in large part by the National Human Genome Research Institute (NHGRI) - shows the Y chromosome appears to exchange genes between the two copies of repeated sequences that lie near to each other as mirror images.
July 2003: A detailed analysis of the reference sequence of chromosome 7, carried out by a multinational team of scientists led by the Washington University School of Medicine, uncovers structural features that appear to promote genetic changes that can cause disease. The findings were reported in the July 10 issue of the journal Nature [nature.com]. National Human Genome Research Institute (NHGRI) Scientific Director Eric Green co-authored the study.
August 2003: A team of researchers led by the National Human Genome Research Institute reports findings on the comparison of 13 vertebrate genomes. Results, published in the August 14 issue of Nature [nature.com], suggested that comparison of a wide variety of species' genomes will not only illuminate genomic evolution but help identify functional elements in the human genome.
October 2003: The National Human Genome Research Institute announced the first grants in a three-year, $36 million scientific reconnaissance mission - called ENCODE - aimed at discovering all parts of the human genome that are crucial to biological function.
October 14, 2003: The U.S. Senate passes the Genetic Information Nondiscrimination Act of 2003 (S. 1053) [thomas.loc.gov] by a vote of 95-0, the first time the Senate has passed a bipartisan, genetic nondiscrimination bill. The bill prevents health insurers and employers from using genetic information to determine eligibility, set premiums, or hire and fire people. The bill faces approval in the House of Representatives and from the President.
November 7, 2003: The National Human Genome Research Institute announces the selection of five centers to carry out a new generation of large-scale sequencing projects designed to maximize the promise of the Human Genome Project and dramatically expand our understanding of human health and disease.
December 5, 2003: The National Human Genome Research Institute announces the formation of a new branch - the Social and Behavioral Research Branch - within its Division of Intramural Research.
December 10, 2003: The National Human Genome Research Institute announces the first draft version of the chimpanzee genome sequence and its alignment with the human genome.
December 17, 2003: The International HapMap Consortium publishes a paper that sets forth the scientific rationale and strategybehind its effort to create a map of human genetic variation.
January 7, 2004: The National Human Genome Research Institute announces that the first draft version of the honey bee genome sequence has been deposited into free public databases.
January 26, 2004: The National Human Genome Research Institute and other scientists successfully create transgenic animals using sperm genetically modified and grown in a laboratory dish, an achievement with implications for wide ranging research, from developmental biology to gene therapy. The study [pnas.org] was published in the online edition of the Proceedings of the National Academy of Sciences.
February 3, 2004: The Genetic and Rare Diseases Information Center established by the National Human Genome Research Institute and NIH Office of Rare Diseases, announces it has expanded its efforts to enable healthcare workers, patients and families who speak Spanish to take advantage of its free services.
February 25, 2004: The National Human Genome Research Institute's Large-Scale Sequencing Research Network announces it will begin sequencing the genome of the first marsupial, the gray short-tailed South American opossum, and more than a dozen other model organisms to further advance our understanding of the human genome.
March 1, 2004: The National Human Genome Research Institute announces that the first draft version of the chicken genome sequence has been deposited into free public databases.
March 11, 2004: National Human Genome Research Institute and other scientists find variants in a gene that may predispose people to type 2 diabetes, the most common form of the disease.
March 24, 2004: The National Human Genome Research Institute announces that the International Sequencing Consortium has launched a free online resource, where scientists and the public can view the latest information on sequencing projects for animal, plant and eukaryotic genomes.
March 31, 2004: The International Rat Genome Sequencing Project Consortium announces the publication of a high-quality draft sequence of the rat genome.
June 8, 2004: The National Human Genome Research Institute and the Melbourne-based Australian Genome Research Facility, Ltd. announce a partnership to sequence the genome of the tammar wallaby, a member of the kangaroo family.
June 28, 2004: The National Human Genome Research Institute announces it has established two new Centers of Excellence in Genomic Science (CEGS) at Harvard Medical School in Boston and the Johns Hopkins University School of Medicine in Baltimore.
