Revisiting the Missing Heritability of Complex Diseases, Ten Years On

Event Details

The National Human Genome Research Institute (NHGRI) sponsored the NHGRI workshop, Revisiting the Missing Heritability of Complex Diseases, Ten Years On, in Silver Spring, Maryland, on May 1–2, 2018. The goals of the workshop were to discuss what was has been learned since 2008, explore the value of identifying sources of missing heritability, and identify research that should be pursued to determine these sources.

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Agenda

Heritability

Executive Summary 
Meeting Summary 

  • Tuesday, May 2, 2018

  • 8:30 a.m Welcome, Introductions
    Peter Visscher
    Teri Manolio
  • 8:45 a.m. Workshop rationale and objectives
    Teri Manolio
    Peter Visscher
  • 9:00 a.m. Impact of missing heritability publication in Nature
    Orli Bahcall

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  • 9:10 a.m. Missing heritability circa 2009
    Teri Manolio

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  • 9:30 a.m. Quantifying the genetic architecture and heritability of complex traits: estimation and prediction
    Peter Visscher

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  • 9:50 a.m. Discussion
    Teri Manolio
  • 10:50 a.m. Quantifying (missing) heritability for common disease from GWAS data
    Naomi Wray

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  • 11:10 a.m. Rare Variants
    David Goldstein

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  • 11:30 a.m. Monogenic contributions to complex traits 
    Judy Cho

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  • 11:50 a.m. Discussion
    Peter Visscher
  • 1:20 p.m. Structural and multi-alleic variation
    Steve McCarroll

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  • 1:40 p.m. Omnigenic architecture of human complex traits
    Jonathan Pritchard

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  • 2:00 p.m. Epigenetic effects and gene expression
    Alexis Battle

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  • 2:20 p.m. Discussion
    Lon Cardon
  • 3:20 p.m. How sex-specific, environment-specific and genetic background-specific effects generate missing heritability
    Trudy Mackay

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  • 3:40 p.m. Gene-environment interaction
    David Hunter

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  • 4:00 p.m. Selection effects on complex trait architecture
    Guy Sella

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  • 4:20 p.m. Discussion
    Erin Ramos
  • 4:50 p.m. Family Studies
    Lynn Jorde

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  • 5:10 p.m. Better phenotyping and use of biomarkers
    David Valle

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  • 5:30 p.m. Discussion
    Greg Gibson

 

  • Wednesday, May 2, 2018

  • 8:30 a.m. Mind the (diversity) gap: Contributions of diverse populations to common disease studies
    Lucia Hindorff

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  • 8:50 a.m. Missing heritability: Contributions from genomic studies in African ancestry populations
    Charles Rotimi

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  • 9:10 a.m. Contribution of diverse populations and expanded catalogues of human variation to our understanding of low frequency and rare variants
    Eimear Kenny

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  • 9:30 a.m. Discussion
    David Hunter
  • 10:30 a.m. Missing epistasis
    Andy Clark

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  • 10:50 a.m. Impact of indirect genetic effects on effect estimages, heritability estimates and missing heritability
    Augie Kong

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  • 11:10 a.m. Discussion
    Lynn Jorde
  • 11:40 a.m. Lessons learned and next steps
    Teri Manolio
    Peter Visscher
    All

    Slides (PDF)
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Last updated: July 2, 2018