July 14, 2004: The National Human Genome Research Institute announces that the first draft version of the dog genome sequence has been deposited into free public databases.
July 19, 2004: The National Human Genome Research Institute launches the NHGRI Policy and Legislative Database, an online resource that will enable researchers, health professionals and the general public to more easily locate information on laws and policies related to a wide array of genetic issues
July 26, 2004: National Human Genome Research Institute scientists and an interdisciplinary consortium of researchers from 11 universities and institutions discover a possible inherited component for lung cancer, a disease normally associated with external causes, such as cigarette smoking.
August 4, 2004: The National Human Genome Research Institute's Large-Scale Sequencing Research Network announces a comprehensive strategic plan to sequence 18 additional organisms, including the African savannah elephant, domestic cat and orangutan, to help interpret the human genome.
August 31, 2004: The National Human Genome Research Institute launches four interdisciplinary Centers for Excellence in Ethical, Legal and Social Implications Research to address some of the most pressing ethical, legal and social questions raised by recent advances in genetic and genomic research.
October 6, 2004: The National Human Genome Research Institute announces that the first draft version of the bovine genome sequence has been deposited into free public databases.
October 14, 2004: The National Human Genome Research Institute awards more than $38 million in grants to develop new sequencing technologies to accomplish the near-term goal of sequencing a mammalian-sized genome for $100,000 and the longer-term challenge of sequencing an individual human genome for $1,000 or less.
October 18, 2004: The National Human Genome Research Institute announces that two of its medical geneticists, Dr. Alan Guttmacher and Dr. Robert Nussbaum, are elected to the Institute of Medicine of the National Academies.
October 21, 2004: The International Human Genome Sequencing Consortium, led in the United States by the National Human Genome Research Institute and the Department of Energy (DOE) publishes its scientific description of the finished human genome sequence, reducing the estimated number of human protein-coding genes from 35,000 to only 20,000-25,000, a surprisingly low number for our species.
October 22, 2004: The ENCODE Consortium publishes a paper in the October 22 issue of Science that sets forth the scientific rationale and strategy behind its quest to produce a comprehensive catalog of all parts of the human genome crucial to biological function.
November 8, 2004: The National Human Genome Research Institute partners with the Department of Health and Human Services and the Office of the Surgeon General to launch a free computer program, My Family Health Portrait, which the public can use to record important family health information that may identify common diseases that run in families.
December 8, 2004: The National Human Genome Research Institute and the International Chicken Genome Sequencing Consortium announces the publication of an analysis comparing the chicken and human genomes. It is the first bird to have its genome sequenced and analyzed.
February 11, 2005: NHGRI establishes Office of Ethics, appointing Barbara Fuller, J.D., as Deputy Ethics Counselor
March 16, 2005: As part of the Human Genome Project, the National Institutes of Health hails the first comprehensive analysis of the sequence of the human X chromosome, saying that this provides sweeping new insights into the evolution of sex chromosomes and the biological differences between males and females.
August 8, 2005: NHGRI announces it has awards grants totaling more than $32 million to advance the development of innovative sequencing technologies intended to reduce the cost of DNA sequencing and expand the use of genomics in biomedical research and health care.
August 29, 2005: In a surprising development, a research team led by NHGRI finds that a class of experimental anti-cancer drugs shows promise in laboratory studies for treating the fatal genetic disorder that causes premature aging.
August 31, 2005: The first comprehensive comparison of the genetic blueprints of humans and chimpanzees shows our closest living relatives share perfect identity with 96 percent of our DNA sequence.
October 5, 2005: The National Institutes of Health announces contracts that will give researchers unprecedented access to two private collections of knockout mice, providing valuable models for the study of human disease and laying the groundwork for a public, genome-wide library of knockout mice.
October 26, 2005: The International HapMap Consortium publishes a comprehensive catalog of human genetic variation, a landmark achievement that is already accelerating the search for genes involved in common diseases, such as asthma, diabetes, cancer and heart disease.
November 15, 2005: As part of the U.S. Surgeon General's Family Health Initiative, an updated version of the computerized tool designed to help families gather their health information is unveiled.
December 13, 2005: The National Cancer Institute and the National Human Genome Research Institute launches a comprehensive effort to accelerate understanding of the molecular basis of cancer through the application of genome analysis technologies, especially large-scale genome sequencing.
March 29, 2006: A multi-institution team of experts, coordinated by geneticists from the National Human Genome Research Institute supports efforts to identify more than 70 bodies still unidentified in the aftermath of Hurricane Katrina.
July 24, 2006: Researchers at the National Institutes of Health Chemical Genomics Center (NCGC) - an NHGRI Affiliated Center - develop a new screening approach that can profile compounds in large chemical libraries more accurately and precisely than standard methods, speeding the production of data that can be used to probe biological activities and identify leads for drug discovery.
August 21, 2006: The National Human Genome Research Institute announces grants totaling $54 million over five years to establish one new Center of Excellence in Genomic Science and continue support for two existing centers.
September 13, 2006: The National Cancer Institute and the National Human Genome Research Institute announce the first three cancers that will be studied in the pilot phase of The Cancer Genome Atlas. The cancers to be studied in the TCGA Pilot Project are lung, brain (glioblastoma) and ovarian.
October 4, 2006: The National Human Genome Research Institute announces the latest round of grant awards totaling more than $13 million to speed the development of innovative sequencing technologies that reduce the cost of DNA sequencing and expand the use of genomics in medical research and health care.
October 16, 2006: The National Cancer Institute and the National Human Genome Research Institute announce another two of the components of The Cancer Genome Atlas Pilot Project, a three-year, $100 million collaboration to test the feasibility of using large-scale genome analysis technologies to identify important genetic changes involved in cancer.
January 14, 2007: The National Human Genome Research Institute celebrated its 10th anniversary as an institute of the National Institutes of Health (NIH), marking a decade that saw genomics emerge as a powerful research tool and looking ahead to an era in which genomics will transform medical care.
April 26, 2007: National Human Genome Research Institute researchers identify new genetic risk factors for type 2 diabetes. In the most comprehensive look at genetic risk factors for type 2 diabetes to date, a U.S.- Finnish team, working in close collaboration with two other groups, has identified at least four new genetic variants associated with increased risk of diabetes and confirmed existence of another six.
May 4, 2007: The National Human Genome Research Institute and the National Cancer Institute, have teamed with Group Health Cooperative in Seattle and Henry Ford Health System in Detroit to launch the Multiplex Initiative, a study to investigate the interest level of healthy, young adults in receiving genetic testing for eight common conditions.
July 2, 2007: As part of The Cancer Genome Atlas pilot project, the National Institutes of Health, National Cancer Institute and NHGRI award eight two-year grants totaling $3.4 million to support the development of innovative technologies for exploring the genomic underpinnings of cancer.
August 1, 2007: Looking ahead to a future in which each person's genome can be sequenced as a routine part of medical research and health care, the National Human Genome Research Institute awards more than $15 million in grants to support development of innovative technologies with the potential to dramatically reduce the cost of DNA sequencing.
August 2, 2007: The National Human Genome Research Institute establishes Genomic Healthcare Branch, headed by William Gregory Feero, M.D., Ph.D., to promote the effective integration of genomic discoveries into healthcare.
August 20, 2007: The National Human Genome Research Institute announces grants of $30 million to establish one, new Center of Excellence in Genomic Science at the Dana Farber-Cancer Institute and continue its support of the center at Stanford University.
August 22, 2007: The National Human Genome Research Institute establishes the Office of Population Genomics headed by Teri Manolio, M.D., Ph.D.
October 9, 2007: The National Human Genome Research Institute announces grants totaling more than $80 million over the next four years to expand the ENCyclopedia Of DNA Elements (ENCODE) project, which in its pilot phase yielded provocative new insights into the organization and function of the human genome.
October 10, 2007: The National Human Genome Research Institute announces the establishment of two new centers to address the most critical ethical, legal and social questions faced by researchers and patients involved in genetic and genomic research.
October 16, 2007: The NIH Intramural Sequencing Center (NISC), an National Human Genome Research Institutes affiliated center, celebrates 10th anniversary with a day-long symposium.
November 4, 2007: An international team of scientists, supported in part by the National Human Genome Research Institute, announces that its systematic effort to map the genomic changes underlying lung cancer has uncovered a critical gene alteration not previously linked to any form of cancer.
December 19, 2007: To better understand the role the astounding assortment of bacteria, fungi and other microbes play in human health and disease, the National Institutes of Health (NIH) announces the official launch of the Human Microbiome Project. The human microbiome is the collective genomes of all microorganisms present in or on the human body.
January 22, 2008: An international research consortium announces the 1000 Genomes Project, an ambitious effort that will involve sequencing the genomes of at least a thousand people from around the world to create the most detailed and medically useful picture to date of human genetic variation.
February 14, 2008: Testing the safety of chemicals ranging from pesticides to household cleaners will benefit from new technologies and a plan for collaboration, according to federal scientists from the National Institutes of Health (NIH) and the U.S. Environmental Protection Agency (EPA), who announced a new toxicity testing agreement.
March 17, 2008: The National Institutes of Health (NIH) announces the establishment of the NIH Intramural Center for Genomics and Health Disparities (NICGHD), a new venue for research about the way populations are impacted by diseases, including obesity, diabetes and hypertension. NICGHD will employ a genomics approach, collecting and analyzing genetic, clinical, lifestyle and socio-economic data to study a range of clinical conditions that have puzzled and troubled public health experts for decades.
April 29, 2008: Research organizations from around the world announce they are launching the International Cancer Genome Consortium (ICGC), a collaboration designed to generate high-quality genomic data on up to 50 types of cancer through efforts projected to take up to a decade.
May 7, 2008: The first analysis of the genome sequence of the duck-billed platypus is published in Nature by an international team of scientists, revealing clues about how genomes were organized during the early evolution of mammals. The research was supported in part by the National Human Genome Research Institute.
May 21, 2008: President Bush signs into law the Genetic Information Nondiscrimination Act (GINA) that will protect Americans against discrimination based on their genetic information when it comes to health insurance and employment. The bill had passed the Senate unanimously and the House by a vote of 414 to 1.
May 28, 2008: Francis S. Collins, M.D., Ph.D., the director of the National Human Genome Research Institute, part of the National Institutes of Health, announces his intention to step down on August 1 to explore writing projects and other professional opportunities.
August 2, 2008: Alan Edward Guttmacher, M.D., becomes Acting Director of NHGRI. He replaces Francis S. Collins, M.D., Ph.D., who stepped down after 15 years at the helm of NHGRI to pursue other professional opportunities.
March 12, 2009: A team that includes researchers from the National Institutes of Health (NIH) has found a new way of detecting functional regions in the human genome. The novel approach involves looking at the three-dimensional shape of the genome's DNA and not just reading the sequence of the four-letter alphabet of its DNA bases.
March 29, 2009: National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a systematic genetic analysis of a group of enzymes implicated in skin cancer and many other types of cancer.
April 20, 2009: The National Human Genome Research Institute announces the release of the first version of a free online toolkit aimed at standardizing measurements of research subjects' physical characteristics and environmental exposures. The toolkit, is the first product of the Consensus Measures for Phenotypes and eXposures (PhenX) initiative.
May 20, 2009: The National Institutes of Health launches a $24 million program to jumpstart a trans-NIH initiative called the Therapeutics for Rare and Neglected Diseases program, or TRND. The NIH Office of Rare Diseases Research (ORDR) will oversee the program, and TRND's laboratory operations will be administered by the National Human Genome Research Institute (NHGRI), which also operates the NIH Chemical Genomics Center (NCGC), a principal collaborator in TRND. Other NIH components will also participate in the initiative.
August 7, 2009: The U.S. Senate confirms that former NHGRI Director Francis S. Collins, M.D., Ph.D., will be the director of the National Institutes of Health (NIH). President Barack Obama announced the nomination of Dr. Collins on July 8th. Dr. Collins, a physician-geneticist who led NHGRI from 1993 to 2008, managed the NIH component of the international Human Genome Project. Statement from HHS Secretary Kathleen Sebelius
November 17, 2009: Francis S. Collins, M.D., Ph.D., director of the National Institutes of Health (NIH), announces the appointment of Eric D. Green, M.D., Ph.D., to be director of the National Human Genome Research Institute (NHGRI). This marks the first time an institute director has risen to lead the entire NIH and subsequently picked his own successor.
February 26, 2010: NHGRI launches the Genetics/Genomics Competency Center (G2C2), an online tool to help educators teach the next generation of nurses and physician assistants about genetics and genomics. The tool is part of NHGRI's effort to address the growing need among health care professionals for knowledge in this area, which is paving the way for more individualized approaches to detect, treat and prevent many diseases.
April 5, 2010: NHGRI names Lawrence C. Brody, Ph.D., as the new chief of its Genome Technology Branch, the largest of seven branches in the NHGRI Division of Intramural Research. The branch is recognized for developing innovative methods and approaches to advance our understanding about the structure and function of genomes.
May 6, 2010: An international research team, including researchers from NHGRI, produce the first whole genome sequence of the 3 billion letters in the Neanderthal genome, and the initial analysis suggests that up to 2 percent of the DNA in the genome of present-day humans outside of Africa originated in Neanderthals or in Neanderthals' ancestors.
June 22, 2010: The National Institutes of Health and the Wellcome Trust, a global charity based in London, announce a partnership called the Human Heredity and Health in Africa project (H3Africa) to support population-based genetic studies in Africa of common, non-communicable disorders such as heart disease and cancer, as well as communicable diseases such as malaria. The studies, to be conducted by African researchers, will utilize genetic, clinical and epidemiologic screening tools that identify hereditary and non-hereditary components that contribute to the risk of illnesses.
August 30, 2010: Daniel L. Kastner, M.D., Ph.D., has been selected to be the Scientific Director of the National Human Genome Research Institute (NHGRI). Dr. Kastner previously served as the Clinical Director and the Director of Translational Research at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
October 7, 2010: The National Institutes of Health announce awards to support the Genotype-Tissue Expression (GTEx) project, an initiative to understand how genetic variation may control gene activity and its relationship to disease. The project will create a resource researchers can use to study inherited susceptibility to illness and will establish a tissue bank for future biological studies.
February 10, 2011: NHGRI's new strategic plan for the future of human genome research was published in the February 10, 2011 issue of Nature magazine. The plan, called Charting a course for genomic medicine from base pairs to bedside, is intended to inspire many to contribute to advancing genomic understanding, especially as other National Institutes of Health (NIH) institutes and centers focus genomic technologies on the diseases they study.
July 5, 2011: P. Paul Liu, M.D., Ph.D. has been named NHGRI's Deputy Scientific Director. Dr. Liu, a tenured senior investigator, joined the National Institutes of Health (NIH) in 1993 as one of NHGRI's first intramural scientists when it was still an NIH center. A world expert in the onset, development and progression of leukemia, Dr. Liu leads the Oncogenesis and Development Section within NHGRI's Genetics and Molecular Biology Branch.
September 7, 2011: NHGRI announces two key leadership appointments: Mark S. Guyer, Ph.D., has been named NHGRI Deputy Director; James C. Mullikin has been selected to be permanent Director of the NIH Intramural Sequencing Center (NISC).
January 11, 2012: NHGRI proposes a regoranization, to expand from the current structure of two divisions - the Division of Extramural Research and the Division of Intramural Research - and the Office of the Director to seven divisions. The new configuration will transform the institute's extramural research program into four new divisions: Division of Genome Sciences, Division of Genomic Medicine, Division of Genomics and Society and Division of Extramural Operations. The other new divisions will be the Division of Policy, Communications and Education and the Division of Management. The Division of Intramural Research will remain essentially unchanged.
May 21, 2012: To celebrate the 10th anniversary of researchers producing the first complete human genome sequence, NHGRI collaborates with the the Smithsonian's National Museum of Natural History (NMNH) in Washington, D.C., to open a high-tech, high-intensity exhibition in 2013. The exhibition also commemorates the 60th anniversary of Drs. James D. Watson** and Francis Crick's discovery of DNA's double helix in 1953 - a revolutionary discovery that laid the foundation for understanding how DNA encodes and copies genetic information to pass on to the next generation.
September 5, 2012: Researchers on the ENCODE (The Encyclopedia of DNA Elements) Project produce a more dynamic picture of the human genome that gives the first holistic view of how the human genome actually does its job. During the new study, researchers linked more than 80 percent of the human genome sequence to a specific biological function and mapped more than 4 million regulatory regions where proteins specifically interact with the DNA. These findings represent a significant advance in understanding the precise and complex controls over the expression of genetic information within a cell. The findings are reported in two papers appearing in the Sept. 5 online issue of Nature.
September 10, 2012: NHGRI announces a major reorganization to accommodate broad changes in its mission at the 66th National Advisory Council for Human Genome Research (NACHGR). The reorganization includes dividing the institute's Extramural Research Program into four new divisions and promoting to division status the office overseeing policy, communications, and education, and the office overseeing administration and management. Approved by the U.S. Department of Health and Human Services on June 26, the reorganization becomes effective October 1. Watch the Announcement
April 14, 2013: This day marks the 10th anniversary of the completion of the Human Genome Project (HGP). Since its completion on April 14, 2003, the National Human Genome Research Institute (NHGRI) and the field of genomics have marched past numerous important milestones on the path to translating genomic findings into medical advances.
June 14, 2013: The Smithsonian Institution in Washington, D.C. opens a high-tech, high-intensity exhibition Genome: Unlocking Life's Code to celebrate the 10th anniversary of researchers producing the first complete human genome sequence - the genetic blueprint of the human body. The exhibition is a collaboration between the Smithsonian's National Museum of Natural History (NMNH) and the National Human Genome Research Institute (NHGRI) of the National Institutes of Health.
September 4, 2013: The National Human Genome Research Institute (NHGRI) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) announce awards for pilot projects to explore the use of genomic sequencing in newborn healthcare, under the Genomic Sequencing and Newborn Screening Disorders research program.
November 14, 2013: NHGRI selects Lawrence C. Brody, Ph.D. to be the first director of the newly established Division of Genomics and Society. Dr. Brody is currently the chief of the Genome Technology Branch within NHGRI's intramural research program, and the chief scientific officer of the trans-NIH Center for Inherited Disease Research.
January 13, 2014: The National Human Genome Research Institute (NHGRI) celebrates the 10th anniversary of the Social and Behavioral Research Branch (SBRB). NHGRI leadership launched SBRB as a branch of the Division of Intramural Research in December 2003 - the year the Human Genome Project was completed.
May 19, 2014: NHGRI Scientific Director Daniel Kastner, M.D., Ph.D., implements the reorganization of NHGRI's 45 intramural investigators and associated research programs into a new arrangement of nine branches. The Division of Intramural Research reorganization was announced at the 71st meeting of the National Advisory Council for Human Genome Research.
July 1, 2014: NHGRI's Mark Guyer retires from federal service. Dr. Guyer played a critical role in the Human Genome Project and countless other genomics programs at what later became the National Center for Human Genome Research (NCHGR) and, ultimately, the National Human Genome Research Institute (NHGRI).
August 26, 2014: After having completed a 14-month engagement at the Smithsonian's National Museum of Natural History (NMNH), the Genome: Unlocking Life's Code exhibition departs for a multi-city traveling exhibition starting on September 1, 2014.
August 27, 2014: The National Institutes of Health issues a final NIH Genomic Data Sharing (GDS) policy to promote data sharing as a way to speed the translation of data into knowledge, products and procedures that improve health while protecting the privacy of research participants. The final policy was posted in the Federal Register Aug. 26, 2014 and published in the NIH Guide for Grants and Contracts Aug. 27, 2014.
November 10, 2014: Robert Wildin, M.D., becomes chief of NHGRI's Genomic Healthcare Branch (GHB), capping off a national search for leadership of the branch, which promotes the integration of genomic discoveries into healthcare and is part of the Division of Policy, Communications, and Education (DPCE).
January 14, 2015: Carla Easter, Ph.D., is named chief of NHGRI's Education and Community Involvement Branch (ECIB) - part of the Division of Policy, Communications and Education (DPCE) - to lead the division's program of genomics education and outreach activities that engage a variety of communities, from pre-college students, to teachers, to members of the general public.
March 27, 2015: Representatives from the Integrative Human Microbiome Project (iHMP), coordinated by NHGRI, present findings at the 5th International Human Microbiome Congress. The Congress, organized by the International Human Microbiome Consortium (IMHC) and the Integrated BioBank of Luxembourg, takes place March 31- April 2 in Luxembourg. The human microbiome consists of trillions of microorganisms living in nearly every part of the human body. While some cause disease, the vast majority are important for health or are harmless.
September 16, 2015: The Undiagnosed Diseases Network (UDN) opens an online patient application portal called the UDN Gateway. Introduction of this application system sets the stage for the network to advance its core mission: to diagnose patients who suffer from conditions that even skilled physicians have been unable to diagnose despite extensive clinical investigation. Watch Video: UDN begins accepting patient applications
October 1, 2015: This day marked the 25th anniversary of the launch of the Human Genome Project. To commemorate this anniversary in a fashion that showcases the rich history of the Human Genome Project and the field of genomics over the last quarter-century, the NHGRI History of Genomics Program hosts a seminar series entitled "A Quarter Century after the Human Genome Project's Launch: Lessons Beyond the Base Pairs." The program will feature Human Genome Project participants, who will be sharing their perspectives about the Project and how it affected their careers.
October 16, 2015: John Ohab, Ph.D., a neuroscientist and science communicator, is named chief of the Communications and Public Liaison Branch (CPLB) - part of the Division of Policy, Communications and Education (DPCE). In this role, he will oversee diverse communications activities about the institute's accomplishments, programs, goals and policies.
December 9, 2015: Cristina Kapustij, M.S., is named chief of the Policy and Program Analysis Branch (PPAB) at the National Human Genome Research Institute (NHGRI). She will oversee policy activities and evaluation as well as program reporting and assessment to support institute priorities.
December 31, 2015: Robert Blakesley, Ph.D., director of the sequencing group at the NIH Intramural Sequencing Center (NISC), retires after a long, distinguished and singularly productive career in DNA sequencing.
January 14, 2016: NIH funds a set of genome sequencing and analysis centers whose research will focus on understanding the genomic bases of common and rare human diseases. NHGRI launches the Centers for Common Disease Genomics (CCDG), to use genome sequencing to explore the genomic contributions to common diseases such as heart disease, diabetes, stroke and autism.
January 14, 2016: NHGRI announces the next phase of a complementary program, the Centers for Mendelian Genomics (CMG), which will continue investigating the genomic underpinnings of rare, typically inherited diseases, such as cystic fibrosis and muscular dystrophy.
April 29, 2016: NHGRI researchers collaborate with physicians and medical geneticists around the world to create the Atlas of Human Malformation Syndromes in Diverse Populations.
May 10, 2016: The Center for Inherited Disease Research (CIDR), an NHGRI-affiliated center established in 1996, celebrates its 20th anniversary as one of the largest genotyping facilities in the world. CIDR's mission is to support the genetics community by providing high quality, cutting-edge genomic service and technologies in order to expand our understanding of disease and catalyze discoveries that translate to patient care.
January 14, 2017: NHGRI celebrates 20 years as an NIH Institute. The milestone highlights the transition from the center known as the National Center for Human Genome Research, to our current status as a full-fledged NIH institute. Those 20 years encompassed a host of research accomplishments, from the completion of The Human Genome Project, to DNA sequencing technology development, to bringing genomic medicine to the clinic.
March 29, 2017: NHGRI releases a collection of oral history videos featuring candid conversations with pioneering genomics researchers and an interactive discussion with the institute's three directors to date. NHGRI plans to release approximately 25 videos over the next year and additional videos in the future.
May 16, 2017: Laura Koehly, Ph.D., is named chief of NHGRI's Social and Behavioral Research Branch (SBRB), which conducts research that will potentially transform healthcare through the integration of genomic medicine into the clinic.
February 12, 2018: NHGRI launches a new round of strategic planning that will establish a 2020 vision for genomics research aimed at accelerating scientific and medical breakthroughs.
March 1, 2018: NIH and INOVA Health System launch The Genomic Ascertainment Cohort (TGAC), a two-year pilot project that will allow them to recall genotyped people and examine the genes and gene variants' influence on their phenotypes, an individual's observable traits, such as height, eye color or blood type.
March 16, 2018: Rep. Louise M. Slaughter (D-N.Y.), lead author of the Genetic Information Nondiscrimination Act of 2008 (GINA), passes away at the age of 88.
April 5, 2018: The Cancer Genome Atlas publishes the PanCancer Atlas, a detailed genomic analysis on a data set of molecular and clinical information from over 10,000 tumors representing 33 types of cancer.
December 23, 2019: NHGRI researchers discover a new autoinflammatory disease called CRIA syndrome.
November 12, 2019: NHGRI appoints Dr. Benjamin Solomon as clinical director.
January 21, 2020: NHGRI appoints Chris Gunter, Ph.D., as a senior advisor to the director for genomics engagement.
February 12, 2020: NHGRI establishes new intramural precision health research program.
June 26, 2020: NHGRI commemorates 20th anniversary of White House event announcing draft human genome sequence.
July 1, 2020: NIH announces the provision of $75 million in funding over five years for the Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network.
July 9, 2020: NHGRI researchers reframe dog-to-human aging comparisons.
July 14, 2020: NHGRI researchers generate the complete human X chromosome sequence.
August 31, 2020: Scientists use genomics to discover ancient dog species that may teach us about human vocalization.
September 30, 2020: The Human Genome Project turns the big 3-0!
October 12, 2020: NHGRI researchers work with patients, families and the scientific community to improve the informed consent process.
January 7, 2021: NHGRI proposes an action agenda for building a diverse genomics workforce.
January 19, 2021: Dr. Neil Hanchard joins NHGRI as a clinical investigator.
February 25, 2021: NHGRI appoints Oleg Shchelochkov as intramural training program director.
March 10, 2021: NIH researchers develop guidelines for reporting polygenic risk scores.
April 5, 2021: NIH scientists develop breath test for methylmalonic acidemia.
May 17, 2021: NHGRI director appoints Vence Bonham as acting deputy director.
October 5, 2021: NIH expands existing gene expression resources to include developmental tissues.
October 7, 2021: Charles Rotimi selected as next scientific director.
October 12, 2021: NHGRI creates Office of Training, Diversity and Health Equity.
December 8, 2021: NHGRI researchers narrow down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.
December 17, 2021: NHGRI selects Valentina Di Francesco as chief data science strategist.
December 17, 2021: NHGRI creates the Office of Genomic Data Science.
December 27, 2021: NIH researchers find thousands of new microorganisms living on human skin.
February 3, 2022: NIH-funded small businesses contributed to the completion of the human genome sequence.
March 31, 2022: Researchers generate the first complete, gapless sequence of a human genome.
May 5, 2022: NHGRI celebrates Bettie Graham’s 50 years of federal service.
August 24, 2022: NHGRI History of Genomics Program celebrates it's 10th anniversary.
September 22, 2022: NHGRI selects Charles P. Venditti as new chief of the Metabolic Medicine Branch.
** James Watson was the first NHGRI Director and appears here as part of our history collection. Despite his scientific achievements, Dr. Watson’s career was also punctuated by a number of offensive and scientifically erroneous comments about his beliefs on race, nationalities, homosexuality, gender and other societal topics. Dr. Watson’s opinions on these topics are unsupported by science and are counter to the mission and values of NHGRI.
Last updated: August 16, 2022